|1.||Kobayashi, N: 2 articles (12/2011 - 02/2011)|
|2.||Watanabe, K: 2 articles (12/2011 - 02/2011)|
|3.||Herr, Anna-Maria: 1 article (07/2015)|
|4.||Hemmerlein, Bernhard: 1 article (07/2015)|
|5.||Burfeind, Peter: 1 article (07/2015)|
|6.||Büchner, Anja: 1 article (07/2015)|
|7.||Günthert, Andreas R: 1 article (07/2015)|
|8.||Kaulfuss, Silke: 1 article (07/2015)|
|9.||Kitabayashi, Issay: 1 article (03/2014)|
|10.||Aikawa, Yukiko: 1 article (03/2014)|
|1.||Breast Neoplasms (Breast Cancer)
01/01/2011 - "To investigate the respective roles of cytoplasmic and nuclear LIMK1 in breast cancer progression, we targeted GFP-LIMK1 to cytoplasmic and nuclear subcellular compartments by fusing nuclear export signals (NESs) or nuclear localization sequences (NLS), respectively, to the amino-terminus of GFP-LIMK1. "
05/01/2011 - "In order to characterize the relationship between the growth-arresting activity of Cx26 and its cytoplasmic localizations after expression, we linked a nuclear export signal (NES) sequence to Cx26 cDNA before transfecting into a rat breast cancer cell line. "
03/01/2009 - "Recently, amino-terminal splicing isoforms of PRMT1 were shown to differ significantly in intracellular localization, the most interesting being splice variant 2 that carries a nuclear export signal in its amino terminus, and is expressed in increased levels in breast cancer cells. "
02/01/2012 - "To study the possible role of Achn in breast cancer, we engineered human MDA-MB-231 cells to stably express enhanced green fluorescent protein-tagged wild-type Achn (AchnWT), as well as Achn lacking either its nuclear localization signal (AchnNLS) or its nuclear export signal (AchnNES). "
|2.||Hepatocellular Carcinoma (Hepatoma)
12/01/2003 - "In the present study we mutated Leu375 to alanine in the nuclear export signal of Foxo1 (mouse FOXO1), so that it would remain in the nucleus of H4IIE rat hepatoma cells after insulin treatment, and determined whether insulin could still inhibit transcription stimulated by the Foxo1 mutant. "
10/01/2013 - "A cancer-associated BRCA2 mutation reveals masked nuclear export signals controlling localization."
02/01/2013 - "Driven by its nuclear export signal (NES), Survivin shuttles between the nucleus and the cytoplasm, and is detectable in both cellular compartments in tumor biopsies. "
08/15/2005 - "Apoptin nuclear accumulation is modulated by a CRM1-recognized nuclear export signal that is active in normal but not in tumor cells."
09/15/2002 - "Nucleocytoplasmic transfer of the NF2 tumor suppressor protein merlin is regulated by exon 2 and a CRM1-dependent nuclear export signal in exon 15."
02/01/2002 - "The different localization of Hdm2 (nucleoplasm) and p14(ARF) (nucleoli) observed in Hodgkin's tumors and cell lines is associated with the presence of short alternatively spliced transcripts of Hdm2 lacking the ARF-binding region and the nuclear export signal. "
|4.||Acute Myeloid Leukemia (Acute Myelogenous Leukemia)
11/01/2005 - "Mutations affecting the carboxylterminal domain of NPM occur in a significant percentage of adult patients with acute myeloid leukemia (AML), and these alterations create an additional nuclear export signal that relocalizes much of the protein from its normal nucleolar stores to the cytoplasm. "
08/03/2012 - "More than 50 mutations at the terminal exon of the NPM1 gene have been identified so far in acute myeloid leukemia; the mutated proteins are aberrantly and stably localized in the cytoplasm due to high destabilization of the NPM1 C-terminal domain and the appearance of a new nuclear export signal. "
07/01/2007 - "Creation of a nuclear export signal (NES) motif and loss of tryptophans (W) 288 and 290 (or 290 only) at the COOH terminus of nucleophosmin (NPM) are both crucial for NPM aberrant cytoplasmic accumulation in acute myelogenous leukemia (AML) carrying NPM1 mutations. "
|5.||T-Cell Leukemia (Leukemia, T Cell)
08/01/1996 - "Protein sequence requirements for function of the human T-cell leukemia virus type 1 Rex nuclear export signal delineated by a novel in vivo randomization-selection assay."
06/13/2003 - "Characterization of a nuclear export signal within the human T cell leukemia virus type I transactivator protein Tax."
09/01/1996 - "The human T-cell leukemia virus type 1 posttranscriptional trans-activator Rex contains a nuclear export signal."
|1.||Nuclear Localization Signals (Nuclear Localization Signal)
|4.||enhanced green fluorescent protein
|5.||Proteins (Proteins, Gene)
|8.||Trans-Activators (Trans-Acting Factor)