|1.||Jasmin, Bernard J: 10 articles (01/2016 - 01/2002)|
|2.||Davies, Kay E: 9 articles (06/2015 - 10/2002)|
|3.||Davies, K E: 8 articles (09/2007 - 02/2000)|
|4.||Zhang, Cheng: 6 articles (12/2014 - 04/2003)|
|5.||Khurana, Tejvir S: 6 articles (05/2013 - 08/2007)|
|6.||Rafael-Fortney, Jill A: 6 articles (11/2012 - 02/2005)|
|7.||Basu, Utpal: 5 articles (01/2015 - 08/2007)|
|8.||Delfín, Dawn A: 5 articles (01/2015 - 01/2011)|
|9.||Miura, Pedro: 5 articles (09/2011 - 06/2005)|
|10.||Lozynska, Olga: 5 articles (01/2011 - 08/2007)|
|1.||Duchenne Muscular Dystrophy (Muscular Dystrophy, Becker)
02/15/2004 - "Utrophin has been studied extensively in recent years in an effort to find a cure for Duchenne muscular dystrophy. "
01/01/2004 - "These results have important implications for future studies aiming to effect therapeutic utrophin up-regulation in Duchenne muscular dystrophy patients."
10/01/2002 - "Previous studies on transgenic mice indicate that upregulation of utrophin protein may offer a potential treatment strategy for Duchenne muscular dystrophy. "
01/01/2016 - "Upregulation of utrophin A is an attractive therapeutic strategy for treating Duchenne muscular dystrophy (DMD). "
06/01/2015 - "SMT C1100 is a small molecule utrophin modulator in development to treat Duchenne muscular dystrophy. "
|2.||Muscular Dystrophies (Muscular Dystrophy)
04/01/2015 - "We show that sarcospan-mediated amelioration of muscular dystrophy in DMD mice is dependent on the presence of both utrophin and α7β1 integrin, even when they are individually expressed at therapeutic levels. "
04/01/2015 - "In order to investigate the mechanisms underlying sarcospan 'rescue' of muscular dystrophy, we created double-knockout mice to test the contributions of utrophin or α7 integrin. "
01/01/2015 - "We postulated that P-188 NF might protect diaphragm muscle membranes from contraction-induced injury in mdx and mdx/utrophin-/- (dko) muscular dystrophy models. "
08/02/2011 - "We have used site-directed spin labeling and pulsed electron paramagnetic resonance to resolve a controversy concerning the structure of the utrophin-actin complex, with implications for the pathophysiology of muscular dystrophy. "
01/01/2011 - "Differential requirement for utrophin in the induced pluripotent stem cell correction of muscle versus fat in muscular dystrophy mice."
04/01/2015 - "While they do not genetically mirror human DMD, mdx:utrophin(+/-) mice may be a more useful animal model than mdx or dko mice for investigating long-term efficacy of potential treatments when fibrosis or muscle function is the focus. "
09/15/2015 - "In summary, our results demonstrate an inverse correlation between the level of muscle fibrosis and the level of utrophin and that of the number of revertant myofibers. "
02/01/2011 - "The DMD mouse models, mdx mice and mdx mice with haploinsufficiency of the utrophin gene (mdx/utrn(+/-) ), display progressive diaphragm fibrosis. "
11/01/2007 - "Surprisingly, we observed loss of skeletal muscle and accelerated fibrosis and adipogenesis in 1-year-old mdx mice transgenically overexpressing ADAM12 (ADAM12(+)/mdx mice), even though their utrophin levels were mildly elevated compared with age-matched controls. "
09/15/2015 - "Inhibition of muscle fibrosis results in increases in both utrophin levels and the number of revertant myofibers in Duchenne muscular dystrophy."
02/01/2013 - "Reducing inflammation or increasing utrophin expression can alleviate DMD pathology. "
04/01/2005 - "Factors associated with induced chronic inflammation in mdx skeletal muscle cause posttranslational stabilization and augmentation of extrasynaptic sarcolemmal utrophin."
01/15/2008 - "Haploinsufficiency of utrophin gene worsens skeletal muscle inflammation and fibrosis in mdx mice."
09/08/2000 - "In addition, in mature mdx mice, there was significantly greater transgene persistence and reduced inflammation with utrophin compared to dystrophin gene transfer. "
02/01/2013 - "The aims of this study were to identify an active dose of resveratrol in mdx mice and examine if this dose decreased inflammation and increased utrophin expression. "
01/01/2012 - "Resveratrol administration (100 mg/kg/day) resulted in improved fatigue resistance, but did not achieve significant increases in utrophin expression. "
08/01/2002 - "Comment on Connolly AM, et al. Three mouse models of muscular dystrophy: the natural history of strength and fatigue in dystrophin-, dystrophin/utrophin-, and laminin alpha2-deficient mice (Neuromuscul Disord 2001;11:703-712)."
11/01/2001 - "Three mouse models of muscular dystrophy: the natural history of strength and fatigue in dystrophin-, dystrophin/utrophin-, and laminin alpha2-deficient mice."
|3.||Carrier Proteins (Binding Protein)
|4.||Proteins (Proteins, Gene)
|8.||Protein Isoforms (Isoforms)
|9.||Creatine Kinase (Creatine Phosphokinase)
|1.||Transplantation (Transplant Recipients)