TNF Receptor-Associated Factor 6 (TRAF6)

A signal transducing tumor necrosis factor receptor associated factor that is involved in regulation of NF-KAPPA B signalling and activation of JNK MITOGEN-ACTIVATED PROTEIN KINASES.

Also Known As:

Networked: 947 relevant articles (42 outcomes, 146 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Choi, Yongwon: 11 articles (01/2018 - 07/2002)
2.	Wang, Jing: 7 articles (02/2022 - 01/2017)
3.	Fang, Jing: 7 articles (01/2022 - 07/2012)
4.	Starczynowski, Daniel T: 7 articles (01/2022 - 01/2010)
5.	Kumar, Ashok: 7 articles (12/2017 - 12/2010)
6.	Kobayashi, Takashi: 6 articles (12/2022 - 07/2002)
7.	Chen, Xiang: 6 articles (06/2022 - 02/2016)
8.	Zhang, Yan: 6 articles (01/2022 - 01/2019)
9.	Heldin, Carl-Henrik: 6 articles (03/2021 - 02/2009)
10.	Yang, Guang: 6 articles (02/2021 - 04/2013)

Related Diseases

1.	Inflammation (Inflammations) 10/01/2023 - "Collectively, inhibition of TRAF6 improved HTG-AP and the associated inflammation by alleviating pyroptosis." 05/01/2022 - "Overexpression of miR-146a-5p ameliorates inflammation and autophagy in TLCs-treated AR42J cells by inhibiting IRAK1/ TRAF6/NF-κB pathway." 01/01/2021 - "Importantly, preclinical administration of miR-146a mimic, or small molecule inhibition of the miR-146a targets, TRAF6 and RIPK2, ameliorates colonic inflammation and CRC. " 02/05/2017 - "MicroRNA-146a Ameliorates Inflammation via TRAF6/NF-κB Pathway in Intervertebral Disc Cells." 09/01/2020 - "Taken together, our study revealed that MD-2 deficiency ameliorated renal I/R-induced inflammation and oxidative stress via inhibition of TLR4/TRAF6/NF-κB pathway."
2.	Reperfusion Injury 01/01/2023 - "Correction: miR-146a Ameliorates Liver Ischemia/Reperfusion Injury by Suppressing IRAK1 and TRAF6." 01/01/2022 - "FAM49B, restrained by miR-22, relieved hepatic ischemia/reperfusion injury by inhibiting TRAF6/IKK signaling pathway in a Rac1-dependent manner." 01/01/2014 - "miR-146a ameliorates liver ischemia/reperfusion injury by suppressing IRAK1 and TRAF6." 10/20/2022 - "Exosomal transfer of microRNA-590-3p between renal tubular epithelial cells after renal ischemia-reperfusion injury regulates autophagy by targeting TRAF6." 01/01/2020 - "Additionally, the liver inflammatory response and tissue damage were ameliorated in mice overexpressing OTUD4.Taken together, these results show that OTUD4 can negatively regulate NF-κB activation by suppressing the K63-linked ubiquitination of TRAF6, thus alleviating hepatic ischemia-reperfusion injury."
3.	Infections 10/24/2023 - "To elucidate its role in defense against Edwardsiella tarda infection in teleost fish, TRAF6 homologue was identified from obscure puffer (Takifugu obscurus) and functionally analyzed in this study. " 10/01/2022 - "In this study, we found that the expression levels of IRAK4, TRAF6, TAK1, and RELA/p65 were obviously reduced late in NDV infection. " 04/01/2019 - "In the present study, we identified and characterized the homologues of MyD88 and TRAF6 in Qihe crucian carp Carassius auratus, termed as CaMyD88 and CaTRAF6, respectively, and examined their roles during pathogenic infection. " 12/01/2017 - "The study has been designed to assess the correlation of TLR3, MAVS, TRIF, and TRAF6 outcome of HCV infection. " 04/01/2017 - "Detailed studies revealed that HCV infection activates MAVS that in turn recruits TRAF6 via TRAF-interacting-motifs (TIMs), and TRAF6 subsequently directly recruits GP73 to MAVS via coiled-coil domain. "
4.	Neoplasms (Cancer) 06/01/2019 - "These investigations suggest that the RING domain of TRAF6 could serve as a de novo biological target for therapeutic treatment in cancers." 01/01/2023 - "PHB1 and TRAF6 knockdown eliminated tumor cells from the circulation in vivo. " 01/01/2021 - "In this study, we found that the expression of TRAF6 in MDSCs derived from tumor tissue was significantly upregulated compared with that of MDSCs from spleen of tumor-bearing mice. " 10/15/2019 - "Animal studies were performed to investigate the effects of TRAF6 on tumor growth. " 06/01/2019 - "In this study, we aimed to investigate the biological function of TRAF6 and its underlying molecular mechanisms in cancer. "
5.	Melanoma (Melanoma, Malignant) 08/01/2023 - "In this study, we found that knockdown of TRAF6 induced both apoptosis and autophagy in melanoma cells. " 11/01/2020 - "In this study, we found that TRAF6 was significantly upregulated in CAFs adjacent to melanoma cells. " 11/01/2020 - "A previous study demonstrated that TRAF6 promotes the malignant phenotype of melanoma cells. " 02/09/2016 - "Although studies have shown that TRAF6 has oncogenic activity, the role of TRAF6 in melanoma is unclear. " 08/01/2023 - "These findings highlight the pivotal role of TRAF6 in regulating autophagy and apoptosis in melanoma, emphasizing its significance as a novel therapeutic target for melanoma treatment."

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Interleukin-6 (Interleukin 6)
3.	Tumor Necrosis Factor Receptors (Tumor Necrosis Factor Receptor)
4.	NF-kappa B (NF-kB)
5.	Phosphotransferases (Kinase)
6.	Lipopolysaccharides
7.	TNF Receptor-Associated Factor 4
8.	Docosahexaenoic Acids
9.	Antiphospholipid Antibodies
10.	iguratimod

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Ligation
3.	Therapeutics
4.	Mesenchymal Stem Cell Transplantation
5.	Punctures