|1.||Ratcliffe, Peter J: 8 articles (04/2013 - 06/2003)|
|2.||Xiong, Yue: 3 articles (04/2015 - 06/2012)|
|3.||Guan, Kun-Liang: 2 articles (04/2015 - 06/2012)|
|4.||Ma, Shenghong: 2 articles (04/2015 - 06/2012)|
|5.||Ye, Dan: 2 articles (04/2015 - 06/2012)|
|6.||Yang, Hui: 2 articles (04/2015 - 06/2012)|
|7.||Her, Yeng F: 2 articles (01/2015 - 01/2015)|
|8.||Rocha, Sonia: 2 articles (09/2014 - 01/2012)|
|9.||Vissers, Margreet C M: 2 articles (08/2014 - 01/2014)|
|10.||Kuiper, Caroline: 2 articles (08/2014 - 01/2014)|
10/01/2009 - "Studies on hypoxia-sensitive pathways have identified a series of Fe(II)-dependent dioxygenases that regulate hypoxia-inducible factor (HIF) by prolyl and asparaginyl hydroxylation. "
10/03/2006 - "Studies on hypoxia-sensitive pathways have revealed a series of Fe(II)-dependent dioxygenases that regulate hypoxia-inducible factor (HIF) by prolyl and asparaginyl hydroxylation. "
01/01/2015 - "It has been suggested that this oncometabolite D-2HG via inhibition of αKG-dioxygenases is involved in multiple functions such as epigenetic modifications or hypoxia responses. "
01/01/2012 - "Importantly, although downregulation of PEDF was induced by inhibition of 2-oxoglutarate-dependent dioxygenases, it was independent of the hypoxia inducible factor (HIF), a key mediator of the adaptation to hypoxia. "
04/01/2007 - "It has been proposed that the associated accumulation of fumarate competitively inhibits the 2-oxoglutarate-dependent dioxygenases that regulate hypoxia-inducible factor (HIF), thus activating oncogenic hypoxia pathways. "
01/22/2015 - "Cumulatively, our data demonstrate that CRL4(VprBP) is a critical regulator of TET dioxygenases during development and in tumor suppression. "
01/01/2015 - "In cancer, mutant IDH1/2 reduces α-KG to D2-hydroxyglutarate (D2-HG) disrupting α-KG-dependent dioxygenases. "
08/01/2014 - "Regulation of the 2-oxoglutarate-dependent dioxygenases and implications for cancer."
01/01/2011 - "2-Oxoglutarate-dependent dioxygenases therefore provide a link between altered metabolism and cancer."
01/01/2007 - "Though tremendous progress has been made in elucidating the mechanisms underlying O(2)-dependent regulation of HIF by Fe(II)- and 2-oxoglutarate-dependent dioxygenases, HIF induction can be uncoupled from these modes of regulation in diseases such as cancer. "
05/10/2013 - "Ascorbate (vitamin C) is best known for its role in scurvy, in which the hydroxylation of collagen catalyzed by dioxygenases is incomplete due to ascorbate deficiency. "
01/01/2012 - ""Ascorbic" literally means "against scurvy", and scurvy is known to be mainly due to the inactivation of some important dioxygenases involved in the synthesis of a few key molecules, including different collagen forms (De Tullio MC (2004) How does ascorbic acid prevent scurvy? "
12/01/2013 - "Vitamin C, a micronutrient known for its anti-scurvy activity in humans, promotes the generation of induced pluripotent stem cells (iPSCs) through the activity of histone demethylating dioxygenases. "
07/01/2002 - "Tyrosinemia I, a model for human diseases mediated by 2-oxoacid-utilizing dioxygenases: hepatotoxin suppression by NTBC does not normalize hepatic collagen metabolism."
07/01/2002 - "Medical treatment of tyrosinemia I relies on the herbicide NTBC [Orfadin 2-(2-nitro-4-trifluoromethylbenzoyl)-cyclohexane-1,3-dione], an inhibitor of plant and mammalian 2-oxoacid-utilizing dioxygenases with a collective catalytic cycle ('HAG' mechanism). "
|2.||Transcription Factors (Transcription Factor)
|4.||Succinic Acid (Succinate)
|7.||DNA (Deoxyribonucleic Acid)
|9.||Mixed Function Oxygenases (Monooxygenases)
|10.||alpha-ketoglutaric acid (alpha-ketoglutarate)
|3.||Drug Therapy (Chemotherapy)