|2.||Chromosome Aberrations (Chromosome Abnormalities)
|3.||Lung Neoplasms (Lung Cancer)
|4.||Xeroderma Pigmentosum (Kaposi's Disease)
|5.||Ataxia Telangiectasia (Louis Bar Syndrome)
|1.||van Steeg, Harry: 9 articles (09/2011 - 03/2003)|
|2.||Sarasin, Alain: 7 articles (01/2010 - 10/2002)|
|3.||Takeda, Shunichi: 6 articles (02/2016 - 05/2004)|
|4.||Menck, Carlos Frederico Martins: 5 articles (08/2013 - 10/2002)|
|5.||Luijten, Mirjam: 4 articles (09/2011 - 04/2006)|
|6.||Beems, Rudolf B: 4 articles (10/2009 - 03/2003)|
|7.||de Vries, Annemieke: 4 articles (10/2009 - 03/2003)|
|8.||Wells, Peter G: 3 articles (01/2015 - 01/2011)|
|9.||Niedernhofer, Laura J: 3 articles (03/2014 - 08/2012)|
|10.||Kraemer, Kenneth H: 3 articles (09/2013 - 02/2007)|
|1.||DNA (Deoxyribonucleic Acid)IBA
01/01/1991 - "In this study, a sensitive host cell reactivation (HCR) technique was used to examine the repair capacity for DNA damaged by sunlamp exposure in fibroblast strains derived from 5 normal individuals and 8 patients representing three different diseases associated with DNA repair deficiencies. "
08/01/2014 - "Use of DNA repair-deficient cells or repair pathway inhibitors further increase levels of acetylated WRN, indicating that induced DNA lesions and their persistence are at least partly responsible for increased acetylation. "
09/01/2013 - "The host cell reactivation (HCR) assay is a functional assay that is based on the independent transfection of cells with either damaged or undamaged plasmid DNA and allows the identification of the genes responsible for DNA repair-deficient syndromes. "
06/01/2013 - "We investigated the effect of the TR HP on recombination by comparing specific DNA substrates transfected into wild-type and DNA-repair-deficient cells. "
08/01/2012 - "We found that cPu accumulate spontaneously in the nuclear DNA of wild-type mice with age and to a greater extent in DNA repair-deficient progeroid mice, with a similar tissue-specific pattern (liver > kidney > brain). "
03/01/2014 - "Degeneration was not exacerbated in congenic DNA repair-deficient mice, indicating that DNA damage per se does not have a significant causal role in driving smoke-induced spine degeneration."
03/01/2014 - "Two-month-old wild-type (C57BL/6) and DNA repair-deficient Ercc1(-/Δ) mice were exposed to tobacco smoke by direct inhalation (4 cigarettes/day, 5 days/week for 7 weeks) to model first-hand smoking in humans. "
03/01/2014 - "To compare the effect of chronic tobacco smoke inhalation on intervertebral disc and vertebral bone in normal and DNA repair-deficient mice to determine the contribution of DNA damage to degenerative changes. "
01/01/2014 - "DNA-repair deficiencies have been considered of interest in lung cancer prevention, given the persistence of damage produced by cigarette smoke in this setting, as well as in treatment, given potential increased efficacy of DNA-damaging drugs. "
10/01/2003 - "These results suggest that individuals who smoke and have the XPD codon 312 Asp/Asp genotype may be at a greater risk of p53 mutations, especially if combined with other polymorphisms that may result in deficient DNA repair."
01/01/2008 - "DNA repair deficiency and acetaldehyde-induced chromosomal alterations in CHO cells."
01/01/2008 - "Induction of chromosomal aberrations (CAs) and sister chromatid exchanges (SCEs) by acetaldehyde (AA) was evaluated in parental and different DNA repair-deficient Chinese hamster ovary (CHO) cell lines to elucidate the mechanisms involved in the protection against AA-induced chromosome damage. "
01/01/1996 - "Evidence is accumulating from studies with DNA repair deficient strains that damage produced by endogenous mutagens may be an important source of such mutations. "
12/15/2008 - "The sensitivity of DNA-repair-deficient Rad54/Rad54B mice for clastogens was studied and compared to that of wild-type mice. "
12/15/2008 - "DNA-repair-deficient Rad54/Rad54B mice are more sensitive to clastogens than wild-type mice."
01/01/1983 - "The use of DNA-repair-deficient mutants of Chinese hamster ovary cells in studying mutagenesis mechanisms and testing for environmental mutagens."
01/01/1977 - "Development and applications of Bacillus subtilis test systems for mutagens, involving DNA-repair deficiency and suppressible auxotrophic mutations."
|6.||A-Form DNA (A-DNA)IBA
12/01/2013 - "Studies in DNA repair-deficient mice show that MAM perturbs brain development through a DNA damage-mediated mechanism. "
10/15/1992 - "Sequence data were obtained from 71 independently arising mutants recovered from DNA repair deficient xeroderma pigmentosum (XP) cells [XP12BE(SV40)] and 60 mutants recovered from a DNA repair proficient cell line (GM0637). "
10/01/1996 - "However, crc mutants do not have a DNA repair phenotype, nor can the crc gene complement Escherichia coli DNA repair-deficient strains. "
06/01/1985 - "From a comparison with alkylation-induced mutational spectra, we note a number of peculiarities of HMPA mutagenesis: there is no storage effect on HMPA-induced translocations; the ratio of F2-lethals: F3-lethals varies from 6:1 to 9:1, indicating a low capacity of HMPA for delayed mutations; the use of the DNA-repair-deficient mei-9L1 females instead of an excision-proficient control strain has no influence on the recovery of mutations (recessive lethals) induced in males; the high frequencies of chromosome loss (CL) induced by HMPA, which are mostly due to ring-X loss, leads us to speculate that one (or more) of its metabolites acts as a DNA-crosslinking agent. "
07/01/1990 - "We have isolated a DNA endonuclease, pI 7.6, from the chromatin of normal human lymphoblastoid cells which recognizes damage produced by UVC light, and have introduced this endonuclease into UVC-irradiated XPA cells in culture to determine whether it can restore their markedly deficient DNA repair-related unscheduled DNA synthesis (UDS). "
|7.||Cisplatin (Platino)FDA LinkGeneric
01/01/1989 - "This study demonstrates that whilst some DNA-repair deficiencies can be detected using host cell reactivation of cisplatin (CDDP)-treated adenovirus (Ad5), not all repair deficiencies affected replication of CDDP-treated Ad5 in human cells. "
03/18/2008 - "Although the Mlh1(G67R) mutation resulted in DNA repair deficiency in homozygous mutant mice, it did not affect the MMR-mediated cellular response to DNA damage, including the apoptotic response of epithelial cells in the intestinal mucosa to cisplatin, which was defective in Mlh1(-/-) mice but remained normal in Mlh1(G67R/G67R) mice. "
05/01/1999 - "Mismatch DNA repair deficiency is associated with resistance to certain major groove alkylating agents including methylating agents and cisplatin. "
07/01/1980 - "The antitumor agent cis-platinum(II)diamminodichloride (PDD) caused wild-type and recA+ deoxyribonucleic acid (DNA) repair-deficient mutant cells of Escherichia coli K-12 to grow as long, multinucleated filaments. "
10/01/2014 - "A subset of TNBC, however, has intrinsic genomic instability caused by deficient DNA repair that could lead to the success of platinum agents (cisplatin or carboplatin) in treatment. "
|8.||Interleukin-12 (IL 12)IBA
01/17/2005 - "IL-12 did not prevent the development of UV-induced regulatory T cells in DNA repair-deficient mice. "
04/01/2006 - "IL-12 knockout (KO) mice on C3H/HeN background and DNA repair-deficient cells from xeroderma pigmentosum complementation group A (XPA) patients were used in this study. "
01/17/2005 - "IL-12 prevented both UV-induced suppression of the induction of contact hypersensitivity and the depletion of Langerhans cells, the primary APC of the skin, in wild-type but not in DNA repair-deficient mice. "
03/01/2006 - "These effects were not observed in DNA repair-deficient (XpaKO) mice, indicating that IL-18 like IL-12 reduces DNA damage via DNA repair. "
|9.||Plasminogen Activators (Plasminogen Activator)IBA
10/01/1981 - "Normal and DNA repair-deficient human fibroblasts have been used to study induction of plasminogen activator (PA) by DNA damage. "
12/01/1988 - "Plasminogen activator (PA) synthesis in alkylation DNA repair deficient (mer-) and proficient (mer+) human tumour cell strains exposed to an alkylating agent, N-methyl-N'-nitro-N-nitrosoguanidine (MNNG), has been studied. "
05/01/1986 - "Alkylating agents, mechlorethamine and N-methyl-N'-nitro-N-nitrosoguanidine, induce the production of plasminogen activator in U-87MG cells, an alkylation DNA repair deficient (Mer-) human glioblastoma strain. "
|10.||Lamin Type A (Lamin A)IBA
06/01/2013 - "The follow-up of the complete clinical course in the patient combined with functional studies showed for the first time that a progressive loss of lamin A rather than abnormal accumulation of prelamin A species could be a pathophysiological mechanism in progeroid laminopathies, which leads to DNA repair deficiency accompanied by advancing tissue degeneration. "
01/01/1995 - "After treatment with EMS, we noted a deficient DNA repair capacity in quiescent lymphocytes in comparison with replicating cells. "
11/15/2003 - "Some of these DNA repair deficiencies are manifested at the level of the mitotic chromosome as increased breakage, particularly after treatment with specific mutagens. "
02/01/1999 - "Treatment of DNA-repair-deficient xeroderma pigmentosum patients or skin cancer patients with T4N5 liposome lotion containing such DNA repair liposomes increases the removal of DNA damage in the first few hours after treatment. "
01/01/1983 - "The gene locus assignments were taken from a recent review (McKusick 1982); the chromosomal distances were those estimated by Hager et al. (1982) from the frequencies of reunion figures between specific chromosomes as observed in chromosome instability syndromes (Fanconi anemia, Bloom syndrome) and after treatment with Trenimon. "
02/01/1994 - "The popular idea that DNA polymerase beta participates in DNA repair was not supported by the observation that a pair of a normal and a pol beta strain, and the other pair of a mei-9 mei-41 (DNA-repair deficient double mutations) strain and a pol beta mei-9 mei-41 strain, showed no difference in survival within each pair after treatment with ultraviolet light, methylmethane sulfonate and mitomycin C. "
|2.||Drug Therapy (Chemotherapy)
01/01/2012 - "Interestingly, DNA repair-deficient cancer cells (e.g., those with BRCA1/2 mutations) have been shown to exhibit increased sensitivity to chemotherapy. "
01/01/2011 - "Inhibiting one of these pathways in the context of an already DNA repair-deficient genetic background, will be more toxic to cancer cells than to normal cells, a concept recently exploited in cancer chemotherapy by the synthetic lethality approach. "
01/01/2015 - "Therefore, reliable biomarkers to identify DNA repair-deficient cancers prior to treatment may be useful for directing patients to platinum chemotherapy and possibly PARP inhibitors. "
06/01/2012 - "Enhanced radiosensitivity is an uncommon phenomenon attributable to deficient DNA repair after radiotherapy which can be assessed with the γ-H2AX assay. "
07/01/1982 - "We hypothesized that the sister chromatid exchanges assay in acute leukemia long-term survivors may detect: (a) long-term effects of combined chemo- and radiotherapy; and possibly (b) those individuals with inherently deficient DNA repair. "