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Extracellular Signal-Regulated MAP Kinases (Extracellular Signal Regulated Kinases)

A mitogen-activated protein kinase subfamily that is widely expressed and plays a role in regulation of MEIOSIS; MITOSIS; and post mitotic functions in differentiated cells. The extracellular signal regulated MAP kinases are regulated by a broad variety of CELL SURFACE RECEPTORS and can be activated by certain CARCINOGENS.
Also Known As:
Extracellular Signal Regulated Kinases; MAP Kinases, Extracellular Signal Regulated; Extracellular Signal Regulated MAP Kinases; Kinases, Extracellular Signal-Regulated; ERK MAP Kinases; Extracellular Signal-Regulated Kinases; MAP Kinases, Extracellular Signal-Regulated
Networked: 404 relevant articles (6 outcomes, 33 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Giuliani, Daniela: 6 articles (12/2015 - 07/2010)
2. Guarini, Salvatore: 6 articles (12/2015 - 07/2010)
3. Ottani, Alessandra: 6 articles (12/2015 - 07/2010)
4. Berrocoso, Esther: 3 articles (07/2015 - 06/2014)
5. Zhang, Jun: 3 articles (05/2015 - 12/2007)
6. Galantucci, Maria: 3 articles (09/2013 - 07/2010)
7. Komuro, Issei: 3 articles (03/2012 - 06/2004)
8. Spaccapelo, Luca: 3 articles (03/2012 - 07/2010)
9. Akazawa, Hiroshi: 3 articles (03/2012 - 06/2004)
10. Gereau, Robert W: 3 articles (09/2011 - 09/2004)

Related Diseases

1. Ischemia
2. Neoplasms (Cancer)
3. Fibrosis (Cirrhosis)
4. Hypertension (High Blood Pressure)
5. B-Cell Lymphoma (Lymphoma, B Cell)
01/01/2012 - "This protective effect is mediated by neuronal TNF-α and activation of the extracellular signal-regulated kinases 1 and 2 pathway via phosphorylation and inactivation of the B-cell lymphoma 2-associated death promoter protein. "
11/01/2015 - "The phosphorylated c-Jun-N-terminal kinase (p-JNK), phosphorylated extracellular signal-regulated kinases 1/2 (p-ERK1/2), B-cell lymphoma 2 (Bcl-2), Bcl-2-associated X protein (Bax) and caspase-3 were assayed by western blot. "
01/01/2013 - "Various molecular signals, such as B-cell lymphoma (Bcl)-2, Bcl-2-associated death promoter, Bcl-x, caspase-3, cleaved caspase-3, Fas, signal transducer and activator of transcription 5, extracellular signal-regulated kinases, MMP-9 and pan-janus kinase/stress-activated protein kinase 1, indicated that apoptosis, inhibition of growth and invasion was cleared on sorafenib-eluting PCL films. "
04/12/2011 - "On the other hand, propofol could up-regulate the expression of key proteins involved in neuroprotection including B-cell lymphoma 2 at a dose range of 1-10 μM, activation of phospho-serine/threonine protein kinase at a dose range of 0.5-10 μM, and activation of phospho-extracellular signal-regulated kinases at a dose range of 5-10 μM. "
07/01/2013 - "Pharmacological modulation of survivin was tagged with its evolving functional complexity associated with various cell-signaling cascades including PI3K/AKT, mammalian target of rapamycin (mTOR), extracellular signal-regulated kinases (ERK), mitogen-activated protein kinases (MAPK), signal transducer and activator of transcription (STAT), hypoxia-inducible factor-1α (HIF-1α), heat-shock protein 90 (HSP90), p53, B-cell lymphoma 2 (Bcl2), epidermal growth factor receptor (EGFR), vascular endothelial growth factor (VEGF) etc. The present review provides a multifaceted role of survivin and its mechanistic action in an array of clinical cancers. "

Related Drugs and Biologics

1. Phosphotransferases (Kinase)
2. Protein Kinases (Protein Kinase)
3. Sirolimus (Rapamycin)
4. Brain-Derived Neurotrophic Factor (BDNF)
5. sorafenib (BAY 43-9006)
6. Caspase 3 (Caspase-3)
7. Cyclooxygenase 2 (Cyclooxygenase-2)
8. Mitogen-Activated Protein Kinase 8
9. STAT5 Transcription Factor
10. Minocycline (Cyclops)

Related Therapies and Procedures

1. Ligation
2. Analgesia
3. Cell Transplantation
4. Electroacupuncture
5. Heterologous Transplantation (Xenotransplantation)