MAP Kinase Kinase 2

A 44 kDa mitogen-activated protein kinase kinase with specificity for MITOGEN-ACTIVATED PROTEIN KINASE 1 and MITOGEN-ACTIVATED PROTEIN KINASE 3.

Also Known As:

Kinase Activator Kinase MEK2; MAP2K2 Protein; MAPK Extracellular Signal-Regulated Kinase 2; MAPK Kinase 2; MAPK-ERK Kinase 2; MEK-2 (MAPK Extracellular Signal-Regulated Kinase 2); MEK2 (MAPK Extracellular Signal-Regulated Kinase 2); Mitogen-Activated Protein Kinase Kinase 2; MAPK ERK Kinase 2; MAPK Extracellular Signal Regulated Kinase 2; Mitogen Activated Protein Kinase Kinase 2

Networked: 12 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Egami, Hiroshi: 6 articles (08/2005 - 01/2004)
2.	Hirota, Masahiko: 6 articles (08/2005 - 01/2004)
3.	Ishikawa, Shinji: 6 articles (08/2005 - 01/2004)
4.	Ogawa, Michio: 6 articles (08/2005 - 01/2004)
5.	Tan, Xiaodong: 6 articles (08/2005 - 01/2004)
6.	Kurizaki, Takashi: 5 articles (08/2005 - 01/2004)
7.	Takai, Eiji: 3 articles (05/2004 - 01/2004)
8.	Nakagawa, Masahide: 2 articles (12/2004 - 11/2004)
9.	Kamohara, Hidenobu: 2 articles (11/2004 - 01/2004)
10.	Tamori, Yasuhiro: 2 articles (05/2004 - 04/2004)

Related Diseases

1.	Pancreatic Neoplasms (Pancreatic Cancer) 01/01/2004 - "Involvement of the mitogen-activated protein kinase kinase 2 in the induction of cell dissociation in pancreatic cancer." 08/01/2005 - "In our previous study, dissociation factor (DF) and mitogen-activated protein kinase kinase 2 (MEK2) were isolated as factors relating to cancer cell dissociation in pancreatic cancer cells. " 05/01/2004 - "Mitogen-activated protein kinase kinase 2 (MEK2) was detected as an invasion-metastasis related factor between highly invasive (PC-1.0) and weakly invasive (PC-1) pancreatic cancer cell lines in our previous study. " 12/01/2004 - "Mitogen-activated protein kinase kinase 2 (MEK2) was isolated previously as a potential factor related to cancer cell dissociation in highly (PC-1.0) and weakly (PC-1) invasive pancreatic cancer cells. " 11/01/2004 - "In our previous investigations, mitogen-activated protein kinase kinase 2 (MEK2)/extracellular signal-regulated kinase 2 (ERK2) signaling pathway was found to be correlated with the cell dissociation induced by dissociation factor (DF) in pancreatic cancer cells. "
2.	Neoplasms (Cancer) 01/01/2021 - "Among them, mitogen-activated protein kinase kinase 2 (MEK2) is the most crucial upstream signaling pathway of ERK1/2 cascade as a therapeutic target for overcoming Ras-driven cancers. " 08/01/2005 - "In our previous study, dissociation factor (DF) and mitogen-activated protein kinase kinase 2 (MEK2) were isolated as factors relating to cancer cell dissociation in pancreatic cancer cells. " 01/01/2016 - "Here, the gene expression profiles of TMZ-resistant and TMZ-sensitive samples were compared by microarray analysis, and mitogen-activated protein kinase kinase 2 (MEK2) was upregulated specifically in resistant glioma cells but not in sensitive tumor cells or non-tumor tissues. " 12/01/2004 - "Mitogen-activated protein kinase kinase 2 (MEK2) was isolated previously as a potential factor related to cancer cell dissociation in highly (PC-1.0) and weakly (PC-1) invasive pancreatic cancer cells. " 04/01/2004 - "Mitogen-activated protein kinase kinase 2 (MEK2), the upstream kinase of extracellular signal-regulated kinase 1/2 (ERK1/2) was previously isolated as cancer cell dissociation related factor. "
3.	Neoplasm Metastasis (Metastasis) 05/01/2004 - "Mitogen-activated protein kinase kinase 2 (MEK2) was detected as an invasion-metastasis related factor between highly invasive (PC-1.0) and weakly invasive (PC-1) pancreatic cancer cell lines in our previous study. " 01/01/2004 - "In our previous investigation, mitogen-activated protein kinase kinase 2 (MEK2) was detected as a factor which was correlated to the potential of invasion-metastasis. "
4.	Acute Lung Injury 01/01/2022 - "In preclinical acute lung injury (ALI) models, inhibition of MAP2K1 (MAPK kinase 1)/MAP2K2 (MAPK kinase 2) improves measures of ALI. "
5.	Colorectal Neoplasms (Colorectal Cancer) 01/01/2020 - "Results: A four-gene (epidermal growth factor, mutated in colorectal cancer, mitogen-activated protein kinase kinase 2, and NRAS proto-oncogene, GTPase) signature was built to classify patients into two risk groups using a risk score with different OS in two cohorts (all P < 0.0001). "

Related Drugs and Biologics

1.	Phosphotransferases (Kinase)
2.	MAP Kinase Kinase 1
3.	Mitogen-Activated Protein Kinases
4.	GTP Phosphohydrolases (GTPases)
5.	Ubiquitin-Specific Proteases
6.	Class III Phosphatidylinositol 3-Kinases
7.	Endosomal Sorting Complexes Required for Transport
8.	AMP-Activated Protein Kinases
9.	Type 3 Cyclic Nucleotide Phosphodiesterases
10.	Thioredoxin Reductase 1