Pituitary ACTH Hypersecretion

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209 relevant articles (26 outcomes, 17 trials/studies) found for this Disease

Description: A disease of the PITUITARY GLAND characterized by the excess amount of ADRENOCORTICOTROPIC HORMONE secreted. This leads to hypersecretion of cortisol (HYDROCORTISONE) by the ADRENAL GLANDS resulting in CUSHING SYNDROME.

Also Known As:

Adrenocorticotropic Hormone, Inappropriate Secretion; ACTH Hypersecretion, Pituitary; Disease, Cushing; Hypersecretion, Pituitary ACTH; Cushing Disease; Inappropriate ACTH Secretion Syndrome; Inappropriate Adrenocorticotropic Hormone Secretion

Relationship Network

Disease Context: Research Results

Nervous System Diseases: 3406

Central Nervous System Diseases: 929

Brain Diseases: 1117

Hypothalamic Diseases: 27

Pituitary Diseases: 323

Hyperpituitarism: 13

Pituitary ACTH Hypersecretion: 209

Endocrine System Diseases: 390

Pituitary Diseases: 323

Hyperpituitarism: 13

Pituitary ACTH Hypersecretion: 209

Related Diseases

1.	Cushing Syndrome
2.	Syndrome
3.	Neoplasms (Cancer)
4.	Pituitary Neoplasms (Pituitary Adenoma)
5.	Acromegaly
48 Diseases and 83 more articles analyzed in the Full Patient-Physician Summary Report, order at left...

Experts

1.	Batista, Dalia: 2 articles (10/2006 - 09/2005)
2.	Shah, Nalini: 1 article (05/2008)
3.	Menon, Padma: 1 article (05/2008)
4.	Gopal, Raju: 1 article (05/2008)
5.	Bandgar, Tushar: 1 article (05/2008)
6.	Su, Chang-bao: 1 article (04/2008)
7.	Wang, Ren-zhi: 1 article (04/2008)
8.	Li, Yong-ning: 1 article (04/2008)
9.	Ma, Wen-bin: 1 article (04/2008)
10.	Xing, Bing: 1 article (04/2008)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Pituitary ACTH Hypersecretion:

1.	Adrenocorticotropic Hormone (ACTH)FDA Link 01/01/2005 - "Postoperatively, her serum ACTH concentration dropped below 5 pg/ml. In this case, inferior petrosal sinus sampling was extremely helpful for the diagnosis of Cushing disease, and operations were able to be performed safely using the neuronavigation system in drilling of the incompletely pneumatized sphenoid sinus." 09/01/1993 - "The CS/peripheral (CS/P) ratio of ACTH (mean = 66.1) was significantly greater than the IPS/peripheral (IPS/P) ratio (mean = 14.9) in Cushing disease" 05/01/1976 - "It was shown that examination of blood ACTH and cortizol content could be used as an auxiliary criterion in the diagnosis of Itsenko-Cushing disease, in ascertaining the severity of this disease and in the assessment of the efficacy of the treatment carried out." 01/01/2008 - "BACKGROUND AND PURPOSE: Selective venous sampling from the posterior portion of the cavernous sinus (CS) is recommended for the diagnosis of Cushing disease, because samples from the posterior portion yield higher adrenocorticotropic hormone (ACTH) levels than those from the anterior and middle portions" 01/01/2006 - "Cushing disease, which is caused by the excessive production of ACTH, is a rare and complex endocrine disorder that still represents a major challenge for the physician in terms of accurate diagnosis and efficient treatment" Get all the results and reference details, order at left...
2.	Hydrocortisone (Cortisol)FDA LinkGeneric 01/01/2004 - "Remission (normalization of 24-hour urine-free cortisol (UFC) and its metabolites) was achieved in one patient with Cushing disease" 11/01/2003 - "Remission (normalization of 24-hour urine-free cortisol (UFC) and its metabolites) was achieved in one patient with the Cushing disease" 01/01/2007 - "Cushing disease: use of perioperative serum cortisol measurements in early determination of success following pituitary surgery." 03/01/2002 - "Several findings have also shown an inverse relation between hippocampal volume and cortisol levels in psychiatric populations including patients who are depressed and patients with Cushing disease" 07/01/2001 - "Serum cortisol response to transsphenoidal surgery for Cushing disease." Get all the results and reference details, order at left...
3.	Dexamethasone (Maxidex)FDA LinkGeneric 11/01/1988 - "Stages of body responses to small doses of dexamethasone (the stage of lost responses, the stage of incomplete loss and the stage of recovered responses) were identified contributing to objective assessment of the gravity, course, presence, recurrence and remission of Itsenko-Cushing disease." 05/01/2003 - "Transsphenoidal microsurgical treatment of Cushing disease: postoperative assessment of surgical efficacy by application of an overnight low-dose dexamethasone suppression test." 07/20/1995 - "We made a diagnosis of Cushing disease with dexamethasone suppression test, CRF stimulation test, venous sampling, and MRI scan" 11/01/1988 - "Use of the "extended" minor dexamethasone test in Itsenko-Cushing disease]" 10/01/1996 - "METHODS: Seventeen consecutive patients with hypercortisolism and with high-dose dexamethasone suppression test results suggesting Cushing disease underwent bilateral cavenous sinus sampling with CRH stimulation" Get all the results and reference details, order at left...
4.	Protons (Proton)IBA 08/01/1987 - "Thus the results of proton beam therapy of 98 patients with Icenko-Cushing disease after a follow-up of 3-5 years showed a high efficacy of this type of treatment" 01/01/1990 - "The efficacy of proton irradiation of the hypophysis in children with Itsenko-Cushing disease]" 01/01/1991 - "The effect of proton therapy on the protein-amino acid metabolism in Itsenko-Cushing disease]" 01/01/1990 - "The authors represent the results of the treatment of 20 children with Itsenko-Cushing disease (ICD) by proton-beam irradiation of the pituitary body" 09/01/1989 - "Adenohypophysis function in Itsenko-Cushing disease before and after proton-beam irradiation]" Get all the results and reference details, order at left...
5.	HormonesIBA 06/01/2005 - "Endocrinological remission occurred in 57% of patients undergoing RTSS to treat hormone hypersecretion; most of these patients had Cushing disease" 07/01/1966 - "A study of the biosynthesis of steroid hormones in vitro in the adrenal cortex in Itsenko-Cushing disease]" 07/01/1985 - "Steroid hormone level in patients with Itsenko-Cushing disease]" 11/01/1983 - "Dynamics of secretion of hypothalamo-hypophyseal system hormones in Itsenko-Cushing disease as affected by combination therapy]" 01/01/1989 - "Hypophyseal and adrenal hormones and the immune reactivity of patients with Itsenko-Cushing disease after an adrenal autograft]" Get all the results and reference details, order at left...
6.	ProlactinIBA 02/01/2003 - "At a median follow-up period of 16 months (range 3-45 months), surgical remission rates were as follows: in 40 patients with endocrine-inactive macroadenomas, 95% for noninvasive and 40% for invasive tumors; in the 20 patients with prolactinomas, 75% for prolactinomas with an initial prolactin (PRL) level lower than 200 ng/ml, 33% for those with a PRL level between 200 and 600 ng/ml, and 0% for those with a PRL level higher than 1400 ng/ml; in the 15 patients with Cushing disease, 73% for microadenomas and 25% for macroadenomas; in the 10 patients with acromegaly, 75% for microadenomas and 50% for macroadenomas; in the five patients with Rathke cleft cysts, 80%; and in the five patients with craniopharyngiomas, 40%" 05/24/1976 - "A total of 349 patients with pituitary tumors, including acromegaly, Cushing disease, Nelson syndrome, prolactin-secreting adenoma, and chromophobe adenoma, have been treated with heavy-particle radiation during the past 17 years" 03/01/1991 - "The gonadotropin, prolactin and sex steroid content of the blood from the inferior cavernous sinuses and the adrenal and ovarian veins of women with Itsenko-Cushing disease]" 07/01/1984 - "Interrelation of disorders in gonadotropin and prolactin secretion and the activity of the hypothalamo-hypophyseal-adrenal system in Itsenko-Cushing disease]" 03/01/1991 - "Results are reported of a study of the content of gonadotropins, prolactin and sex steroids in different regions of the vascular bed in women with Itsenko-Cushing disease" Get all the results and reference details, order at left...
7.	Cyproheptadine (Periactin)FDA Link 03/01/1983 - "Potential use of the antiserotonin preparation cyproheptadine (peritol) in Itsenko-Cushing disease]" 05/01/1977 - "Treatment of Cushing disease in Childhood with cyproheptadine." 06/01/1984 - "Prolonged remission of Cushing disease after treatment with cyproheptadine." 01/01/1985 - "The study showed a different sensitivity of patients with Icenko-Cushing disease to peritol and parlodel" 10/01/1983 - "Function of the hypophysis in patients with Itsenko-Cushing disease treated with peritol and chloditan]" Get all the results and reference details, order at left...
8.	Bromocriptine (Parlodel)FDA LinkGeneric 06/01/1978 - "Clinical and biochemical remission of Itsenko-Cushing disease during parlodel treatment]" 01/01/1985 - "The study showed a different sensitivity of patients with Icenko-Cushing disease to peritol and parlodel" 01/01/1991 - "A patient suffering Cushing disease is presented in whom the administration of ciproheptadine, bromocriptine and sodium valproate in a single dose did not manage to control the clinical-biologic manifestations of the process" 09/01/1988 - "The results of investigation of the secretion of hypophyseal, adrenal and renal hormones resulting from parlodel administration in 44 patients with Itsenko-Cushing disease were discussed" 09/01/1988 - "Effect of a single dose of parlodel on the secretion of various hormones in Itsenko-Cushing disease]" Get all the results and reference details, order at left...
9.	cabergoline FDA LinkGeneric 05/01/2008 - "Remission in Cushing disease with cabergoline." 01/01/2006 - "In the present article, we examine recent studies that have investigated the therapeutic potential of new generations of drugs for the treatment of Cushing disease such as cabergoline and SOM230" Get all the results and reference details, order at left...
10.	alpha-Tocopherol FDA Link 07/01/1988 - "In Itsenko-Cushing disease an elevated level of lipid peroxidation products in plasma, erythrocytes, liver, muscular tissue, and a decrease in the level of alpha-tocopherol in erythrocytes against a background of its elevation in plasma were detected" 07/01/1988 - "In patients with Itsenko-Cushing disease a study was made of the content of lipid hydroperoxides, malonic dialdehyde, alpha-tocopherol in plasma and erythrocytes (in 31 untreated patients, in 41 patients with recurrences, in 61 patients during clinical remission and in 14 patients after bilateral adrenalectomy), in tissue biopsy specimens: of the liver (13), muscles (23), fatty tissue (30)" Get all the results and reference details, order at left...
96 Drugs and Important Bio-Agents and 173 more articles analyzed in the Full Patient-Physician Summary Report, order at left...

Therapies and Procedures

1.	Adrenalectomy 02/01/1989 - "Data are reported of the functional state of the hypothalamoadrenal system in 119 women with Itsenko-Cushing disease in the active stage, stage of stable clinical remission and after total adrenalectomy" 01/01/2008 - "CONCLUSIONS: Pituitary MRI study of patients with Cushing disease treated by adrenalectomy remains difficult" 06/22/1955 - "Cushing disease: clinical and biochemical study, effects of bilateral subtotal adrenalectomy.]" 04/15/2008 - "Effects of adrenalectomy on the treatment of Cushing disease]" 01/01/2007 - "Despite undergoing multiple treatment modalities, some patients may ultimately require bilateral adrenalectomy for definitive treatment to eliminate hypercortisolemia associated with Cushing disease" Get all the results and reference details, order at left...
2.	Aftercare (After-Treatment) 01/01/1992 - "Remission of Itsenko-Cushing disease after treatment with nizoral]" 06/01/1984 - "Prolonged remission of Cushing disease after treatment with cyproheptadine." 03/01/2002 - "A 49-year-old man, diagnosed as having Cushing disease in 1976 at the age of 26, underwent a Hardy operation 13 years after treatment with reserpine combined with pituitary radiation" 08/01/1982 - "State of the skin in Itsenko-Cushing disease and hormonally active tumors of the adrenal cortex before and after treatment with chloditan]" Get all the results and reference details, order at left...
3.	Hormone Replacement Therapy (Therapy, Hormone Replacement) 01/01/2007 - "OBJECT: Transsphenoidal pituitary surgery is the primary therapy for Cushing disease because of its potential to produce lasting remission without the need for long-term drug or hormone replacement therapy" Get all the results and reference details, order at left...
4.	Combined Modality Therapy 01/01/2007 - "Some patients, however, will not achieve sustained remission after transsphenoidal surgery and can exhibit persistent or recurrent Cushing disease that requires multimodal treatment to achieve remission" Get all the results and reference details, order at left...
5.	Hypophysectomy 06/01/2005 - "Postoperative endocrinological deficiencies were uncommon unless planned total hypophysectomy was performed to treat Cushing disease" 09/15/1988 - "We report cumulative results of the transsphenoidal microsurgical treatment of Cushing disease in 221 patients: 173 patients had selective adenomectomy, 25 had total hypophysectomy, 6 had partial hypophysectomy, and 12 had exploration only" 01/01/1991 - "The composition and blood concentration of free aminoacids and other aminocompounds were investigated using automatic aminoacid analysis by a physiological program in 12 patients with diagnosed corticotropin secreting hypophyseal disease (Itsenko-Cushing disease) before and 1-3 years after proton "hypophysectomy"" Get all the results and reference details, order at left...
11 Therapies and Procedures and 52 more articles analyzed in the Full Patient-Physician Summary Report, order at left...

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on Pituitary ACTH Hypersecretion

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