|1.||Nunes, Ricardo José: 8 articles (01/2015 - 09/2008)|
|2.||Winter, Evelyn: 6 articles (01/2015 - 05/2013)|
|3.||Yunes, Rosendo Augusto: 6 articles (08/2014 - 12/2008)|
|4.||Chiaradia, Louise Domeneghini: 5 articles (08/2014 - 12/2008)|
|5.||Mascarello, Alessandra: 5 articles (01/2014 - 12/2008)|
|6.||Di Pietro, Attilio: 4 articles (01/2015 - 04/2012)|
|7.||Diederich, Marc: 4 articles (09/2014 - 04/2006)|
|8.||Haratake, Mamoru: 4 articles (09/2010 - 10/2007)|
|9.||Ono, Masahiro: 4 articles (09/2010 - 10/2007)|
|10.||Nakayama, Morio: 4 articles (09/2010 - 10/2007)|
06/15/2015 - "With the knowledge of molecular targets, structural insights and SARs, this review may be helpful for (medicinal) chemists to design more potent, safe, selective and cost effective anti-cancer chalcones. "
01/01/2015 - "This review summarizes the anticancer activities shown by natural chalcones and the SAR and describes how different chemical moiety modifications could lead them to be therapeutically useful in the treatment of cancer. "
04/22/2014 - "In the present study, a series of 46 chalcones were synthesised and evaluated for antiproliferative activities against the human TRAIL-resistant breast (MCF-7, MDA-MB-231), cervical (HeLa), ovarian (Caov-3), lung (A549), liver (HepG2), colorectal (HT-29), nasopharyngeal (CNE-1), erythromyeloblastoid (K-562) and T-lymphoblastoid (CEM-SS) cancer cells. "
06/01/2013 - "Recent studies report that chalcones exhibit cytotoxicity to human cancer cell lines. "
01/01/2012 - "Our study has indicated that chalcones augment the antitumor activity of TRAIL and confirm their cancer chemopreventive properties."
|2.||Prostatic Neoplasms (Prostate Cancer)
04/01/2011 - "The results suggest the multitarget efficacy of 4-maleamic acid and 4-maleamide peptidyl chalcones against human prostate cancer cells and emphasize the potential therapeutic relevance of these compounds."
02/15/2009 - "We report the SAR studies of 43 ionone-based chalcones that demonstrate substantial in vitro anti-proliferative activities in LNCaP, MDA-PCa-2b, 22Rv1, C4-2B and PC-3 prostate cancer cell lines. "
10/01/2013 - "Novel methylsulfonyl chalcones as potential antiproliferative drugs for human prostate cancer: involvement of the intrinsic pathway of apoptosis."
07/01/2012 - "Synthesis and selective cytotoxic activity of novel hybrid chalcones against prostate cancer cells."
04/01/2011 - "New 4-maleamic acid and 4-maleamide peptidyl chalcones as potential multitarget drugs for human prostate cancer."
10/15/2013 - "The aim of this study was to synthesize three nitro substituted chalcones and to evaluate their anti-inflammatory activity in the model of carrageenan induced edema in rats. "
04/01/2011 - "Chalcones of 2a-f and their corresponding products, pyrazolines 3a-f, were synthesized and evaluated for their anti-inflammatory activity against carrageenan edema in albino rats at a dose of 10 mg/kg. All the compounds of this series showed promising anti-inflammatory activity. "
06/01/2013 - "Some unnatural chalcones (1a-q) and flavones (2a-d) have been synthesized and evaluated for their antiinflammatory activity using carrageenan-induced rat paw edema assay. "
05/01/2006 - "The synthesis of 1,3-diaryl propen-1-ones (chalcones) by the Claisen-Schmidt condensation between acetophenones and benzaldehydes in potassium hydroxide/methanol medium at room temperature yielded: 1-(4-nitrophenyl)-3-(2,4,6-trimethoxyphenyl)propen-1-one (3a), 1-(4-nitrophenyl)-3-(3-bromophenyl)propen-1one (3b), 1-(4-methoxyphenyl)-3-(3-bromophenyl)propen-1-one (3c), 1-(4-methoxyphenyl)-3-(2,4,6-trimethoxyphenyl)propen-1-one (3d), 1-(2,4-dihydroxyphenyl)-3-(phenyl)propen-1-one (3e), 1-(4-nitrophenyl)-3-(4-chlorophenyl)propen-1-one (3f) which were evaluated for anti-inflammatory activity at doses of 20, 40 and 80mg/kg. The compounds were found to be effective inhibitors of carrageenan-induced rat paw edema in Wistar rats and this activity was dose dependent and increased between the third and fourth hour. "
10/01/2014 - "We synthesized racemic mixtures of these flavanones from corresponding chalcones and herein we report for the first time the molecular mechanisms of cell death, anti-proliferative effect and ability to induce apoptosis in human cervical carcinoma (HeLa) cells. "
01/01/2014 - "In this study, a group of recently synthesized chalcones, with the structure of 1,3-diarylprop-2-en-1-one having different COX-1 and/or COX-2 selectivities have been examined on human hepatocarcinoma (HepG2), lung carcinoma (A549), and breast adenocarcinoma (MCF-7) cell line, using Sulforhodamine B (SRB) assay. "
02/01/2001 - "Fourteen novel C-prenylated and O-allylated 1,3-diarylpropenones (chalcones) were synthesized by Claisen-Schmidt condensation reaction of C-prenylated/O-allylated acetophenones with appropriate aldehydes; twelve of these model chalcones were screened in an assay based on the confrontation of invasive human MCF-7/6 mammary carcinoma cells with fragments of normal embryonic chick heart in vitro. "
01/01/2012 - "Chalcones promoted 1 of the 2 steps in a rapid, convergent synthesis of a small library of hydrazinyl pyrazole derivatives, all of which exhibited significant antitumor activity against Ehrlich Ascites Carcinoma (EAC) human tumor cell line comparable to that of the natural anticancer doxorubicin, as a reference standard during this study. "
05/15/2007 - "A series of synthetic chalcones, flavanones, and flavones has been synthesized and evaluated for antitumor activity against the human kidney carcinoma cells TK-10, human mammary adenocarcinoma cells MCF-7 (estrogen receptor-positive), and human colon adenocarcinoma cells HT-29. "
03/01/2011 - "The current review, however, deals with the role of various chalcones in inflammation that controls both the immune system and tumorigenesis. "
10/01/2008 - "Chalcones and their potential role in inflammation."
09/01/2012 - "This study demonstrates that chalcones can serve as lead compounds in the development of dual inhibitors against both targets in the treatment of inflammation and cancer."
03/01/2011 - "The role of chalcones in suppression of NF-κB-mediated inflammation and cancer."
09/15/2008 - "Chalcones or 1,3-diaryl-2-propen-1-ones are known to be useful for treating pain, inflammation, and certain diseases although their uses have not been scientifically verified. "
|6.||Type II DNA Topoisomerases (Topoisomerase II)
|8.||Proteasome Endopeptidase Complex (Proteasome)
|9.||Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
|10.||Vascular Endothelial Growth Factor Receptor-2 (Vascular Endothelial Growth Factor Receptor 2)
|2.||Traditional Medicine (Folk Remedies)
|3.||Drug Therapy (Chemotherapy)