Andersen Syndrome

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11 relevant articles (0 outcomes, 0 trials/studies) found for this Disease

Description: A form of inherited long QT syndrome (or LQT7) that is characterized by a triad of potassium-sensitive periodic paralysis, VENTRICULAR ECTOPIC BEATS, and abnormal features such as short stature, low-set ears, and SCOLIOSIS. It results from mutations of KCNJ2 gene which encodes a channel protein (INWARD RECTIFIER POTASSIUM CHANNELS) that regulates resting membrane potential.

Also Known As:

Long QT Syndrome 7; Syndrome, Andersen

Disease Context: Research Results

Cardiovascular Diseases: 18449

Heart Diseases: 12331

Cardiac Arrhythmias: 8618

Long QT Syndrome: 699

Andersen Syndrome: 11

Congenital, Hereditary, and Neonatal Diseases and Abnormalities: 420

Congenital Abnormalities: 9308

Cardiovascular Abnormalities: 167

Congenital Heart Defects: 685

Long QT Syndrome: 699

Andersen Syndrome: 11

Signs and Symptoms Pathological Conditions

Pathologic Processes: 2205

Cardiac Arrhythmias: 8618

Long QT Syndrome: 699

Andersen Syndrome: 11

Related Diseases

1.	Cardiac Arrhythmias (Arrythmia)
2.	Syndrome
3.	Paralysis (Palsy)
4.	Brugada Syndrome
5.	Syncope (Fainting)
7 Diseases and 5 more articles analyzed in the Research Interface, order at left...

Experts

1.	Vanoye, Carlos G: 1 article (05/2007)
2.	George, Alfred L: 1 article (05/2007)
3.	Ballester, Leomar Y: 1 article (05/2007)
4.	Schulze-Bahr, Eric: 1 article (04/2005)
5.	Mozaffar, T: 1 article (06/2003)
6.	Suarez, W A: 1 article (06/2003)
7.	Escolar, D M: 1 article (06/2003)
8.	Szepetowski, P: 1 article (06/2003)
9.	Behr, E: 1 article (06/2003)
10.	Poza, J J: 1 article (06/2003)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Andersen Syndrome:

1.	Inwardly Rectifying Potassium Channels (Inward Rectifier Potassium Channels)IBA 01/01/2004 - "LQT5 by invalidating the Kcne1 K+ channel beta-subunit and the Andersen syndrome by invalidation of the KCNJ2 gene encoding for a cardiac inward rectifier K+ channel" 04/01/2006 - "Mutations in KCNJ2, the gene encoding the human inward rectifier potassium channel Kir2.1, have been identified in Andersen syndrome (or Andersen-Tawil syndrome), an inherited disorder characterized by periodic paralysis, cardiac arrhythmias, and dysmorphic features" Get all the results and reference details, order at left...
2.	Phosphatidylinositol 4,5-Diphosphate (Phosphatidylinositol 4,5 Bisphosphate)IBA 05/01/2007 - "Exaggerated Mg2+ inhibition of Kir2.1 as a consequence of reduced PIP2 sensitivity in Andersen syndrome." 06/10/2003 - "PIP2 binding residues of Kir2.1 are common targets of mutations causing Andersen syndrome." Get all the results and reference details, order at left...
3.	PotassiumIBA 07/16/1999 - "Andersen syndrome is a rare entity and comprises potassium sensitive periodic paralysis, ventricular arrhythmia, and an unusual facial appearance; syncope and sudden death have also been reported" 07/01/2005 - "Loss of function in the slow component of the delayed rectifier potassium current (I(Ks)) channels (KCNQ1, KCNE1), the rapid component of the potassium current (I(Kr)) channels (KCNH2, KCNE2) and the inward rectifier potassium current (I(Kl), Kir2.1) channel (KCNJ2) is linked to the LQTSs (type 1, 2, 5, 6, and 7 (Andersen syndrome)) and the JLNSs (type 1 and 2)" Get all the results and reference details, order at left...
4.	Kir2.1 channelIBA 04/15/2005 - "Short QT syndrome or Andersen syndrome: Yin and Yang of Kir2.1 channel dysfunction." 07/01/2005 - "Loss of function in the slow component of the delayed rectifier potassium current (I(Ks)) channels (KCNQ1, KCNE1), the rapid component of the potassium current (I(Kr)) channels (KCNH2, KCNE2) and the inward rectifier potassium current (I(Kl), Kir2.1) channel (KCNJ2) is linked to the LQTSs (type 1, 2, 5, 6, and 7 (Andersen syndrome)) and the JLNSs (type 1 and 2)" Get all the results and reference details, order at left...
5.	Potassium Channels (Potassium Channel)IBA 09/01/2007 - "OBJECTIVE: Andersen syndrome (AS) is a rare genetic disease caused by mutations of the potassium channel Kir2.1 (KCNJ2)" Get all the results and reference details, order at left...
6.	Ion Channels (Ion Channel)IBA 12/01/2004 - "2. Mutations in cardiac ion channels have been identified as the basis of a wide range of inherited arrhythmia syndromes, including the congenital long QT syndromes, Brugada syndrome, Lenegre syndrome, Andersen's disease and familial atrial fibrillation" Get all the results and reference details, order at left...
7.	Amiodarone (Amiodarona)FDA LinkGeneric 08/13/2002 - "Amiodarone and acetazolamide for the treatment of genetically confirmed severe Andersen syndrome." Get all the results and reference details, order at left...
8.	Acetazolamide (Diamox)FDA LinkGeneric 08/13/2002 - "Amiodarone and acetazolamide for the treatment of genetically confirmed severe Andersen syndrome." Get all the results and reference details, order at left...
9.	Triad FDA Link 05/01/2004 - "Andersen syndrome includes a clinical triad with periodic paralysis, cardiac arrhythmia and dysmorphic features most often mild but relevant" Get all the results and reference details, order at left...
9 Drugs and Important Bio-Agents and 11 more articles analyzed in the Research Interface, order at left...

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