PPAR gamma

A nuclear transcription factor. Heterodimerization with RETINOID X RECEPTOR ALPHA is important in regulation of GLUCOSE metabolism and CELL GROWTH PROCESSES. It is a target of THIAZOLIDINEDIONES for control of DIABETES MELLITUS.

Also Known As:

Networked: 4960 relevant articles (301 outcomes, 811 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Kadowaki, Takashi: 30 articles (02/2010 - 01/2002)
2.	Nakajima, Atsushi: 24 articles (01/2010 - 07/2002)
3.	Safe, Stephen: 23 articles (06/2010 - 03/2003)
4.	Wada, Koichiro: 22 articles (02/2010 - 07/2002)
5.	Auwerx, Johan: 21 articles (01/2019 - 01/2002)
6.	Thiemermann, Christoph: 21 articles (08/2010 - 05/2002)
7.	Staels, Bart: 20 articles (06/2008 - 05/2002)
8.	Gonzalez, Frank J: 19 articles (01/2017 - 05/2002)
9.	Phipps, Richard P: 18 articles (01/2013 - 01/2002)
10.	Heneka, Michael T: 18 articles (01/2012 - 06/2002)

Related Diseases

1.	Insulin Resistance 01/01/2022 - "Peroxisome proliferator-activated receptor gamma (PPARγ) agonists are highly effective in treating insulin resistance. " 07/15/2004 - "Recent data have shown that peroxisome proliferator-activated receptor-gamma agonists may exert protective effects on the vascular endothelium by amelioration of insulin resistance and through direct anti-inflammatory effects. " 07/22/2010 - "All these findings strongly suggest that Cdk5-mediated phosphorylation of PPARgamma may be involved in the pathogenesis of insulin-resistance, and present an opportunity for development of an improved generation of anti-diabetic drugs through PPARgamma." 09/01/2009 - "Insulin sensitivity improved in the group receiving PPARgamma agonist (P = 0.03). " 06/15/2009 - "They acted as full or partial PPARgamma agonist, or improved insulin resistance through non-PPARgamma pathway."
2.	Type 2 Diabetes Mellitus (MODY) 01/01/2009 - "Although PPARgamma activation by TZDs is in general considered beneficial for the amelioration of diabetic renal complications in Type 2 diabetes, the underlying mechanism(s) remains only partially characterized. " 03/27/1997 - "Activation of the RXR:PPARgamma dimer with rexinoids may provide a new and effective treatment for NIDDM." 05/01/2010 - "The Pro12Ala polymorphism in the PPAR-gamma gene has been associated with reduced incidence of type 2 diabetes. " 01/01/2023 - "Over the past decade, there has been a significant increase in studies investigating the relationship between the polymorphisms of the Peroxisome Proliferator-Activated Receptor gamma (PPARγ) gene and Type 2 Diabetes (T2D). " 01/01/2015 - "Further studies are needed for the transformation of PPAR gamma gene in plants and evaluate in animals for the treatment of type 2 diabetes. "
3.	Inflammation (Inflammations) 12/01/2004 - "Although PPARgamma expression is generally low in the CNS, induction of PPARgamma expression during inflammation could be beneficial for inducing Abeta clearance. " 01/15/2000 - "Our data suggest that compounds capable of activating PPARgamma in leukocytes will not be useful for the treatment of acute inflammation." 06/01/2005 - "Agonists of the peroxisome proliferator-activated receptor-gamma may help to regulate inflammation by modulating the production of inflammatory mediators and adhesion molecules. " 04/02/2001 - "A role for the RXR/PPARgamma heterodimer in the protection against colon inflammation was explored by the use of selective RXR and PPARgamma agonists. " 10/19/2023 - "This study investigates the effects of peroxisome proliferator-activated receptor gamma (PPARγ) inhibition on bone and immune cell profile in aged female mice, as well as in vitro stromal stem cell (SSC) osteogenic differentiation and inflammation gene expression. "
4.	Neoplasms (Cancer) 10/01/2012 - "Recent studies suggest that peroxisome proliferator-activated receptor gamma (PPARγ) agonists may have cancer chemopreventive activity. " 08/01/2010 - "In this meta-analysis, we assessed published studies of the association between two common PPARgamma polymorphisms and cancer risk from 26 studies with 27,677 subjects for PPARgamma P12A, from 4 studies with 4,461 subjects for C161T. " 12/15/2009 - "Collectively, these studies suggest that activated PPARgamma induces Angptl4 to promote tumor growth through enhanced angiogenesis in vivo." 10/01/2009 - "The aim of the present study was to investigate the association of PPARgamma expression with the degree of differentiation and ploidy status of benign and malignant thyroid neoplasias. " 02/01/2009 - "The findings of the present study suggest that in BUC, PPARgamma expression can identify patients with a better prognosis who suffer from more differentiated, non-invasive tumors, of a low proliferative potential."
5.	Hypertension (High Blood Pressure) 01/01/2009 - "We suggest that downregulation of PPARgamma but upregulation of GRK-2 increases blood pressure and impaired renal vascular reactivity in SHR and that PPARgamma-mediated improvement in hypertension may involve transcriptional regulation of GRK-2 function." 01/01/2009 - "In this study we investigated the role of GRK-2 in PPARgamma-mediated blood pressure regulation in hypertension. " 12/01/2008 - "The Pro12Ala polymorphism of PPAR gamma 2 has been shown to influence hypertension and the benefit of longevity in previous studies. " 09/01/2010 - "These results demonstrate the first known association between a PPARgamma single nucleotide polymorphism and alterations in PRA levels in humans with hypertension. " 08/20/2010 - "From the mechanistic viewpoint, OA-NO(2) lowers Ang II-induced hypertension independently of peroxisome proliferation-activated receptor (PPAR)gamma activation. "

Related Drugs and Biologics

1.	Ligands
2.	PPAR gamma
3.	Rosiglitazone (Avandia)
4.	Insulin (Novolin)
5.	Pioglitazone (Actos)
6.	Peroxisome Proliferator-Activated Receptors (PPAR)
7.	PPAR alpha
8.	Thiazolidinediones
9.	Glucose (Dextrose)
10.	2,4-thiazolidinedione (thiazolidinedione)

Related Therapies and Procedures

1.	Therapeutics
2.	Glycemic Control
3.	Chemoprevention
4.	Oral Administration
5.	Chinese Traditional Medicine (Traditional Chinese Medicine)