Pyrazolones

08/01/2009 - "The study included 51 patients with selective immediate allergic reactions to pyrazolones and 56 controls. "
04/01/2003 - "FAST and CAST are useful for the diagnosis of allergy to pyrazolones. "
10/01/2000 - "Hypersensitivity to pyrazolones."
10/01/1985 - "[Comments on 198 cases of allergy to pyrazolones]."
01/01/1986 - "Allergic reactions and leucopenia or agranulocytosis occurring in single cases only were associated with the use of pyrazolones. "

07/19/2013 - "A series of β-keto esters were synthesized from ketones and ethyl chloroformate in the presence of base which in turn are converted to pyrazolones and then subjected to cytotoxicity studies towards various cancer cell lines and antimicrobial activity studies towards various bacterial and fungal strains. "

06/01/1999 - "Patients were divided into three groups: A = 69 subjects with chronic urticaria, B = 163 otherwise normal subjects with a history of urticaria after the ingestion of aspirin, and C = 24 otherwise normal subjects with a history of urticaria after the ingestion of pyrazolones but aspirin-tolerant. "
08/01/1983 - "About one third of patients with anaphylactic reactions to pyrazolones showed contact urticaria induced by to at least one pyrazolone after 30-60 min in patch test. "
01/01/2019 - "An 80-year-old man with a history of allergy to pyrazolones, with good tolerance to other NSAIDs was referred to our allergy department because he presented a generalized urticaria after the administration of Intravenous (IV) paracetamol. "
09/01/1995 - "We enrolled 67 subjects with documented intolerance to aspirin, pyrazolones or NSAIDs, clinically manifested as urticaria/angioedema (68%), asthma, and/or rhinitis (32%). "
06/01/2005 - "Methods One hundred and seventeen otherwise normal subjects with a history of acute urticaria following the ingestion of a single NSAID (pyrazolones (n=58), nimesulide (n=17), propionic acid derivatives (n=13), aryl acetic acid derivatives (n=14), acetaminophen (n=9), piroxicam (n=5), and indometacin (n=1)) underwent single-blind placebo-controlled oral challenges with aspirin. "

06/01/2010 - "However, in spite of its recognized therapeutic benefits, the use of pyrazolones has been associated with agranulocytosis. "
01/01/1986 - "Agranulocytosis occurred predominantly with pyrazolones, with a mortality of 1 to 2 per 10 million users per year. "
11/14/1983 - "The pyrazolones, although not associated with teratogenic side effects, may lead to sometimes fatal agranulocytosis and, accordingly, are not recommended in pregnancy. "
01/01/1986 - "Allergic reactions and leucopenia or agranulocytosis occurring in single cases only were associated with the use of pyrazolones. "
11/14/1983 - "The pyrazolones (amidopyrine, dipyrone and butazones), phenothiazine derivatives, antithyroid drugs, and antibiotics are thought to be causative agents in agranulocytosis. "

03/31/2016 - "Pyrazolones metabolites are relevant for identifying selective anaphylaxis to metamizole."
08/01/1983 - "About one third of patients with anaphylactic reactions to pyrazolones showed contact urticaria induced by to at least one pyrazolone after 30-60 min in patch test. "
01/01/2021 - "Using just four variables (Pru p 3 sensitization, Tri a 19 sensitization, anaphylaxis, and any NSAID different from pyrazolones), 95.3% of cases were correctly classified, with a sensitivity of 92% and specificity of 96%. "
01/01/2019 - "We present an anaphylactic shock due to sensitization to paracetamol because of a type I hypersensitivity mechanism, diagnosed by SBOCT and a positive IDT because of flare-up phenomenon, in a patient with previous pyrazolones allergy and with tolerance to other NSAIDs. "