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Myofibroma

A benign tumor that consists chiefly of fibrous CONNECTIVE TISSUE, with variable numbers of MUSCLE CELLS forming portions of the neoplasm (From Stedman's, 27th ed).
Also Known As:
Myofibromas
Networked: 54 relevant articles (1 outcomes, 5 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Myofibromatosis
2. Myopericytoma
3. Angiomyoma (Angioleiomyoma)
4. Myxoma (Myxomas)
5. Neoplasms (Cancer)

Experts

1. Dachy, Guillaume: 5 articles (04/2021 - 01/2017)
2. Demoulin, Jean-Baptiste: 5 articles (04/2021 - 01/2017)
3. Bly, Randall A: 2 articles (02/2022 - 01/2020)
4. Dahl, John P: 2 articles (02/2022 - 01/2020)
5. Perkins, Jonathan A: 2 articles (02/2022 - 01/2020)
6. Wenger, Tara L: 2 articles (02/2022 - 01/2020)
7. Wu, Natalie: 2 articles (02/2022 - 01/2020)
8. Boulouadnine, Boutaina: 2 articles (04/2021 - 01/2021)
9. Fraitag, Sylvie: 2 articles (01/2021 - 08/2019)
10. Arts, Florence A: 2 articles (08/2019 - 01/2017)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Myofibroma:
1. VimentinIBA
2. Platelet-Derived Growth Factor beta Receptor (Receptor, Platelet Derived Growth Factor beta)IBA
3. Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA
4. RNA (Ribonucleic Acid)IBA
5. Platelet-Derived Growth Factor Receptors (Platelet-Derived Growth Factor Receptor)IBA
6. trichrome stainIBA
7. DesminIBA
05/01/2012 - "Solitary and multifocal myofibromas stained positively for smooth muscle actin (SMA) in 95% and 92% of cases, muscle-specific actin (MSA) in 75% and 50% of cases, and desmin in 10% and 14% of cases, respectively. "
05/01/1998 - "These lesions include: fibromatoses in adults and infants (infantile digital fibromatosis and infantile myofibromatosis); myofibroma of adults, an almost exclusively solitary lesion in the skin which is characterized morphologically as a biphasic lesion composed of spindle-shaped eosinophilic tumour cells and more primitive mesenchymal tumour cells associated with a haemangiopericytoma-like vasculature; dermatomyofibroma (plaque-like dermal fibromatosis), a band-like myofibroblastic proliferation in young female patients, which is mainly located in the periaxillar region and in which distinction from more aggressive, plaque-like variant of dermatofibrosarcoma protuberans is mandatory; myofibroblastoma of the breast, a well-circumscribed lesion composed of spindle shaped, desmin-positive tumour cells, which is seen mainly in elderly male patients and has to be distinguished from other spindle cell lesions of the breast; angiomyofibroblastoma, a well-circumscribed myofibroblastic neoplasm of the vulva and vagina composed of avoid to round myoid tumour cells with scattered multinucleated cells, which forms a continuous morphological spectrum with the clinically more aggressive angiomyxoma in this location; intranodal myofibroblastoma, a distinctive proliferation of myofibroblastic cells associated with so-called amianthoid fibres, which is seen most commonly in inguinal lymph nodes; myofibroblastoma/myofibroblastic tumour of soft tissues, a variably well-circumscribed myofibroblastic lesion which lacks atypia and is composed of actin and/or desmin positive tumour cells, and poorly delineated sarcomas with myofibroblastic differentiation (myofibrosarcoma)."
01/01/2006 - "Despite overlapping morphologic features to angioleiomyoma and myofibroma, myopericytoma represents a distinct perivascular, myoid neoplasm of skin and soft tissues, characterized by a broad morphologic spectrum of concentrically, perivascularly growing myoid tumor cells that stain positively for ASMA and often for h-caldesmon, whereas desmin is usually negative. "
01/01/2019 - "Using a tissue microarray technique (TMA), cases of myofibroma (MF), of nodular fasciitis (NF), of desmoplastic fibroma (DF), and of myofibroblastic sarcoma (MS) from the Universidad Autónoma Metropolitana Xochimilco, and a Private Oral Pathology Service in Mexico City were stained with antibodies against alpha-smooth muscle actin (α-SMA), H-caldesmon, vimentin, desmin, β-catenin, CD34, anaplastic lymphoma protein kinase (ALK-1), and Ki-67. "
8. Calmodulin-Binding Proteins (Caldesmon)IBA
9. CateninsIBA
10. beta CateninIBA

Therapies and Procedures

1. Therapeutics
2. Oral Pathology
3. Hysterectomy
4. Pancreaticoduodenectomy
5. Tracheotomy