Graves Ophthalmopathy

791  relevant articles (62 outcomes, 88 trials/studies) found for this Disease

Congestive Ophthalmopathy; Dysthyroid Ophthalmopathy; Edematous Ophthalmopathy; Myopathic Ophthalmopathy; Ophthalmopathies, Thyroid-Associated; Thyroid-Associated Ophthalmopathies; Congestive Ophthalmopathies; Dysthyroid Ophthalmopathies; Edematous Ophthalmopathies; Infiltrative Ophthalmopathies; Infiltrative Ophthalmopathy; Myopathic Ophthalmopathies; Ophthalmopathies, Congestive; Ophthalmopathies, Dysthyroid; Ophthalmopathies, Edematous; Ophthalmopathies, Infiltrative; Ophthalmopathies, Myopathic; Ophthalmopathies, Thyroid Associated; Ophthalmopathy, Congestive; Ophthalmopathy, Dysthyroid; Ophthalmopathy, Edematous; Ophthalmopathy, Graves; Ophthalmopathy, Myopathic; Ophthalmopathy, Thyroid Associated; Thyroid Associated Ophthalmopathies; Thyroid Associated Ophthalmopathy; Ophthalmopathy, Infiltrative; Ophthalmopathy, Thyroid-Associated; Thyroid-Associated Ophthalmopathy

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Exophthalmos (Proptosis)
2.	Optic Nerve Diseases (Optic Neuropathy)
3.	Hyperthyroidism
4.	Hypothyroidism
5.	Systemic Lupus Erythematosus (Libman-Sacks Disease)
82 Diseases and 262 more articles analyzed in the Full Patient-Physician Summary Report, order at left...

Experts

1.	Smith, Terry J: 6 articles (09/2008 - 03/2002)
2.	Bahn, Rebecca S: 6 articles (10/2007 - 03/2002)
3.	Myśliwiec, Janusz: 5 articles (03/2007 - 08/2002)
4.	Luo, Qing-li: 5 articles (01/2007 - 12/2003)
5.	Marcocci, C: 5 articles (05/2005 - 05/2000)
6.	Pinchera, A: 5 articles (05/2005 - 05/2000)
7.	Hiromatsu, Yuji: 4 articles (12/2006 - 03/2002)
8.	Sowiński, Jerzy: 4 articles (04/2006 - 01/2004)
9.	Prummel, M F: 4 articles (09/2005 - 03/2000)
10.	Wiersinga, W M: 4 articles (09/2005 - 03/2000)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Graves Ophthalmopathy:

1.	Adrenal Cortex Hormones (Corticosteroids)IBA 05/15/2004 - "These data demonstrate that corticosteroids are effective in reduction of peripheral oxidative stress present in infiltrative Graves' ophthalmopathy, but this effect tends to be transient." 11/01/2003 - "CONCLUSIONS: Corticosteroids seem to be an effective treatment for Graves' ophthalmopathy compared to other treatments currently available" 11/01/2003 - "BACKGROUND: The purpose of the present study was to evaluate the efficacy of corticosteroids in the treatment of Graves' ophthalmopathy in comparison to other treatment modalities" 05/15/2004 - "This study was undertaken to investigate corticosteroids treatment influence on blood extracellular indices of ROS metabolism in Graves' ophthalmopathy patients" 02/15/2004 - "METHODS: Randomized, controlled studies comparing oral versus intravenous corticosteroids in the therapy of Graves' ophthalmopathy were selected" Get all the results and reference details, order at left...
2.	MethylprednisoloneFDA LinkGeneric 06/01/2006 - "This infiltrative ophthalmopathy showed marked improvement after additional treatment with high-dose methylprednisolone and orbital radiation, in parallel with a decrease in TBII" 12/01/1987 - "This preliminary study was undertaken to investigate the efficacy of high-dose iv methylprednisolone pulse therapy in 5 patients with Graves' ophthalmopathy" 02/01/1993 - "To investigate the efficacy of intravenous methylprednisolone pulse therapy on Graves' ophthalmopathy (GO), fifteen patients with severe GO were treated with large dose intravenous methylprednisolone (at a daily dosage of 1 g for 3 successive days)" 01/01/1994 - "These results suggest that high-dose methylprednisolone followed by orbital radiotherapy is a good therapeutic design for Graves' ophthalmopathy and justify a prospective randomized trial." 01/01/2008 - "Application of digital infrared thermal imaging in determining inflammatory state and follow-up effect of methylprednisolone pulse therapy in patients with Graves' ophthalmopathy." Get all the results and reference details, order at left...
3.	Troleandomycin (TAO)FDA Link 01/01/1992 - "To investigate the efficacy of magnetic resonance imaging (MRI) in the assessment of thyroid-associated ophthalmopathy (TAO), 51 patients with TAO were evaluated by ophthalmologic examinations and MRI at 0.5 T" 06/01/2006 - "PURPOSE: Recent studies concerning the association between extraocular muscle (EOM) enlargement in thyroid-associated ophthalmopathy (TAO) and immunological and clinical activity have not been conclusive, probably due to a lack of uniform imaging methods (ultrasonography, computer tomography [CT] or magnetic resonance imaging [MRI]) and difficulties in the determination of EOM volume" 08/01/2004 - "OBJECTIVE: To study the clinical values of measurement of blood flow velocity in central retinal artery in thyroid-associated ophthalmopathy (TAO)" 03/01/1995 - "The exact pathogenic mechanism of thyroid-associated ophthalmopathy (TAO) remains unclear, and extensive studies on this disorder have resulted in often conflicting data" 01/01/1992 - "Glycosaminoglycan (GAG) accumulation in the retrobulbar space of patients with thyroid-associated ophthalmopathy (TAO) has been documented in a number of immunohistochemical studies" Get all the results and reference details, order at left...
4.	Octreotide (Sandostatin)FDA LinkGeneric 08/01/1999 - "We conclude that octreotide seems to be a safe and effective drug in Graves' ophthalmopathy, especially in improving soft tissue involvement, and can be used in patients who are unresponsive to glucocorticoid treatment or who cannot use these drugs for some reason." 12/01/2006 - "Randomized, double-blind, placebo-controlled trial of long-acting release octreotide for treatment of Graves' ophthalmopathy." 12/01/2004 - "Double-blind, placebo-controlled trial of octreotide long-acting repeatable (LAR) in thyroid-associated ophthalmopathy." 08/01/1999 - "In this study, nine patients with Graves' ophthalmopathy with positive clinical activity score (CAS), who were either unresponsive or not suitable for glucocorticoid treatment, were given 100 microg of octreotide three times daily, subcutaneously, for three months" 09/01/2005 - "Analysis of peripheral blood T-cell subsets in active thyroid-associated ophthalmopathy: absence of effect of octreotide-LAR on T-cell subsets in patients with thyroid-associated ophthalmopathy." Get all the results and reference details, order at left...
5.	SteroidsIBA 12/01/1996 - "To evaluate the efficacy of high-dose intravenous steroid pulse followed by oral steroids in the treatment of thyroid-associated ophthalmopathy, we performed clinical assessment and measurement of retroorbital muscle enlargement in 27 patients before and after the therapy, and followed them up longitudinally" 10/01/2005 - "Combined orbital irradiation and systemic steroids compared with systemic steroids alone in the management of moderate-to-severe Graves' ophthalmopathy: a preliminary study." 10/01/2005 - "CONCLUSION: A combination of orbital irradiation and systemic steroids is well tolerated and more effective than steroids alone in the treatment of active moderate-to-severe Graves' ophthalmopathy" 10/01/2005 - "PATIENTS: Sixteen patients with active moderate-to-severe Graves' ophthalmopathy who were randomly assigned to steroid therapy (ST group) or combination therapy of orbital irradiation and systemic steroids (SRT group) between June 2000 and June 2003" 10/01/2005 - "OBJECTIVE: To assess the efficacy and safety of combined orbital irradiation and systemic steroids in the management of moderate-to-severe Graves' ophthalmopathy" Get all the results and reference details, order at left...
6.	GlucocorticoidsIBA 11/01/1991 - "Orbital radiotherapy combined with high dose systemic glucocorticoids for Graves' ophthalmopathy is more effective than radiotherapy alone: results of a prospective randomized study." 11/01/1991 - "We have carried out a prospective study to investigate whether orbital radiotherapy combined with high dose systemic glucocorticoids is more effective than orbital radiotherapy alone for Graves' ophthalmopathy" 08/01/2001 - "Comparison of the effectiveness and tolerability of intravenous or oral glucocorticoids associated with orbital radiotherapy in the management of severe Graves' ophthalmopathy: results of a prospective, single-blind, randomized study." 10/15/1998 - "OBJECTIVE: To observe smoking behavior in a randomized study of the effect of radioiodine therapy on ophthalmopathy and in a case series of patients with Graves ophthalmopathy receiving orbital radiation therapy and glucocorticoids" 12/01/2006 - "Glucocorticoids are usually given for management of Graves' ophthalmopathy (GO) for their anti-inflammatory and immunosuppressive effects" Get all the results and reference details, order at left...
7.	Intravenous Immunoglobulins (IVIG)FDA Link 08/01/1997 - "These data suggest that IVIG is safe and effective in reducing the eye changes in patients with Graves' ophthalmopathy." 01/01/1992 - "These preliminary results suggest that IVIG is safe and effective in the treatment of Graves' ophthalmopathy." 05/01/2001 - "Intravenous immunoglobulins treatment of patients with Graves' ophthalmopathy]" 09/01/1992 - "Three patients affected with Graves' ophthalmopathy and pretibial myxoedema have been treated with high dose intravenous immunoglobulins" 01/01/1994 - "Seven patients affected by Graves' ophthalmopathy and pretibial myxedema (four patients with nodular form, two with diffuse, and one with elephanthiasic form) have been treated with high-dose intravenous immunoglobulins" Get all the results and reference details, order at left...
8.	Prednisone (Sone)FDA LinkGeneric 10/16/1993 - "Randomized double-blind trial of prednisone versus radiotherapy in Graves' ophthalmopathy." 01/01/1993 - "During the last four years (1990-1994) the patients with Graves' ophthalmopathy from the study group were treated with Prednisone after radioiodine therapy; this corticotherapy contributes to the lower percentage (1.5%) of worsening Graves' ophthalmopathy after radioiodine therapy." 09/01/2005 - "Treatment of thyroid-associated ophthalmopathy: comparative study between prednisone and COP therapy]" 02/01/2001 - "BACKGROUND: Two-thirds of patients with Graves' ophthalmopathy (GO) respond to immunosuppressive treatment (prednisone or orbital irradiation), but one-third do not respond" 11/01/2000 - "During subsequent treatment with additional radioiodine therapy Graves' ophthalmopathy developed which was severe and required treatment with prednisone and orbital radiotherapy" Get all the results and reference details, order at left...
9.	Cyclosporine (Ciclosporin)FDA LinkGeneric 07/01/1991 - "Cyclosporine in Graves' ophthalmopathy." 06/01/1988 - "Immunosuppressive treatment of Graves' ophthalmopathy with cyclosporine A." 01/01/1987 - "Treatment of malignant Graves' ophthalmopathy with cyclosporin-A--a case report." 01/01/1986 - "We conclude that cyclosporin A has no convincing effect in the treatment of Graves' ophthalmopathy, but rather exerts serious renal effects." 01/01/1986 - "Six patients with Graves' ophthalmopathy (2 with acute and 4 with chronic alterations) were treated with cyclosporin A (10 mg/kg/day) for 5 weeks" Get all the results and reference details, order at left...
10.	CobaltIBA 01/01/1991 - "Early results of combined use of glucocorticoid administration and irradiation with radioactive cobalt for treatment of oedematous-infiltrative ophthalmopathy associated with Graves' disease have been analyzed in a group of 33 patients including 28 women and 5 men of age between 25 and 66 years (mean age 47.3 years)" 01/01/1991 - "Very good and good results obtained in 97% of patients indicate that the administration of glucocorticoids combined with the irradiation of retrobulbar tissues with radioactive cobalt can now be regarded as the most effective method of treatment of the progressive oedematous-infiltrative ophthalmopathy." 07/01/1987 - "Combined therapy with systemic corticosteroids and orbital cobalt radiotherapy has been shown to be an effective treatment of severe Graves' ophthalmopathy" 06/01/1983 - "In conclusion, the present study indicates that both orbital cobalt irradiation combined with systemic methylprednisolone treatment and systemic methylprednisolone therapy alone are valuable methods of treatment for Graves' ophthalmopathy, but the combined therapy proved to be more effective." 08/01/2003 - "We investigated the long-term side-effects of orbital radiotherapy (OR) in 204 patients with Graves' ophthalmopathy (GO), irradiated from 1972-1996 [44 by cobalt unit (CU) and 160 by linear accelerator (LA), mostly combined with glucocorticoids], with a 5- to 25-yr follow-up (median, 11 yr)" Get all the results and reference details, order at left...
242 Drugs and Important Bio-Agents and 679 more articles analyzed in the Full Patient-Physician Summary Report, order at left...

Therapies and Procedures

1.	Decompression 07/01/2003 - "The authors conclude that three-wall orbital decompression can be effective in improving the vision of patients with Graves ophthalmopathy whose vision failed to improve with conservative therapy." 05/06/2002 - "DISCUSSION: Transcranial two-wall orbital decompression is effective in patients with thyroid-associated ophthalmopathy and complications seem rare" 02/01/1993 - "Transantral decompression of the orbit offers a safe and effective therapeutic modality for vision-threatening Graves' ophthalmopathy." 11/01/2004 - "CONCLUSIONS: Endoscopic orbital decompression with removal of the medial orbital wall and medial part of the floor in the five reported eyes was an effective and safe procedure for treatment of severe Graves' ophthalmopathy" 11/01/2005 - "CONCLUSION: This data supports the safety, efficiency, and efficacy of endoscopic orbital decompression for unilateral and bilateral Graves' ophthalmopathy" Get all the results and reference details, order at left...
2.	Plasma Exchange 01/01/1988 - "In conclusion, intensive plasma exchange provided prompt and effective improvement in patients with severe progressive Graves' ophthalmopathy" 01/01/1986 - "In conclusion, intensive plasma exchange provided prompt and effective improvement in patients with severe progressive Graves' ophthalmopathy" 01/01/1990 - "Plasma exchange in Graves' ophthalmopathy." 01/01/1989 - "Plasma exchange therapy for severe Graves' ophthalmopathy." 01/01/1988 - "The data suggest that plasma exchange may represent the best primary treatment for severe progressive Graves' ophthalmopathy." Get all the results and reference details, order at left...
3.	Thyroidectomy 03/01/2002 - "In conclusion, total thyroidectomy can be performed as safely as subtotal thyroidectomy and is more effective for Graves' ophthalmopathy than subtotal thyroidectomy" 04/01/2007 - "A 46-year-old female patient with previously recognized Graves' ophthalmopathy, underwent total thyroidectomy" 07/01/2003 - "Effects of thyroidectomy alone or followed by radioiodine ablation of thyroid remnants on the outcome of graves' ophthalmopathy." 03/01/2002 - "Surgical influences on Graves' ophthalmopathy were compared between total and subtotal thyroidectomy in each of 50 gender- and age-matched cases from the same period" 03/01/2002 - "Total thyroidectomy was performed in 54 cases of Graves' ophthalmopathy from 1971 to August 2000" Get all the results and reference details, order at left...
4.	Aftercare (After-Treatment) 11/01/2007 - "Intraocular pressure after treatment for thyroid-associated ophthalmopathy]" 09/01/2006 - "Pulsatile ocular blood flow change after treatment with systemic steroid in patients with Graves' ophthalmopathy." 05/01/2000 - "In seven patients, Graves ophthalmopathy progressed after treatment, but this progression was not associated with the dose used" 11/01/1998 - "Clinical activity of Graves' ophthalmopathy was evaluated before and after treatment by calculating the ophthalmopathy index (OI)" 06/01/2008 - "Appearances of and increases in Graves' ophthalmopathy (GO) have been reported after treatment of patients with hyperthyroidism with radioiodine" Get all the results and reference details, order at left...
5.	Surgical Decompression 12/01/1996 - "In two cases without DON, pressures were 11 and 9 mm Hg. Forces exerted by spatula manipulation usually resulted in a RBP level of more than 70 mm Hg. CONCLUSIONS: This study shows that RBPs are markedly elevated in Graves' ophthalmopathy and that surgical decompression can result in a significant reduction in the intraorbital pressure" 04/01/2005 - "We briefly recall the history of surgical decompression techniques and present our experience with Graves' ophthalmopathy patients." 12/01/1996 - "In order to investigate the pressure levels involved, intraorbital pressure, or retrobulbar pressure (RBP) was measured continuously in orbits of patients with Graves' ophthalmopathy during surgical decompression" 01/01/1994 - "Characteristic of a Graves' ophthalmopathy, the vision was responsive to either corticosteroid or surgical decompression, or to a combination thereof" 09/01/2006 - "Author's response: medical or surgical decompression of optic neuropathy in Graves' ophthalmopathy: the choice remains unclear." Get all the results and reference details, order at left...
26 Therapies and Procedures and 148 more articles analyzed in the Full Patient-Physician Summary Report, order at left...