Calixarenes (Calixarene)

Phenolic metacyclophanes derived from condensation of PHENOLS and ALDEHYDES. The name derives from the vase-like molecular structures. A bracketed [n] indicates the number of aromatic rings.

Also Known As:

Networked: 56 relevant articles (3 outcomes, 5 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Guo, Dong-Sheng: 5 articles (05/2022 - 01/2020)
2.	Liu, Yang: 3 articles (01/2022 - 07/2020)
3.	Shi, Linqi: 3 articles (01/2022 - 07/2020)
4.	Mo, Jingxin: 3 articles (07/2020 - 11/2017)
5.	Li, Hua-Bin: 2 articles (01/2022 - 01/2021)
6.	Zheng, Yadan: 2 articles (01/2022 - 01/2021)
7.	Zhang, Tian-Xing: 2 articles (01/2021 - 07/2020)
8.	Li, Meiying: 2 articles (07/2020 - 01/2019)
9.	Ding, Dan: 2 articles (01/2020 - 01/2020)
10.	An, Lin: 2 articles (01/2019 - 11/2016)

Related Diseases

1.	Infections 10/01/2020 - "Novel calixarene-based surfactant enables low dose split inactivated vaccine protection against influenza infection." 10/14/2021 - "We report two novel p-tBu-calixarene glycoclusters 1 and 2, bearing tetrahydroxamic acid groups, which exhibit micromolar inhibition of soluble DC-SIGN binding and provide nanomolar IC50 inhibition of both DC-SIGN-dependent Jurkat cis-cell infection by viral particle pseudotyped with Ebola virus glycoprotein and the HCMV-gB-recombinant glycoprotein interaction with monocyte-derived dendritic cells expressing DC-SIGN. " 05/01/1985 - "Some homologous calixarenes or polyoxyethylene ethers that are known to suppress or enhance experimental tuberculous infection (depending on their polyoxyethylene chain lengths) were examined for their effects on phospholipid bilayers. "
2.	Glioblastoma (Glioblastoma Multiforme) 11/02/2021 - "The calixarene-based nanocontainer appears to be a promising new candidate for nanocarrier-based drug combination therapy for glioblastoma." 01/01/2019 - "Encapsulation of Temozolomide in a Calixarene Nanocapsule Improves Its Stability and Enhances Its Therapeutic Efficacy against Glioblastoma." 01/01/2017 - "Docetaxel-Loaded Nanoparticles Assembled from β-Cyclodextrin/Calixarene Giant Surfactants: Physicochemical Properties and Cytotoxic Effect in Prostate Cancer and Glioblastoma Cells."
3.	Human Influenza (Influenza) 06/03/2019 - "Size and Flexibility Define the Inhibition of the H3N2 Influenza Endonuclease Enzyme by Calix[n]arenes." 10/01/2020 - "Novel calixarene-based surfactant enables low dose split inactivated vaccine protection against influenza infection." 10/01/2020 - "Here, we report the use of the novel calixarene-based surfactant CALX133ACE as an alternative to classical detergents for influenza inactivated split vaccine preparation. " 06/03/2019 - "Inhibition of H3N2 influenza PA endonuclease activity by a panel of anionic calix[n]arenes and β-cyclodextrin sulfate has been studied. " 10/01/2020 - "Taken together, our results demonstrate for the first time the use of a calixarene-based detergent as an efficient splitting agent for the production of optimized influenza split antigens, paving the way for significant improvement in the vaccine manufacturing process, notably with regard to the current regulation on the prohibition of endocrine disruptors, such as Triton X-100."
4.	Bites and Stings (Sting) 06/01/2015 - "The present work aims at studying the decontamination efficacy of a calixarene-loaded nanoemulsion on two ex vivo wounded skin models mimicking superficial stings or cuts contaminated with uranium, and on a third model using excoriation. " 07/04/2005 - "The 1,3-alternate calixarene conformations afford "open-mouth" pac-man structures whose ability to bite on nitrogen bidentates depends on their functionalization. "
5.	Neoplasms (Cancer) 01/07/2015 - "Calixarene 0118 is a potent anti-angiogenic agent that effectively inhibited tumor growth in preclinical studies, and is currently being evaluated in a phase I clinical trial. " 01/01/2024 - "Calixarene: A Supramolecular Material for Treating Cancer." 01/01/2023 - "Calixarene also possesses good biocompatibility and innocuousness and gained attention for cancer treatment due to the response to multiple stimuli, stability, avoiding non-specific cell uptake, and reaching the target for treatment effect. " 01/01/2022 - "The fluorescent tracer conjugation in the calixarene enables the self-probed tumor targeting analysis and makes the system potentially suitable for tumor diagnostic imaging." 01/01/2020 - "Calixarene-Based Supramolecular AIE Dots with Highly Inhibited Nonradiative Decay and Intersystem Crossing for Ultrasensitive Fluorescence Image-Guided Cancer Surgery."

Related Drugs and Biologics

1.	Surface-Active Agents (Surfactants)
2.	Uranium
3.	Nanocapsules
4.	Endocrine Disruptors
5.	Octoxynol (Triton X 100)
6.	Inactivated Vaccines
7.	Vaccines
8.	Detergents (Detergent)
9.	Antigens
10.	Temozolomide (Temodar)

Related Therapies and Procedures

1.	Therapeutics
2.	Catheters
3.	Drug Therapy (Chemotherapy)
4.	Chinese Traditional Medicine (Traditional Chinese Medicine)