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Lymphocytic Colitis

A subtype of MICROSCOPIC COLITIS, characterized by chronic watery DIARRHEA of unknown origin, a normal COLONOSCOPY but abnormal histopathology on BIOPSY. Microscopic examination of biopsy samples taken from the COLON show infiltration of LYMPHOCYTES in the superficial EPITHELIUM and the underlying connective tissue (lamina propria).
Also Known As:
Colitis, Lymphocytic
Networked: 203 relevant articles (13 outcomes, 16 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Collagenous Colitis
2. Ulcerative Colitis
3. Microscopic Colitis
4. Celiac Disease (Celiac Sprue)
5. Colitis

Experts

1. Chande, Nilesh: 5 articles (01/2017 - 04/2007)
2. Münch, Andreas: 4 articles (01/2020 - 01/2015)
3. Miehlke, Stephan: 4 articles (12/2018 - 06/2009)
4. Pardi, Darrell S: 4 articles (01/2017 - 04/2002)
5. Khalili, Hamed: 3 articles (06/2022 - 01/2015)
6. Rubio, Carlos A: 3 articles (12/2015 - 06/2011)
7. Tysk, C: 3 articles (11/2013 - 05/2000)
8. Villanacci, Vincenzo: 2 articles (02/2021 - 04/2015)
9. Chojnacki, Cezary: 2 articles (01/2021 - 01/2018)
10. Chojnacki, Jan: 2 articles (01/2021 - 01/2018)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Lymphocytic Colitis:
1. Budesonide (Pulmicort)FDA LinkGeneric
2. Mesalamine (Mesalazine)FDA LinkGeneric
3. Cholestyramine Resin (Questran)FDA LinkGeneric
4. bismuth subsalicylate (Pepto-bismol)FDA LinkGeneric
5. Beclomethasone (Beclometasone)FDA Link
6. Ticlopidine (Ticlid)FDA LinkGeneric
7. RNA (Ribonucleic Acid)IBA
8. MicroRNAs (MicroRNA)IBA
9. CollagenIBA
10. Immunoglobulin A (IgA)IBA

Therapies and Procedures

1. Therapeutics
2. Remission Induction
3. Gluten-Free Diet
08/18/1989 - "Three of the patients with lymphocytic colitis and celiac-like changes of the small bowel never responded to a gluten-free diet and may represent a distinctive panintestinal disease for which the term "lymphocytic enterocolitis" with malabsorption is proposed."
12/01/1998 - "Mild colonic lymphocytosis in patients with untreated celiac sprue should be distinguished from lymphocytic colitis by the lack of surface epithelial abnormalities, the lack of increased cellularity of the lamina propria, and the lack of ongoing watery diarrhea after treatment with a gluten-free diet. "
04/01/2006 - "If a patient is not responding well to a gluten-free diet, three considerations are necessary: (1) the initial diagnosis of celiac disease must be reassessed;(2) the patient should be sent to a dietician to check for errors in diet or compliance problems, because problems with the gluten-free diet are the most important cause for persisting symptoms; (3) other reasons for persisting symptoms (eg, pancreatic insufficiency, irritable bowel syndrome, bacterial overgrowth, lymphocytic colitis, collagenous colitis, ulcerative jejunitis, protein-losing enteropathy,T-cell lymphoma, fructose intolerance, cavitating lymphadenopathy, and tropical sprue) should be considered. "
02/01/2003 - "We compared the frequency of lymphocytic gastritis (LG) and lymphocytic colitis (LC), together with IEL phenotype and T cell clonality, in gastric and colonic samples from 15 adults with RCS (all with aberrant CD3 intracytoplasmic(+) surface(-) CD8(-) clonal IELs on duodenojejunal biopsies), 18 patients with active coeliac disease (ACD), and 10 patients with coeliac disease (CD) on a gluten free diet (GFD-CD) by means of immunohistochemistry and multiplex polymerase chain reaction amplification of the T cell receptor gamma gene (TCR-gamma) rearrangement. "
4. Immunotherapy
5. Colectomy