Thiazides

Heterocyclic compounds with SULFUR and NITROGEN in the ring. This term commonly refers to the BENZOTHIADIAZINES that inhibit SODIUM-POTASSIUM-CHLORIDE SYMPORTERS and are used as DIURETICS.

Also Known As:

Networked: 1584 relevant articles (105 outcomes, 171 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Davis, Barry R: 16 articles (01/2021 - 07/2004)
2.	Cushman, William C: 15 articles (01/2022 - 05/2003)
3.	Wright, Jackson T: 11 articles (01/2022 - 05/2003)
4.	Oparil, Suzanne: 10 articles (11/2020 - 05/2003)
5.	Bakris, George L: 10 articles (11/2018 - 12/2002)
6.	Blanchard, Anne: 9 articles (01/2022 - 05/2005)
7.	Calhoun, David A: 9 articles (01/2020 - 09/2011)
8.	ALLHAT Collaborative Research Group: 9 articles (01/2016 - 07/2004)
9.	Fretheim, Atle: 9 articles (07/2007 - 09/2002)
10.	Loffing, Johannes: 8 articles (01/2020 - 09/2004)

Related Diseases

1.	Hypertension (High Blood Pressure) 01/01/2016 - "This study evaluated the ability of printed educational messages to promote the choice of thiazides as the first-line treatment for individuals newly diagnosed with hypertension, a practice supported by good evidence and included in guidelines, and one which could reduce costs to the health care system. " 06/01/2021 - "We determined incident prescribing of thiazides for newly diagnosed hypertension as first-line treatment in Alberta, factors that predicted receiving thiazides vs more costly medications, and how much could be saved if more patients were prescribed thiazides. " 01/01/2016 - "Messages advising the use of thiazides as the first-line treatment of hypertension were mailed to each physician in conjunction with a widely read professional newsletter. " 09/01/1992 - "Thiazides remain, therefore, a safe and effective treatment for patients with hypertension." 10/01/2020 - "The present study examines patient preference data from a randomized clinical trial designed to test the efficacy of a patient activation intervention to promote thiazide prescribing for veteran patients with uncontrolled hypertension. "
2.	Stroke (Strokes) 01/01/2001 - "Beta-blockers are less effective than thiazides as first line treatment and may only reduce stroke events. " 09/27/2017 - "This study aimed to investigate the association between thiazide use and the risk of hip fracture after stroke. " 08/01/2004 - "Subsequent studies using thiazides at 'lower' doses showed prevention of both strokes and coronary events. " 01/01/2020 - "We perform alternative analyses that correct for this misclassification to highlight the impact that misclassification can have on observed associations between an exposure (eg, thiazides) and outcomes (eg, stroke and major adverse cardiovascular events)." 03/04/2019 - "However, the sensitivity analysis revealed that short-term thiazide use (exposure duration < 90 days within 2 years after stroke) significantly increased the risk of vertebral fracture versus non-use (aHR = 1.38, 95% CI = 1.02-1.88, p = 0.039). "
3.	Hypercalciuria 04/01/2015 - "We also demonstrate the efficacy of a treatment with thiazides in terms of hypercalciuria in the majority of patients." 11/01/1984 - "[Contribution of thiazides to the study of idiopathic hypercalciuria]." 04/01/2015 - "Treatment with thiazides effectively reduced hypercalciuria in most cases. " 08/15/2013 - "Role of proximal tubule in the hypocalciuric response to thiazide of patients with idiopathic hypercalciuria." 02/01/2013 - "Under a high-Na+ diet, KO mice exhibited hypercalciuria and increased blood pressure, which were reversed by thiazide treatment. "
4.	Heart Failure 01/01/2020 - "Thiazide use decreased risk of cardiovascular events, particularly heart failure, in nondiabetic high-risk patients receiving intensive BP treatment." 01/01/2020 - "Particularly, heart failure risk was significantly lower in those taking thiazides. " 01/01/2020 - "Thiazide Use and Decreased Risk of Heart Failure in Nondiabetic Patients Receiving Intensive Blood Pressure Treatment." 03/15/1974 - "[Clinical amd metabolic results of a particular combination thiazide-antialdosterone in heart failure]." 01/01/2023 - "Compared to first-line alpha-blockers, first-line thiazides probably result in little to no difference in total mortality (RR 0.98, 95% CI 0.88 to 1.09; 1 trial, 24,316 participants; moderate-certainty), probably reduce total cardiovascular events (12.1% versus 9.0%; RR 0.74, 95% CI 0.69 to 0.80; 2 trials, 24,396 participants; ARR 3.1%; moderate-certainty) and stroke (2.7% versus 2.3%; RR 0.86, 95% CI 0.73 to 1.01; 2 trials, 24,396 participants; ARR 0.4%; moderate-certainty), may result in little to no difference in CHD (RR 0.98, 95% CI 0.86 to 1.11; 2 trials, 24,396 participants; low-certainty), probably reduce heart failure (5.4% versus 2.8%; RR 0.51, 95% CI 0.45 to 0.58; 1 trial, 24,316 participants; ARR 2.6%; moderate-certainty), and may reduce withdrawals due to adverse effects (1.3% versus 0.9%; RR 0.70, 95% CI 0.54 to 0.89; 3 trials, 24,772 participants; ARR 0.4%; low-certainty). "
5.	Renal Insufficiency (Renal Failure) 11/01/2012 - "Studies evaluating the efficacy of thiazides in renal insufficiency or dialysis were limited to those that included blood pressure measurements. " 02/01/2005 - "Thiazides are not believed to be efficient in advanced renal failure, but this is debated. " 04/02/2004 - "[Is it useful to treat a severe renal insufficiency with thiazides?]." 06/01/1993 - "A 79-year-old man developed a renal insufficiency while on thiazide. " 02/02/1980 - "Thiazides for hypertension with renal failure."

Related Drugs and Biologics

1.	Diuretics
2.	Calcium
3.	Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)
4.	Chlorthalidone (Chlortalidone)
5.	Antihypertensive Agents (Antihypertensives)
6.	Calcium Channel Blockers (Blockers, Calcium Channel)
7.	Sodium Potassium Chloride Symporter Inhibitors (Loop Diuretics)
8.	Sodium Chloride Symporter Inhibitors (Diuretics, Thiazide)
9.	Thiazides
10.	Angiotensin Receptor Antagonists

Related Therapies and Procedures

1.	Therapeutics
2.	Drug Therapy (Chemotherapy)
3.	Diet Therapy (Therapy, Diet)
4.	Lithotripsy (Extracorporeal Shockwave Lithotripsy)
5.	Hormone Replacement Therapy (Therapy, Hormone Replacement)