Mitogen-Activated Protein Kinase 9

A c-jun amino-terminal kinase that is activated by environmental stress and pro-inflammatory cytokines. Several isoforms of the protein with molecular sizes of 48 and 54 KD exist due to multiple ALTERNATIVE SPLICING.

Also Known As:

JNK2 Kinase; JNK2 Stress-Activated Protein Kinase; MAPK9 Mitogen-Activated Protein Kinase; Stress-Activated Protein Kinase JNK2; c-jun Kinase-2; c-jun N-terminal Kinase 2; JNK2 Stress Activated Protein Kinase; Kinase-2, c-jun; MAPK9 Mitogen Activated Protein Kinase; Mitogen Activated Protein Kinase 9; Stress Activated Protein Kinase JNK2; c jun Kinase 2; c jun N terminal Kinase 2

Networked: 30 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Camici, Giovanni G: 2 articles (11/2017 - 11/2008)
2.	Lüscher, Thomas F: 2 articles (11/2017 - 11/2008)
3.	Matter, Christian M: 2 articles (11/2017 - 11/2008)
4.	Osto, Elena: 2 articles (11/2017 - 11/2008)
5.	Van Den Berg, Carla Lynn: 2 articles (05/2015 - 01/2011)
6.	Vesely, David L: 2 articles (07/2012 - 03/2012)
7.	Lemasters, John J: 2 articles (01/2012 - 05/2008)
8.	Theruvath, Tom P: 2 articles (01/2012 - 05/2008)
9.	Zhong, Zhi: 2 articles (01/2012 - 05/2008)
10.	Hahm, Eun-Ryeong: 1 article (03/2022)

Related Diseases

1.	Neoplasms (Cancer) 08/01/2016 - "The results revealed that c-Jun N-terminal kinase 2 (JNK2) was highly expressed in NPC tissues and non-tumor nasopharyngeal epithelium tissues without the 'A-G-G-T' haplotype. " 03/01/2000 - "Inhibition of c-Jun N-terminal kinase 2 expression suppresses growth and induces apoptosis of human tumor cells in a p53-dependent manner." 05/20/2015 - "C-Jun N-terminal kinase 2 (JNK2) is important in mammary tumorigenesis and tumor progression. " 03/30/2022 - "A statistically significant increase in protein level of c-Jun N-terminal kinase 2 was also observed in tumors from DATS-treated rats when compared to controls. " 07/01/2012 - "c-Jun-N-terminal kinase 2. These multiple kinase inhibitors are cytotoxic and cause cell death of cancer cells but not of normal cells."
2.	Breast Neoplasms (Breast Cancer) 05/20/2015 - "c-Jun N-terminal kinase 2 prevents luminal cell commitment in normal mammary glands and tumors by inhibiting p53/Notch1 and breast cancer gene 1 expression." 04/29/2011 - "Here, we show a role for c-Jun N-terminal kinase 2 (JNK2) in promoting mammary cancer cell migration through inhibition of epidermal growth factor substrate 8 (EPS8) expression, a key regulator of EGF receptor (R) signaling and trafficking. " 01/05/2012 - "This study aims to investigate the in vitro effects of Ulinastatin (UTI) and Taxotere (TXT) on cell proliferation; cell apoptosis; xenografted tumor growth; and expression of insulin-like growth factor receptor 1 (IGF-1R), platelet-derived growth factor A (PDGFA), nerve growth factor (NGF), c-Jun N-terminal kinase 2 (JNk-2), and NF-κB in a human primary breast cancer cells and breast cancer cell line MDA-MB-231. "
3.	Pancreatic Neoplasms (Pancreatic Cancer) 01/01/2022 - "c-Jun N-terminal kinase 2 suppresses pancreatic cancer growth and invasion and is opposed by c-Jun N-terminal kinase 1." 11/01/2012 - "TAAs to pancreatic cancer autoantibodies CTDSP1 (carboxy-terminal domain, RNA polymerase II, polypeptide A, small phosphatase 1), MAPK9 (mitogen-activated protein kinase 9), and NR2E3 (nuclear receptor subfamily 2, group E, member 3), which were identified as potentially promising biomarkers in exploratory studies, were evaluated in serum from participants (300 cases, 300 controls) in a population-based case-control pancreatic cancer study in the San Francisco Bay Area. "
4.	Obesity 11/14/2017 - "Inhibition of Vascular c-Jun N-Terminal Kinase 2 Improves Obesity-Induced Endothelial Dysfunction After Roux-en-Y Gastric Bypass." 01/01/2018 - "The c-Jun N-terminal kinase 2 (JNK2) signaling pathway contributes to inflammation and plays a key role in the development of obesity-induced insulin resistance and cardiovascular disease. "
5.	Ischemia 05/27/2008 - "Mitochondrial permeability transition in liver ischemia and reperfusion: role of c-Jun N-terminal kinase 2." 04/01/2001 - "Inhibition of c-Jun N-terminal kinase 1, but not c-Jun N-terminal kinase 2, suppresses apoptosis induced by ischemia/reoxygenation in rat cardiac myocytes."

Related Drugs and Biologics

1.	Cytoplasmic and Nuclear Receptors (Nuclear Receptors)
2.	Peptides (Polypeptides)
3.	Nerve Growth Factor (NGF)
4.	Somatomedin Receptors (Somatomedin Receptor)
5.	Biomarkers (Surrogate Marker)
6.	RNA Polymerase II (RNA Polymerase B)
7.	Phosphoric Monoester Hydrolases (Phosphatases)
8.	Autoantibodies
9.	Docetaxel (Taxotere)
10.	platelet-derived growth factor A

Related Therapies and Procedures

1.	Gastric Bypass (Roux-en-Y Gastric Bypass)
2.	Resuscitation