Bovine Respiratory Disease Complex

A multifactorial disease of CATTLE resulting from complex interactions between environmental factors, host factors, and pathogens. The environmental factors act as stressors adversely affecting the IMMUNE SYSTEM and other host defenses and enhancing transmission of infecting agents.

Networked: 39 relevant articles (8 outcomes, 7 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Infections
2.	Pneumonic Pasteurellosis (Shipping Fever)
3.	Respiratory Tract Diseases (Respiratory Tract Disease)
4.	Infectious Bovine Rhinotracheitis
5.	Paramyxoviridae Infections (Parainfluenza)

Experts

1.	Church, J S: 4 articles (03/2017 - 12/2007)
2.	Miller, C: 3 articles (03/2017 - 12/2007)
3.	Regev-Shoshani, G: 3 articles (03/2017 - 10/2013)
4.	Dassanayake, Rohana P: 2 articles (01/2018 - 01/2017)
5.	Falkenberg, Shollie M: 2 articles (01/2018 - 01/2017)
6.	Nation, N: 2 articles (03/2017 - 04/2014)
7.	Cook, N J: 2 articles (10/2013 - 12/2007)
8.	Schaefer, A L: 2 articles (10/2013 - 12/2007)
9.	Bello, Nora M: 2 articles (06/2013 - 06/2013)
10.	Nosky, Bruce J: 2 articles (06/2013 - 06/2013)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Bovine Respiratory Disease Complex:

1.	gamithromycinIBA 06/01/2013 - "Field study of the comparative efficacy of gamithromycin and tulathromycin for the treatment of undifferentiated bovine respiratory disease complex in beef feedlot calves." 06/01/2013 - "To compare the efficacy of gamithromycin with that of tulathromycin for control of undifferentiated bovine respiratory disease complex (BRDC) in feedlot calves. " 06/01/2013 - "To compare the efficacy of gamithromycin with that of tulathromycin for the treatment of undifferentiated bovine respiratory disease complex (BRDC) in feedlot calves. " 06/01/2013 - "Field study of the comparative efficacy of gamithromycin and tulathromycin for the control of undifferentiated bovine respiratory disease complex in beef feedlot calves at high risk of developing respiratory tract disease."
2.	tulathromycinIBA 06/01/2013 - "Field study of the comparative efficacy of gamithromycin and tulathromycin for the treatment of undifferentiated bovine respiratory disease complex in beef feedlot calves." 06/01/2013 - "To compare the efficacy of gamithromycin with that of tulathromycin for control of undifferentiated bovine respiratory disease complex (BRDC) in feedlot calves. " 06/01/2013 - "To compare the efficacy of gamithromycin with that of tulathromycin for the treatment of undifferentiated bovine respiratory disease complex (BRDC) in feedlot calves. " 06/01/2013 - "Field study of the comparative efficacy of gamithromycin and tulathromycin for the control of undifferentiated bovine respiratory disease complex in beef feedlot calves at high risk of developing respiratory tract disease."
3.	VaccinesIBA 12/01/2007 - "A review of the biology of bovine herpesvirus type 1 (BHV-1), its role as a cofactor in the bovine respiratory disease complex and development of improved vaccines." 02/01/1994 - "Current modified live and killed BHV-1 vaccines have not reduced the incidence of bovine herpesvirus-1 (BHV-1), the principal viral agent in bovine respiratory disease complex. " 11/01/2019 - "The objective of this study was to examine the impact of a bovine respiratory disease complex (BRDC) vaccine with a temperature-sensitive modified live vaccine (MLV) infectious bovine rhinotracheitis (IBR) component on oestrous cycle parameters and the follicular pool. " 01/01/2015 - "Systematic review and meta-analysis of the effectiveness of commercially available vaccines against bovine herpesvirus, bovine viral diarrhea virus, bovine respiratory syncytial virus, and parainfluenza type 3 virus for mitigation of bovine respiratory disease complex in cattle." 10/01/2000 - "To determine the effect of location for administration of clostridial vaccines on behavior, growth performance, and health of calves at a feedlot, the relative risk of calves developing an injection-site reaction or being misdiagnosed as having bovine respiratory disease complex (BRDC), and the percentage of subcutaneous injection-site reactions that were detectable on carcasses after the hides were removed. "
4.	Theophylline (Theon)FDA LinkGeneric 09/01/1989 - "A field trial was conducted to determine the efficacy of theophylline in relieving respiratory distress associated with bovine respiratory disease complex (shipping fever). "
5.	Anti-Bacterial Agents (Antibiotics)IBA 12/01/2019 - "Vaccination against putative causal organisms is a frequently used and preferred approach to controlling bovine respiratory disease complex (BRD) because it reduces the need for antibiotic use. " 11/01/1974 - "Prophylactic use of antibiotics in preventing bovine respiratory disease complex." 01/01/2020 - "Activation of local innate immune defenses in the upper respiratory tract is one strategy to induce non-specific protection against infection with the diverse array of viral and bacterial pathogens associated with bovine respiratory disease complex (BRDC), while avoiding the use of antibiotics. " 01/01/2015 - "Bovine respiratory disease complex (BRDC) is an important cause of mortality and morbidity in cattle; costing the dairy and beef industries millions of dollars annually, despite the use of vaccines and antibiotics. " 03/01/2017 - "Non-inferiority of nitric oxide releasing intranasal spray compared to sub-therapeutic antibiotics to reduce incidence of undifferentiated fever and bovine respiratory disease complex in low to moderate risk beef cattle arriving at a commercial feedlot."
6.	DNA VaccinesIBA 01/01/2021 - "DNA vaccines are capable of inducing humoral and cellular immunity, and are important to control bovine herpesvirus 1 (BoHV-1), an agent of the bovine respiratory disease complex. " 01/01/2018 - "Our results demonstrate for the first time that the consensus IDV HEF DNA vaccine can elicit complete protection against infection from two lineages of IDV in the guinea pig model.IMPORTANCE Influenza D virus (IDV) infection has been associated with bovine respiratory disease complex, one of the most devastating diseases of the cattle population. "
7.	Sodium IodideIBA 01/01/2018 - "Efficacy of Oral Administration of Sodium Iodide to Prevent Bovine Respiratory Disease Complex."
8.	NK-lysinIBA 01/01/2017 - "Although antimicrobial activity of bovine NK-lysin has been assessed for several bacterial pathogens, not all the important bacterial pathogens that are involved in the bovine respiratory disease complex have been studied. " 01/01/2018 - "Bovine NK-lysin-derived peptides demonstrate antimicrobial activity against various bacterial pathogens, including several involved in bovine respiratory disease complex (BRDC) in cattle; however, such studies are yet to be performed with one important contributor to the BRDC, Mycoplasma bovis. "
9.	ChemokinesIBA 01/01/2019 - "While this study evidenced overexpression of pathogen recognition receptors and chemokines in the lower respiratory tract, IDV-specific IgG1 production as early as 10 days postchallenge, and likely both Th1 and Th2 responses, further studies are warranted to better understand the immune responses triggered by IDV and its role as part of the bovine respiratory disease complex."
10.	Peptides (Polypeptides)IBA 01/01/2018 - "Bovine NK-lysin-derived peptides demonstrate antimicrobial activity against various bacterial pathogens, including several involved in bovine respiratory disease complex (BRDC) in cattle; however, such studies are yet to be performed with one important contributor to the BRDC, Mycoplasma bovis. "

Therapies and Procedures

1.	Resuscitation 04/01/1998 - "Infusion of HSS may be beneficial for initial resuscitation of cattle with naturally developing bovine respiratory disease complex."
2.	Oral Administration 01/01/2018 - "Efficacy of Oral Administration of Sodium Iodide to Prevent Bovine Respiratory Disease Complex."
3.	Subcutaneous Injections 10/01/2000 - "To determine the effect of location for administration of clostridial vaccines on behavior, growth performance, and health of calves at a feedlot, the relative risk of calves developing an injection-site reaction or being misdiagnosed as having bovine respiratory disease complex (BRDC), and the percentage of subcutaneous injection-site reactions that were detectable on carcasses after the hides were removed. "