Polyketide Synthases

Large enzyme complexes composed of a number of component enzymes that are found in STREPTOMYCES which biosynthesize MACROLIDES and other polyketides.

Also Known As:

6-Deoxyerythronolide-B Synthase; Epothilone Polyketide Synthase; Erythromycin Polyketide Synthase; Griseusin Polyketide Synthase; Niddamycin Polyketide Synthase; Polyketide Synthase L1; Polyketide Synthase WA; Rifamycin Polyketide Synthase; Sterigmatocystin Polyketide Synthase; Type I Polyketide Synthase; Type II Polyketide Beta-Ketoacyl Synthase; Urdamycin Polyketide Synthase; WdPKS1 Protein; WhiE Polyketide Synthase; 6 Deoxyerythronolide B Synthase; Polyketide Synthase, Epothilone; Polyketide Synthase, Erythromycin; Polyketide Synthase, Griseusin; Polyketide Synthase, Niddamycin; Polyketide Synthase, Rifamycin; Polyketide Synthase, Sterigmatocystin; Polyketide Synthase, Urdamycin; Polyketide Synthase, WhiE; Protein, WdPKS1; Synthase L1, Polyketide; Synthase WA, Polyketide; Synthase, 6-Deoxyerythronolide-B; Synthase, Epothilone Polyketide; Synthase, Erythromycin Polyketide; Synthase, Griseusin Polyketide; Synthase, Niddamycin Polyketide; Synthase, Polyketide; Synthase, Rifamycin Polyketide; Synthase, Sterigmatocystin Polyketide; Synthase, Urdamycin Polyketide; Synthase, WhiE Polyketide; Synthases, Polyketide; Type II Polyketide Beta Ketoacyl Synthase; Polyketide Synthase

Networked: 62 relevant articles (0 outcomes, 4 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Ligases: 5553
    - Carbon-Carbon Ligases
      - Polyketide Synthases: 62
        Arabidopsis LAP5 protein
        Arabidopsis LAP6 protein
        Aspergillus terreus lovastatin nonaketide synthase
        Gerbera hybrida GASCL1 chalcone synthase
        Gerbera hybrida GASCL2 chalcone synthase
        Mycobacterium tuberculosis H37Rv PKS15 protein
        Mycobacterium tuberculosis polyketide synthase Pks13
        polyketide beta-ketoacylsynthase
        Streptomyces coelicolor 1,3,6,8-tetrahydroxynaphthalene synthase
        zebrafish pks1 protein
  - Multienzyme Complexes: 8
    - Polyketide Synthases: 62

Experts

1.	Khosla, Chaitan: 3 articles (01/2021 - 01/2016)
2.	Liu, Corey W: 3 articles (01/2021 - 01/2016)
3.	Lynch, Stephen R: 3 articles (01/2021 - 01/2016)
4.	Stinear, Timothy P: 3 articles (01/2018 - 11/2010)
5.	Yuet, Kai P: 2 articles (01/2021 - 01/2020)
6.	Gavalda, Sabine: 2 articles (12/2020 - 05/2009)
7.	Guilhot, Christophe: 2 articles (12/2020 - 04/2009)
8.	Mourey, Lionel: 2 articles (12/2020 - 05/2009)
9.	Chakraborty, Kajal: 2 articles (08/2020 - 05/2020)
10.	Kizhakkekalam, Vinaya Kizhakkepatt: 2 articles (08/2020 - 05/2020)

Related Diseases

1.	Infections 11/01/2014 - "Polyketide synthase (PKS) reduces fusion of Legionella pneumophila-containing vacuoles with lysosomes and contributes to bacterial competitiveness during infection." 08/01/2011 - "We have identified two polyketide synthase (PKS) encoding genes, BcPKS6 and BcPKS9, that are up-regulated during tomato leaf infection. " 01/01/2020 - "Here, we identified a putative polyketide synthase-nonribosomal peptide synthetase (PKS-NRPS) gene cluster (phm) that was upregulated in the pathogen Parastagonospora nodorum during its infection on wheat. " 01/01/2018 - "To understand the impact of the putative virulence factor melanin on the infection, we generated a polyketide synthase (PKS1) mutant using CRISPR/Cas9 resulting in a melanin deficient strain. " 08/15/2015 - "The compound enables iron scavenging capabilities upon host infection and is biosynthesized by a nonribosomal peptide synthetase featuring a polyketide synthase module. "
2.	Starvation 09/30/2022 - "Furthermore, the pfaB gene involved in the polyketide synthase (PKS) pathway was significantly upregulated under nitrogen starvation. " 01/01/2017 - "The aim of this study was to sequence the full transcriptome of the dinoflagellate Amphidinium carterae in both nitrogen-starved and -replete culturing conditions (1) to evaluate the response to nitrogen starvation at the transcriptional level, (2) to look for possible polyketide synthases (PKSs) in the studied clone (genes that may be involved in the synthesis of bioactive compounds), (3) if present, to evaluate if nutrient starvation can influence PKS expression, (4) to look for other possible enzymes of biotechnological interest and (5) to test strain cytotoxicity on human cell lines. " 07/24/2020 - "Phosphate starvation was selected because it is known to induce toxin production for other Alexandrium spp. Results showed the presence of three transcripts related to saxitoxin synthesis (sxtA, sxtG and sxtU), and others potentially related to the synthesis of additional toxic compounds (e.g., 44 transcripts annotated as "polyketide synthase"). " 09/01/2003 - "Modular polyketide synthase and TonB proteins are normally expressed under iron-starvation and are known to be involved in biosynthesis and transport of siderophores respectively. " 02/01/2010 - "The induction by salt starvation, but not by sucrose, correlated with an increase in messenger RNA levels of gene bik1, encoding a polyketide synthase of the bikaverin pathway."
3.	Male Infertility (Male Sterility) 04/02/2022 - "In this study, we cloned the sesame POLYKETIDE SYNTHASE A (SiPKSA) and examined its function in male sterility. "
4.	Bacterial Infections (Bacterial Infection) 05/01/2020 - "Antibacterial activity study combined with the results of amplified genes coding for polyketide synthase and nonribosomal peptide synthetase showed that these marine symbiotic bacteria had a promising broad-spectrum activity, and therefore, could be used against the emerging dilemma of antibiotic-resistant bacterial infections."
5.	Tuberculosis (Tuberculoses) 11/05/2023 - "Targeting polyketide synthase 13 for the treatment of tuberculosis." 06/01/2023 - "tuberculosis Polyketide Synthase 13." 04/01/2009 - "tuberculosis), which encodes a putative polyketide synthase, resulted in the concomitant abrogation of the production of both PMB-FA and LOS in the mutant strain. " 03/05/2021 - "We previously reported a series of coumestans-a naturally occurring tetracyclic scaffold containing a δ-lactone-that effectively target the thioesterase domain of polyketide synthase 13 (Pks13) in Mycobacterium tuberculosis (Mtb), resulting in superior anti-tuberculosis (TB) activity. " 05/29/2009 - "tuberculosis polyketide-synthase-associated adenylation enzymes possessing such activity. "

Related Drugs and Biologics

1.	Anti-Bacterial Agents (Antibiotics)
2.	non-ribosomal peptide synthase
3.	Enzymes
4.	Lipids
5.	Nitrogen
6.	Polyketides
7.	Peptide Synthases
8.	Hydro-Lyases (Dehydratases)
9.	colibactin
10.	Proteins (Proteins, Gene)

Related Therapies and Procedures

1.	Therapeutics