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Nesidioblastosis (Nesidioblastosis of Pancreas)

An inherited autosomal recessive syndrome characterized by the disorganized formation of new islets in the PANCREAS and PERSISTENT HYPERINSULINEMIA HYPOGLYCEMIA OF INFANCY. It is due to focal hyperplasia of pancreatic ISLET CELLS budding off from the ductal structures and forming new islets of Langerhans. Mutations in the islet cells involve the potassium channel gene KCNJ11 or the ATP-binding cassette transporter gene ABCC8, both on CHROMOSOME 11.
Also Known As:
Nesidioblastosis of Pancreas; Pancreatic Nesidioblastosis; Nesidioblastosis, Pancreatic; Hyperinsulinism, Familial, with Pancreatic Nesidioblastosis
Networked: 217 relevant articles (6 outcomes, 15 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Diabetes Mellitus
2. Insulinoma
3. Hypoglycemia (Reactive Hypoglycemia)
4. Hyperplasia
5. Neoplasms (Cancer)

Experts

1. Perren, Aurel: 3 articles (12/2015 - 12/2006)
2. Service, F John: 3 articles (11/2015 - 07/2005)
3. Thompson, Geoffrey B: 3 articles (11/2015 - 07/2005)
4. Schmid, Christoph: 2 articles (12/2015 - 12/2006)
5. Andrews, James C: 2 articles (11/2015 - 07/2005)
6. Grant, Clive S: 2 articles (11/2015 - 02/2009)
7. Vella, Adrian: 2 articles (11/2015 - 02/2009)
8. Rumilla, Kandelaria M: 2 articles (11/2015 - 02/2009)
9. Damani, Tanuja: 2 articles (01/2013 - 06/2011)
10. Lloyd, Ricardo V: 2 articles (02/2009 - 07/2005)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Nesidioblastosis:
1. Diazoxide (Hyperstat)FDA Link
2. Insulin (Novolin)FDA Link
3. Glucose (Dextrose)FDA LinkGeneric
4. Phosphopyruvate Hydratase (Enolase)IBA
5. Growth Hormone (Somatotropin)IBA
6. Somatostatin (Somatotropin Release-Inhibiting Factor)IBA
7. Glucagon (Glukagon)FDA Link
8. CalciumIBA
9. Pancreatic Polypeptide (Pancreatic Polypeptide (PP))IBA
10. Octreotide (Sandostatin)FDA LinkGeneric

Therapies and Procedures

1. Pancreatectomy
2. Gastric Bypass (Roux-en-Y Gastric Bypass)
3. Splenectomy
4. Catheters
5. Bariatric Surgery