|1.||Xia, Ying: 2 articles (01/2011 - 08/2008)|
|2.||Herring, Amy H: 1 article (02/2014)|
|3.||Bensen, Jeannette T: 1 article (02/2014)|
|4.||O'Brien, Katie M: 1 article (02/2014)|
|5.||Cole, Stephen R: 1 article (02/2014)|
|6.||Poole, Charles: 1 article (02/2014)|
|7.||Millikan, Robert C: 1 article (02/2014)|
|8.||Engel, Lawrence S: 1 article (02/2014)|
|9.||Cao, Jiang: 1 article (01/2014)|
|10.||Huang, Qin: 1 article (01/2014)|
|1.||Breast Neoplasms (Breast Cancer)
01/01/2014 - "The associations between mitogen-activated protein kinase kinase kinase 1 (MAP3K1) SNPs rs889312 A>C, rs16886165 T>G and breast cancer risk have been widely evaluated, but the results were inconsistent. "
01/01/2014 - "Association between mitogen-activated protein kinase kinase kinase 1 polymorphisms and breast cancer susceptibility: a meta-analysis of 20 case-control studies."
01/01/2014 - "MAP3K1 protein expression level in breast cancer cells was higher than that in normal mammary gland cells. "
04/01/2011 - "Published data on the association between mitogen-activated protein kinase kinase kinase 1 (MAP3K1) gene rs889312 polymorphism and breast cancer risk are inconclusive. "
04/01/2011 - "Association between mitogen-activated protein kinase kinase kinase 1 rs889312 polymorphism and breast cancer risk: evidence from 59,977 subjects."
12/01/2011 - "To assess possible effects of apigenin on migration of bladder smooth muscle (SM) cell, we isolated SM cells from peri-cancer tissue of human bladder and established a cell model that was capable to overexpress transiently MEKK1 (MEK kinase 1). "
12/01/2008 - "Among 26 statistically reliable genes, the expression of apoptosis related genes such as ADAM22, Bax, BCL2L14, and UBD, as well as tumor suppressor-related genes like Axin2 and ATF, and also mitogen-activated protein kinase-related genes like mitogen-activated protein kinase kinase kinase 1, histamine receptor, and RAB24, were significantly changed in cells responsive to pressure-induced oxidative stress."
03/01/2004 - "This report describes several signaling pathways that are potential targets for inflammation and cancer, including those that involve the following signaling molecules: Jun N-terminal kinase, cyclin-dependent kinases, hypoxia-inducible factor, p21-activated kinases, MEK kinase 1, phosphoinositide 3-kinases, myc, p53, Smad, hedgehog, nuclear factor-kB and G protein. "
|3.||XY Disorders of Sex Development 46 (Male Pseudohermaphroditism)
10/01/2013 - "Recently, mitogen activated protein kinase kinase kinase 1 (MAP3K1) gene was found to be associated with 46, XY disorders of sex development (DSD). "
01/01/2011 - "Recently, cases of familial and spontaneous 46,XY disorders of sex development (DSD) have been attributed to mutations in the human gene encoding mitogen-activated protein kinase kinase kinase 1, MAP3K1, a component of the mitogen-activated protein kinase (MAPK) signal transduction pathway. "
|4.||Prostatic Neoplasms (Prostate Cancer)
07/01/1999 - "Specifically, we have studied the biological effects of mitogen-activated protein kinase kinase kinase 1 (MEKK1) expression in prostate cancer cells. "
07/01/1999 - "Mitogen-activated protein kinase kinase kinase 1 activates androgen receptor-dependent transcription and apoptosis in prostate cancer."
04/01/2002 - "By expressing a dominant-active form of mitogen-activated protein kinase kinase kinase 1, by exposure to tumor necrosis factor alpha, or by overexpression of p50/p65, we show that NF-kappa B activates a transcription regulatory element of the prostate-specific antigen (PSA)-encoding gene, a marker for prostate cancer development, treatment, and progression. "
|5.||Melanoma (Melanoma, Malignant)
09/17/2013 - "Moreover, for infrequently mutated genes often disregarded by current methods, we discovered recurrent mitogen-activated protein kinase kinase kinase 1 (Map3k1)-activating insertions in our screen, mirroring recurrent MAP3K1 up-regulation in human melanomas. "
04/01/2007 - "Inhibition of nuclear factor-kappaB augments antitumor activity of adenovirus-mediated melanoma differentiation-associated gene-7 against lung cancer cells via mitogen-activated protein kinase kinase kinase 1 activation."
|1.||Protein Kinases (Protein Kinase)
|3.||Estrogen Receptor alpha
|5.||GTP-Binding Proteins (G-Protein)
|6.||Cyclin-Dependent Kinases (cdk Proteins)
|7.||Prostate-Specific Antigen (Semenogelase)
|8.||NF-kappa B (NF-kB)
|9.||Tumor Suppressor Protein p53
|10.||Urokinase-Type Plasminogen Activator (Urokinase)