HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Limb-Girdle Muscular Dystrophies (Limb-Girdle Muscular Dystrophy)

A heterogenous group of inherited muscular dystrophy that can be autosomal dominant or autosomal recessive. There are many forms (called LGMDs) involving genes encoding muscle membrane proteins such as the sarcoglycan (SARCOGLYCANS) complex that interacts with DYSTROPHIN. The disease is characterized by progressing wasting and weakness of the proximal muscles of arms and legs around the HIPS and SHOULDERS (the pelvic and shoulder girdles).
Also Known As:
Limb-Girdle Muscular Dystrophy; Muscular Dystrophy, Limb-Girdle; Muscular Dystrophies, Limb-Girdle; Limb-Girdle Syndrome; Myopathic Limb-Girdle Syndrome; Limb Girdle Muscular Dystrophies; Limb Girdle Muscular Dystrophy; Muscular Dystrophies, Limb Girdle; Muscular Dystrophy, Limb Girdle
Networked: 800 relevant articles (6 outcomes, 39 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Duchenne Muscular Dystrophy (Muscular Dystrophy, Becker)
2. Emery-Dreifuss Muscular Dystrophy (Scapuloperoneal Muscular Dystrophy)
3. Infections
4. Body Weight (Weight, Body)
5. Hypoxia (Hypoxemia)

Experts

1. Straub, Volker: 20 articles (01/2021 - 11/2004)
2. Richard, Isabelle: 18 articles (01/2022 - 01/2007)
3. Nigro, Vincenzo: 16 articles (01/2019 - 11/2003)
4. Bushby, Kate: 16 articles (01/2018 - 02/2004)
5. Muntoni, Francesco: 16 articles (01/2018 - 03/2002)
6. McNally, Elizabeth M: 13 articles (01/2022 - 10/2005)
7. Barresi, Rita: 13 articles (01/2021 - 11/2002)
8. Angelini, Corrado: 13 articles (01/2020 - 11/2003)
9. Vissing, John: 13 articles (01/2020 - 03/2012)
10. Lochmüller, Hanns: 12 articles (01/2022 - 05/2005)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Limb-Girdle Muscular Dystrophies:
1. Proteins (Proteins, Gene)FDA Link
2. Sarcoglycans (beta Sarcoglycan)IBA
3. DystrophinIBA
4. Karyopherins (Importin)IBA
5. dystrobrevinIBA
6. Oxygen (Dioxygen)IBA
7. CalpainIBA
8. Peptide Hydrolases (Proteases)FDA Link
9. MyostatinIBA
10. Dystroglycans (Dystroglycan)IBA

Therapies and Procedures

1. Intranasal Administration
2. Intermittent Positive-Pressure Ventilation
3. Therapeutics
4. Resistance Training
5. Cell Transplantation