Sericins (Sericin)

A serine-rich sticky protein secreted by MOTHS. Generally, the term refers to silkworm silk gum protein secreted in the middle section of silk gland cells of SILKWORMS, Bombyx mori. Sericin acts as a cement and coating for the two fibroin filaments in a silk strand and is readily soluble in mild alkaline solution.

Also Known As:

Networked: 228 relevant articles (25 outcomes, 66 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Aramwit, Pornanong: 24 articles (12/2022 - 10/2007)
2.	Sasaki, Masahiro: 11 articles (02/2020 - 11/2002)
3.	Wang, Lin: 9 articles (06/2022 - 11/2015)
4.	Wang, Zheng: 9 articles (06/2022 - 11/2015)
5.	Ampawong, Sumate: 7 articles (12/2022 - 01/2016)
6.	Zhao, Ping: 7 articles (01/2022 - 11/2017)
7.	He, Huawei: 7 articles (02/2021 - 11/2017)
8.	Tao, Gang: 7 articles (02/2021 - 11/2017)
9.	Wang, Yejing: 7 articles (02/2021 - 11/2017)
10.	Wang, Guobin: 6 articles (06/2022 - 03/2016)

Related Diseases

1.	Wounds and Injuries (Trauma) 01/01/2023 - "In comparison with controls, 4% sericin + jasmine (S + J) expressively improved wound contraction area. " 04/01/2016 - "The objective of this study was to evaluate in vivo wound healing effects of a sericin-containing gel formulation in an incision wound model in rats. " 01/01/2016 - "In this study, we aimed to develop wound dressing materials which are easier to apply and to provide extended release of sericin. " 05/01/2023 - "Our findings suggest that the sericin wound dressing has promising application and commercial value in wound repair." 05/01/2023 - "Importantly, we confirmed good cell compatibility of sericin wound dressing that can support cell viability, proliferation, and migration for a long time. "
2.	Neoplasms (Cancer) 10/15/2003 - "The protective effect of sericin was evident in terms of significant reduction in tumor incidence and tumor multiplicity at the dose of 5 mg. The results suggest that sericin possesses photoprotective effect against UVB-induced acute damage and tumor promotion by reducing oxidative stress, COX-2 and cell proliferation in mouse skin." 05/01/2003 - "The protective effect of sericin was evident in terms of significant reduction in tumor incidence and tumor multiplicity at the doses of 2.5 and 5 mg per application, compared to the control group without receiving sericin. " 01/01/2019 - "In the present study, we have evaluated the pro-oxidative effect of Bombyx mori sericin (BMS), Antheraea assamensis sericin (AAS), and Philosamia ricini sericin (PRS) against different cancer cells. " 06/01/2007 - "This study was conducted to examine the mechanisms of the anti-colon tumor effect of dietary sericin. " 02/14/2023 - "Conclusions: Conclusively, the LDH-sericin nanohybrids loaded with PMX and conjugated to ZnO QDs offered a promising cancer theranostic nanomedicine."
3.	Burns 01/01/2023 - "It is concluded that a mixture of sericin and jasmine leaves effectively improved the healing process of skin burns." 09/01/2013 - "Silk sericin ameliorates wound healing and its clinical efficacy in burn wounds." 08/01/2013 - "Silk sericin and burn wound." 09/01/2013 - "This is the first clinical study to show that silk sericin is safe and beneficial for burn wound treatment when it is added to silver sulfadiazine cream. " 09/01/2013 - "For applicable result in clinical use, we also study the efficacy of sericin added to a standard antimicrobial cream, silver zinc sulfadiazine, for open wound care in the treatment of second-degree burn wounds. "
4.	Obesity 01/01/2020 - "To investigate the effects of sericin extracted from silkworm Bombyx mori cocoon on morphophysiological parameters in mice with obesity induced by high-fat diet. " 01/01/2020 - "Sericin as treatment of obesity: morphophysiological effects in obese mice fed with high-fat diet." 01/01/2020 - "Physiological changes induced by obesity were not fully reverted by sericin; however, sericin treatment restored jejunal morphometry and increased lipid excretion in feces in obese mice, suggesting potential anti-obesity effects." 04/27/2011 - "These findings illustrate that silk protein, particularly sericin, may be beneficial in the prevention of high fat diet-induced hyperlipidemia and obesity." 01/01/2016 - "The antioxidant activity associated with low digestibility of sericin that expands the application in the medical field, such as antitumour, antimicrobial and anti-inflammatory agent, anticoagulant, acts in colon health, improving constipation and protects the body from obesity through improved plasma lipid profile. "
5.	Inflammation (Inflammations) 02/01/2021 - "This study aimed to examine the effects of sericin administration on episodic and avoidance memories, social interaction behavior, and molecular mechanisms including oxidative stress, inflammation, and apoptosis in the hippocampus of aged mice. " 03/05/2020 - "In the sub-acute toxicity study, there were no toxicological effects in any of the estimated parameters, while histopathological analysis showed inflammation in vital organs at the dose of 2000 mg/kg. Results of our acute toxicity study suggest that sericin is safe at all administered doses, while the sub-acute study suggests that the NOAEL (no-observed-adverse-effect level) of sericin is below 2000 mg/kg, at which it can be considered safe." 01/01/2019 - "This study was aimed to examine the effects of sericin administration on restraint stress induced anxiety- and depressive-like behaviors, oxidative stress, inflammation and apoptosis in the prefrontal cortex (PFC) and hippocampus (HIP) of mice. " 03/01/2023 - "In this article, this property of Sericin is discussed in detail, and according to the experiments performed by pharmacists, this substance has shown a significant effect in eliminating inflammation. " 01/01/2023 - "Effects of sericin and egg white on the inflammation of damaged skin in mice."

Related Drugs and Biologics

1.	Silk
2.	Hydrogels
3.	Proteins (Proteins, Gene)
4.	Antioxidants
5.	Silver
6.	polihexanide
7.	Chitosan
8.	Collagen
9.	Transforming Growth Factor beta (TGF-beta)
10.	Sulfadiazine (Sulphadiazine)

Related Therapies and Procedures

1.	Therapeutics
2.	Injections
3.	Microspheres (Microsphere)
4.	Intraperitoneal Injections
5.	Artificial Skin