|1.||Moody, Christopher J: 2 articles (10/2013 - 12/2011)|
|2.||Münster, P N: 2 articles (08/2001 - 04/2001)|
|3.||Rosen, N: 2 articles (08/2001 - 04/2001)|
|4.||De Silva, Ravindra A: 1 article (08/2014)|
|5.||Lisok, Ala: 1 article (08/2014)|
|6.||G Lesniak, Wojciech: 1 article (08/2014)|
|7.||Pomper, Martin G: 1 article (08/2014)|
|8.||Behnam Azad, Babak: 1 article (08/2014)|
|9.||Mease, Ronnie C: 1 article (08/2014)|
|10.||Pullambhatla, Mrudula: 1 article (08/2014)|
02/14/2002 - "Thus, pharmacological inhibition of Akt activation is achievable with ansamycins and may be useful for the treatment of HER2 driven tumors."
06/01/2011 - "Macrocyclic lactams as potent Hsp90 inhibitors with excellent tumor exposure and extended biomarker activity."
06/01/1995 - "New triene-ansamycins designated thiazinotrienomycins A, B, C, D and E were isolated from culture broth of Streptomyces sp. MJ672-m3 for their activities against cervical cancer cell lines. "
05/02/2006 - "Therefore, the in vivo accumulation of the high-affinity dihydroquinone ansamycins in tumor cells contributes to the antitumor activity of these compounds and alters our understanding of the active species driving the efficacy of this class of compounds."
08/01/2014 - "The biodistribution and PET/CT imaging studies with the radiolabeled bridged cyclams demonstrated longer tumor retention and comparable uptake to [(64)Cu]AMD3465, though [(64)Cu]AMD3465 demonstrated superior overall pharmacokinetics. "
|2.||Breast Neoplasms (Breast Cancer)
08/01/2001 - "Modulation of Hsp90 function by ansamycins sensitizes breast cancer cells to chemotherapy-induced apoptosis in an RB- and schedule-dependent manner. "
08/01/2001 - "Münster et al., Modulation of Hsp90 function by ansamycins sensitizes breast cancer cells to chemotherapy-induced apoptosis in an RB- and schedule-dependent manner. "
10/01/2006 - "An isogenic pair of human breast cancer cell lines, MDA468 and MDA468/NQ16, differing in expression of NQO1, was used, and HPLC analysis showed that hydroquinone ansamycins were formed by the MDA468/NQ16 cells, which could be prevented by ES936 pretreatment. "
04/01/2001 - "Inhibition of heat shock protein 90 function by ansamycins causes the morphological and functional differentiation of breast cancer cells."
|3.||Leprosy (Hansen's Disease)
04/01/1994 - "Anti-leprosy activity of ofloxacin and ansamycins in mice."
|4.||Glioblastoma (Glioblastoma Multiforme)
|5.||Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental)
|4.||N-(1,4,8,11- tetraazacyclotetradecanyl- 1,4- phenylenebis(methylene))- 2- (aminomethyl)- pyridine
|6.||hydroquinone (Black and White)
|7.||Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)
|1.||Drug Therapy (Chemotherapy)