|1.||Lamph, William W: 8 articles (05/2008 - 11/2002)|
|2.||Grubbs, Clinton J: 7 articles (07/2015 - 08/2003)|
|3.||Muccio, Donald D: 6 articles (07/2015 - 08/2003)|
|4.||Kagechika, Hiroyuki: 6 articles (01/2015 - 10/2004)|
|5.||Kakuta, Hiroki: 6 articles (09/2014 - 03/2008)|
|6.||Moriwaki, Hisataka: 6 articles (10/2012 - 02/2002)|
|7.||Christov, Konstantin: 5 articles (01/2014 - 10/2004)|
|8.||Shimizu, Masahito: 5 articles (10/2012 - 11/2007)|
|9.||Makishima, Makoto: 5 articles (05/2012 - 03/2008)|
|10.||Tai, Akihiro: 5 articles (05/2012 - 03/2008)|
01/01/2014 - "Methyl-substituted conformationally constrained rexinoid agonists for the retinoid X receptors demonstrate improved efficacy for cancer therapy and prevention."
01/01/2015 - "Various retinoid X receptor (RXR) agonists have recently been developed, and some of them have shown anti-tumor effects both in vivo and in vitro. "
06/01/2013 - "We recently reported that an N-terminally truncated retinoid X receptor-α (tRXRα) produced in cancer cells acts to promote cancer cell growth and survival through AKT activation. "
01/01/2013 - "A truncated version of retinoid X receptor-α, tRXR-α, promotes cancer cell survival by activating the phosphoinositide 3-kinase (PI3K)/AKT pathway. "
10/01/2012 - "We correlated VDR, retinoid X receptor (RXR), and MIB-1 (Ki-67) expression in 110 archived OS cases with several clinicopathologic parameters including patient's age, sex, tumor location, tumor grade, and type and metastatic status. "
10/01/2010 - "Differential expression and cross-talk of peroxisome proliferator-activated receptor γ and retinoid-X receptor α in urothelial carcinomas of the bladder."
01/01/2006 - "It should be emphasized that most breast carcinomas and breast cancer cell lines show loss or down-regulation of RARbeta receptor expression, whereas RARalpha and gamma, as well as retinoid X receptors, appear to be variably expressed in both normal and tumour cells. "
01/01/2015 - "Notably, the expression of retinoic acid receptor (RAR-β) and retinoid X receptors (RXR-β, -γ) was significantly upregulated in sebaceous cell carcinoma of the eyelids. "
08/01/2013 - "In order to investigate the inhibitory effects and mechanisms of troglitazone (TGZ), a peroxisome proliferator-activated receptor γ (PPARγ) agonist, and retinoid X receptor (RXR) agonist (9-cis-retinoic acid (RA)) on gastric carcinoma cells SGC7901, SGC7901 cells were treated with TGZ and 9-cis-RA, respectively, or in combination. "
04/16/2010 - "Ligands that activate the nuclear receptor retinoid X receptor (RXR) display potent anticarcinogenic activities, but the mechanisms by which these compounds inhibit carcinoma cell growth are poorly understood. "
|3.||Alzheimer Disease (Alzheimer's Disease)
09/05/2015 - "Small molecule TBTC as a new selective retinoid X receptor α agonist improves behavioral deficit in Alzheimer's disease model mice."
01/01/2014 - "Potential retinoid x receptor agonists for treating Alzheimer's disease from traditional chinese medicine."
01/01/2014 - "Hence, we propose β -lipoic acid and sulfanilic acid as potential lead compounds for further study in drug development process with the RXR protein against Alzheimer's disease. "
09/01/2014 - "The nuclear retinoid X receptor agonist, bexarotene, has been implicated in recovery of cognitive function in mouse models of Alzheimer's disease (AD). "
01/01/2014 - "Cooperative therapeutic action of retinoic acid receptor and retinoid x receptor agonists in a mouse model of Alzheimer's disease."
|4.||Neoplasm Metastasis (Metastasis)
03/13/2006 - "The present study determined the influence of a retinoid X receptor agonist bexarotene on angiogenesis and metastasis in solid tumours. "
03/13/2006 - "A selective retinoid X receptor agonist bexarotene (LGD1069, targretin) inhibits angiogenesis and metastasis in solid tumours."
01/01/1999 - "LGD-1069 is a retinoid X receptor agonist that modulates cell proliferation, and BAY-129566, a matrix metalloproteinase inhibitor, appears to interrupt both the processes of angiogenesis and metastasis. "
04/01/2008 - "To evaluate the effects of pretreatment with the retinoid X receptor (RXR) agonist bexarotene on the efficacy of radioiodine therapy for metastases of differentiated thyroid carcinoma (DTC) with limited uptake of radioiodine (I-131). "
03/01/2011 - "Retinoid X receptor γ up-regulation is correlated with dedifferentiation of tumor cells and lymph node metastasis in papillary thyroid carcinoma."
|5.||Prostatic Neoplasms (Prostate Cancer)
11/01/2015 - "Others have shown in prostate cancer cells that exogenous IGFBP-3 induces apoptosis by facilitating nuclear export of the orphan nuclear receptor Nur77 and its binding partner, retinoid X receptor-α (RXRα). "
04/01/2009 - "Chromatin immunoprecipitation assays showed that VDR and retinoid X receptor were present on the MIS promoter in prostate cancer cells. "
02/15/2006 - "A selective retinoid X receptor agonist bexarotene (LGD1069, Targretin) prevents and overcomes multidrug resistance in advanced prostate cancer."
07/01/1997 - "Effects of retinoid X receptor-selective ligands on proliferation of prostate cancer cells."
07/01/2005 - "Combination therapy of insulin-like growth factor binding protein-3 and retinoid X receptor ligands synergize on prostate cancer cell apoptosis in vitro and in vivo."
|4.||Peroxisome Proliferator-Activated Receptors (PPAR)
|7.||Cytoplasmic and Nuclear Receptors (Nuclear Receptors)
|9.||Tretinoin (Retinoic Acid)
|1.||Drug Therapy (Chemotherapy)
|4.||Renal Replacement Therapy (Therapies, Renal Replacement)
|5.||Heterologous Transplantation (Xenotransplantation)