|1.||Liver Cirrhosis (Hepatic Cirrhosis)
|3.||Obstructive Jaundice (Cholestatic Jaundice)
|4.||Hepatolenticular Degeneration (Wilson's Disease)
|1.||Lasseter, Kenneth C: 7 articles (11/2014 - 10/2003)|
|2.||Curley, Steven A: 7 articles (01/2014 - 05/2004)|
|3.||Vauthey, Jean-Nicolas: 7 articles (01/2014 - 05/2004)|
|4.||Wagner, John A: 5 articles (11/2014 - 01/2009)|
|5.||Abdalla, Eddie K: 5 articles (08/2012 - 05/2004)|
|6.||Staley, Charles A: 4 articles (10/2014 - 04/2011)|
|7.||Kooby, David A: 4 articles (10/2014 - 04/2011)|
|8.||Maithel, Shishir K: 4 articles (10/2014 - 04/2011)|
|9.||Tzeng, Ching-Wei D: 4 articles (01/2014 - 08/2012)|
|10.||Aloia, Thomas A: 4 articles (01/2014 - 08/2012)|
07/01/2013 - "When the patients who underwent hepatic pedicle occlusion by Pringle’s maneuver over 15min were analyzed, the frequency of postoperative liver insufficiency (p=0.028), serum total bilirubin levels on days 5 (p=0.025) and 7 (p=0.032) preoperatively, and the maximum value of postoperative serum total bilirubin (p=0.040) were significantly greater in the control than in the SAMe group. "
03/01/2008 - "TAA rats, selected for the study, had confirmed liver insufficiency: their plasma bilirubin concentrations were about 3 times higher, the prothrombin time was 50% longer and they consumed voluntarily 3 times more alcohol than the control animals. "
11/01/2013 - "Definition of hepatic insufficiency was peak postoperative serum total bilirubin level of more than 7 mg/dL or, in jaundiced patients, an increasing bilirubin level on day 5 or thereafter. "
10/01/2009 - "Liver volumetry accounted for partial resection of segment IV. Liver insufficiency was defined as peak postoperative serum bilirubin >7 mg/dL. "
08/01/2009 - "Hepatic insufficiency was defined as a postoperative rise in bilirubin of 5 mg/dl above the preoperative level that persisted for >5 days postoperatively. "
|2.||Biological Markers (Surrogate Marker)IBA
05/01/2014 - "In the event that a patient with hepatic insufficiency is selected for HSCT, dosage adjustments may be considered; however, no reliable endogenous biomarkers can serve as a guide for adjustments. "
07/01/2012 - "To date, no study has compared the efficacy of RTX combined with PEG-IFN/RBV on biomarkers of liver insufficiency in patients with severe liver fibrosis. "
06/01/2015 - "The carriers of IL6 -174C/C genotypes were prone to the increased levels of biochemical markers and acute kidney and liver insufficiency. "
08/01/2008 - "The serum concentrations of prohepcidin were compared with the degree of liver insufficiency and biochemical markers of iron metabolism. "
01/01/2014 - "In this secondary analysis of consecutive ED patients with CAP from a large multicentre antibiotic stewardship trial, we used adjusted multivariate regression models to determine the magnitude and statistical significance of differences in mean baseline concentrations of five biomarkers (procalcitonin [PCT], C-reactive protein [CRP], white blood cells count [WBC], proadrenomedullin [ProADM], copeptin) associated with six pre-analytic factors (antibiotic or corticosteroid pretreatment, age, gender, chronic renal failure or chronic liver insufficiency). "
|3.||Anti-Bacterial Agents (Antibiotics)IBA
11/03/1982 - "The use of HOT, antibiotics and selective surgery as treatment of metabolic disturbances effectively improved the patient's general condition, and HOT also proved effective in the treatment of hepatic insufficiency."
05/01/1976 - "Special emphasis is laid upon the hazard of prescribing such drugs in certain conditions, including in particular the presence of renal or hepatic insufficiency, and the importance of laboratory assessment of new antibiotics for ototoxicity before undertaking clinical trials."
01/01/1993 - "When renal function is impaired and there is an increased volume of distribution due to ascites, as frequently observed in severe liver insufficiency, the elimination half-life of most antibiotics is markedly prolonged, resulting in potential side effects due to drug accumulation. "
05/01/2004 - "Our recommendation, based on prophylaxis with antibiotics during digestive bleeding in cirrhosis and in acute hepatic insufficiency, is to extend this prophylaxis to alcoholic hepatitis, in its severe form, in order to prevent bacterial infections and early death."
11/01/1989 - "The patient manifested acute renal failure, respiratory failure, hepatic insufficiency, and high-output septic shock requiring invasive hemodynamic monitoring, peritoneal dialysis, mechanical ventilation, and broad spectrum intravenous antibiotics. "
|4.||Triptorelin (Trelstar)FDA Link
10/01/1997 - "The total clearance of triptorelin decreased with increasing renal impairment, and was even lower in patients with hepatic insufficiency (geometric mean CLtot: 210 ml min(-1), 113 ml min(-1), 86.8 ml min(-1) and 57.3 ml min(-1) for Groups I, II, III and IV, respectively). "
10/01/1997 - "Pharmacokinetics of triptorelin after intravenous bolus administration in healthy males and in males with renal or hepatic insufficiency."
10/01/1997 - "This was an open study to determine the pharmacokinetics of a single i.v. bolus dose of 0.5 mg triptorelin acetate in four groups of six male subjects; namely in healthy subjects (Group I), in patients with varying degrees of renal insufficiency (Groups II and III), and in patients with hepatic insufficiency (Group IV). "
|5.||Penicillamine (Cuprimine)FDA Link
06/01/2001 - "To report the features of Wilson's disease with severe hepatic insufficiency in a series of 17 patients and, during the second period of the study, to assess the efficacy of a policy consisting of early administration of D-penicillamine. "
06/01/2001 - "Wilson's disease with severe hepatic insufficiency: beneficial effects of early administration of D-penicillamine."
06/01/2001 - "In most patients with Wilson's disease heralded by severe hepatic insufficiency and without encephalopathy at admission, early administration of D-penicillamine was associated with survival without transplantation. "
|6.||Insulin-Like Growth Factor I (IGF-1)IBA
01/01/2013 - "rhIGF-1 treatment does not seem to be able to replace the physiological action of IGF-1 in patients with MOPD II and hepatic insufficiency, however, it seems to preserve the typical growth pattern of MOPD II patients, avoiding a further widening of the growth deficiency in these subjects."
03/01/1993 - "In addition, the IGF-1 levels reflect the degree of hepatic insufficiency and, thus, seem to provide new prognostic information."
01/01/2013 - "In consideration of the low levels of insulin-like growth factor-1 (IGF-1) as well as of hepatic insufficiency, we started the treatment with recombinant human IGF-1 (rhIGF-1) at the dose of 0.04 mg/kg in 2 doses/day, with an increase of 0.04 mg/kg after 1 week until the maximum dose of 0.12 mg/kg. We observed an early response to rhIGF-1 treatment, with a shift of height velocity from 1.8 cm/year (-4.6 SDS) at 4 cm/year (-1.9 SDS), and an increase in bone age of 1.5 years during the first 6 months. "
02/01/1998 - "We conclude that LT in patients with severe hepatic insufficiency enhances the potential for normal cell growth and replication by restoring serum IGF-I, IGF-II, and IGFBP-3 concentrations to normal concomitantly with the improvement in hormonal and nutritional status."
|7.||Ondansetron (Zofran)FDA LinkGeneric
03/01/1996 - "A reduction in the clearance of ondansetron is associated with increasing degrees of hepatic insufficiency; therefore, patients with severe hepatic impairment (Pugh score of > 9) should have their daily dose of ondansetron limited to 8 mg (or 0.15 mg/kg)."
03/01/1996 - "After a single, oral dose of ondansetron, mean absolute bioavailability increased markedly with increased hepatic insufficiency (approaching 100% in the group with severe hepatic impairment versus 66% for control subjects). "
03/01/1996 - "The pharmacokinetics of ondansetron in patients with different degrees of hepatic insufficiency (N = 12 with hepatic impairment, as categorized by Pugh's classification method) were assessed and the results compared with results for age- and gender-matched control subjects with normal liver function (n = 12). "
03/01/1996 - "Pharmacokinetics of ondansetron in patients with hepatic insufficiency."
08/01/1992 - "Ondansetron clearance decreases and half-life increases in patients with severe hepatic insufficiency. "
|8.||Cefoperazone (Cefoperazone Sodium)FDA Link
01/23/1982 - "Extrarenal clearance of cefoperazone was significantly lower in our patients (15.8 ml/min), as it is in patients with hepatic insufficiency (7.3 ml/min), than in the control group (59.4) ml/min). "
01/01/1989 - "Adjustment of the dose of cefoperazone in cases of severe hepatic insufficiency does not appear to be necessary provided that renal function is normal."
01/23/1982 - "Mean serum concentration of cefoperazone determined by a microbiological method) measured after a two-hour intravenous perfusion of 2 g cefoperazone was 198.6 microgram/lm; this level is higher than the mean level measured in normal subjects (134 microgram/ml) but lower than the mean level measured in patients with hepatic insufficiency (208 microgram/ml). "
|9.||Adrenal Cortex Hormones (Corticosteroids)IBA
|10.||essential 303 forteIBA
01/01/1963 - "[On the therapy of various forms of liver insufficiency by "essential" phospholipids]."
06/01/1978 - "The efficacy of the drug "essentiale" is discussed on the basis of observation over 34 patients suffering from ischemic heart disease with functional hepatic insufficiency and types IIa and IIb hyperlipoproteinemia. "
11/01/2015 - "Defining Post Hepatectomy Liver Insufficiency: Where do We stand?"
01/01/2015 - "The most significant risk following major hepatectomy is postoperative liver insufficiency. "
10/01/2014 - "Early identification of patients at increased risk for hepatic insufficiency, complications and mortality after major hepatectomy."
10/01/2014 - "Hypophosphataemia after major hepatectomy and the risk of post-operative hepatic insufficiency and mortality: an analysis of 719 patients."
09/07/2014 - "Low immediate postoperative platelet count is associated with hepatic insufficiency after hepatectomy."
11/01/1997 - "We evaluated men undergoing liver transplantation to determine whether chronic hepatic insufficiency affected serum PSA levels and whether improved hepatic function altered serum PSA levels. "
07/01/1983 - "[Treatment of acute liver insufficiency by heterotopic liver transplantation (experimental study)]."
04/01/2014 - "Orthotropic Liver transplantation (OLT) is a conventional management for end-stage acute or chronic liver insufficiency, but the shortage of donor organs continues to be the restrictive factor throughout the world. "
06/01/2009 - "However acute hepatic insufficiency has been reported including a few cases treated by liver transplantation but with poor results suggesting that conservative management is preferable. "
01/01/2009 - "Extended liver resection or split liver transplantation is still associated with high morbidity and mortality because of postoperative liver insufficiency. "
01/01/1990 - "The aim of this work was to assess the effect of intrasplenic liver cell transplantation (ILCT) on hepatic insufficiency induced by a terminolateral portocaval shunt (PCS) in rats. "
09/01/1988 - "In the present study, we evaluated the efficacy of liver cell transplantation in providing metabolic support during acute liver insufficiency induced by 90% partial hepatectomy in rats. "
07/01/2008 - "The bioartificial liver (BAL) represents a promising approach to cell transplantation without immunosuppression as a method to support patients with hepatic insufficiency. "
01/01/1988 - "An effect of previous sclerotherapy was observed during the next therapeutic session in 18, and eight patients died from progressive hepatic insufficiency. "
01/01/1990 - "Repeated sclerotherapy proved effective in 10 patients, 3 patients died from continuing bleeding and hepatic insufficiency."
03/01/1999 - "Due to exclusion criteria of: gastroduodenal ulcers (n = 5), diverticulosis (n = 1), hepatic insufficiency (n = 10), hepatocellular carcinoma (n = 4), death before randomization (n = 6), age over 70 (n = 1) and denial of consent to participate in the study (n = 1), 43 patients could be randomized, 21 for sclerotherapy and 22 for the control group. "
07/01/2012 - "Adult ICU patients with confirmed C/IC meeting ≥ 1 of the following criteria were enrolled: post-abdominal surgery, solid tumour, renal/hepatic insufficiency, solid organ transplant, neutropaenia, and age ≥ 65 years. "
08/01/2008 - "Hepatitis B virus (HBV) recurrence may result in hepatic insufficiency or dysfunction of liver grafts. "
12/01/1999 - "Pre-transplant evaluation should aim to rule out neurological disease, which may be difficult to differentiate from signs accompanying liver insufficiency. "
06/01/1999 - "A teenage boy who received a small graft (0.9% of his weight) presented initially with hepatic insufficiency without encephalopathy. "
03/01/1994 - "Of the seven patients given transplants for hepatic insufficiency who manifested neurological and/or psychiatric manifestations at the time of orthotopic liver transplantation, four showed improvement of these symptoms. "