Estrogen Receptor beta

One of the ESTROGEN RECEPTORS that has greater affinity for ISOFLAVONES than ESTROGEN RECEPTOR ALPHA does. There is great sequence homology with ER alpha in the DNA-binding domain but not in the ligand binding and hinge domains.

Also Known As:

Networked: 1271 relevant articles (22 outcomes, 209 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Gustafsson, Jan-Ake: 58 articles (02/2014 - 01/2002)
2.	Warner, Margaret: 20 articles (01/2018 - 06/2002)
3.	Gustafsson, J A: 15 articles (12/2008 - 02/2000)
4.	Sasano, Hironobu: 13 articles (01/2017 - 03/2004)
5.	Dahlman-Wright, Karin: 12 articles (01/2014 - 06/2003)
6.	Gustafsson, Jan-Åke: 11 articles (11/2020 - 03/2011)
7.	Korach, Kenneth S: 11 articles (01/2018 - 10/2003)
8.	Ho, Shuk-Mei: 11 articles (08/2013 - 10/2003)
9.	Suzuki, Takashi: 10 articles (05/2013 - 03/2004)
10.	Younes, Mamoun: 9 articles (12/2018 - 05/2002)

Related Diseases

1.	Neoplasms (Cancer) 09/25/2020 - "Here, we found that a combined treatment of estrogen receptor beta (ERβ) agonist and PD-1 antibody treatment improved therapeutic efficacy in mouse tumor models, compared with monotherapies, by reducing infiltration of myeloid-derived suppressor cells (MDSCs) and increasing CD8+ T cells in tumors. " 05/01/2017 - "Human testis, gonocytes, and adult germ cells mainly express estrogen receptor beta, and estrogen receptor beta loss is associated with advanced tumor stage; however, the molecular mechanisms of estrogen receptor beta-protective effects are still to be defined. " 10/09/2018 - "Estrogen receptor beta (ERβ), a well-characterized tumor suppressor, is expressed in 30% of TNBCs, and its expression is associated with improved patient outcomes. " 06/28/2022 - "Recent studies demonstrated estrogen receptor beta (ERβ) exerts tumor suppressor functions in OCa. " 01/01/2019 - "Recent studies suggest that estrogen receptor beta (ERβ), may function as a tumor suppressor in GBM. "
2.	Breast Neoplasms (Breast Cancer) 01/01/2014 - "This study is to determine the expression of estrogen receptor beta (ERβ) in breast cancer patients and to evaluate its relationship with clinicopathological parameters of breast cancer and its effects on the prognosis of breast cancer patients. " 06/15/2010 - "In this study, we applied the ChIP-on-chip approach to identify ERbeta-binding sites on a genome-wide scale, identifying 1,457 high-confidence binding sites in ERbeta-overexpressing MCF7 breast cancer cells. " 02/01/2010 - "Estrogen receptor-beta expression in invasive breast cancer in relation to molecular phenotype: results from the Nurses' Health Study." 01/01/2009 - "Despite many published studies on ERbeta, progress towards understanding its role in breast cancer remains slow. " 02/01/2008 - "This study aimed to define the relationship between ERbeta and clinicopathological parameters in a mixed cohort of breast cancer and, furthermore, to investigate the impact of ERbeta expression on disease outcome. "
3.	Carcinogenesis 01/01/2012 - "Previous studies have shown that Estrogen-receptor beta (ERβ) levels decreased along with ovarian carcinogenesis. " 02/01/2009 - "Many studies indicate that ERbeta is down regulated during carcinogenesis. " 07/15/2008 - "The first aim of this study was to investigate the consequence of ERbeta deficiency on intestinal tumorigenesis in the Apc(Min/+) mouse model. " 02/01/2008 - "Studies indicate that estrogen receptor beta, encoded by the ESR2 gene on chromosome 14q, may play a role in ovarian carcinogenesis. " 07/03/2017 - "Somatic loss of estrogen receptor beta and p53 synergize to induce breast tumorigenesis."
4.	Inflammation (Inflammations) 01/01/2019 - "Estrogen receptor beta (ERβ) expression was decreased by TNF-α-induced inflammation and restored by E2 treatment. " 01/01/2017 - "Inhibitory effect of estrogen receptor beta on P2X3 receptors during inflammation in rats." 01/01/2010 - "As seen in the AA model, the selective ERbeta agonist ERB-79 did not suppress inflammation. " 07/01/2008 - "In these modeling systems of airway inflammation, an ERbeta agonist was ineffective. " 01/01/2008 - "In fact, selective ERbeta agonists have beneficial effects in preclinical models involving inflammation without causing growth-promoting effects on the uterus or mammary gland. "
5.	Ovarian Neoplasms (Ovarian Cancer) 08/15/2004 - "This study shows that ERbeta is an important regulator of proliferation and motility of ovarian cancer and provides the first evidence for a proapoptotic role of ERbeta. " 06/28/2022 - "Therapeutic Targeting of Ovarian Cancer Stem Cells Using Estrogen Receptor Beta Agonist." 07/25/2017 - "Therapeutic utility of natural estrogen receptor beta agonists on ovarian cancer." 09/01/2011 - "Cytoplasmic expression of estrogen receptor beta (ERβ) predicts poor clinical outcome in advanced serous ovarian cancer." 01/01/2009 - "The ERbeta promoter is differentially methylated in ovarian cancer cells. "

Related Drugs and Biologics

1.	Estrogens (Estrogen)
2.	Estrogen Receptor alpha
3.	Estrogen Receptor beta
4.	Estrogen Receptors
5.	Testosterone (Sustanon)
6.	Messenger RNA (mRNA)
7.	Proteins (Proteins, Gene)
8.	Protein Isoforms (Isoforms)
9.	Gonadal Steroid Hormones (Sex Hormones)
10.	Estradiol (Delestrogen)

Related Therapies and Procedures

1.	Therapeutics
2.	Immunotherapy
3.	Drug Therapy (Chemotherapy)
4.	Ovariectomy (Oophorectomy)
5.	Lasers (Laser)