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Synkinesis

An involuntary movement accompanying a volitional movement. It often refers to facial movements that accompany FACIAL PARALYSIS.
Also Known As:
Synkineses
Networked: 129 relevant articles (13 outcomes, 10 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Facial Paralysis (Facial Palsy)
2. Paralysis (Palsy)
3. Hemifacial Spasm
4. Bell Palsy (Bell's Palsy)
5. Blepharospasm

Experts

1. Daly, Fergus: 6 articles (08/2015 - 01/2009)
2. Sullivan, Frank: 5 articles (08/2015 - 01/2009)
3. Gagyor, Ildiko: 4 articles (08/2015 - 01/2015)
4. Sullivan, Michael: 4 articles (08/2015 - 01/2015)
5. Somasundara, Dhruvashree: 4 articles (08/2015 - 01/2015)
6. Gammie, Fiona: 4 articles (08/2015 - 01/2015)
7. Madhok, Vishnu B: 4 articles (08/2015 - 01/2015)
8. Hadlock, Tessa A: 4 articles (01/2011 - 05/2007)
9. Salles, Alessandra Grassi: 2 articles (12/2015 - 11/2013)
10. Nduka, C: 2 articles (12/2015 - 07/2013)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Synkinesis:
1. Botulinum Toxins (Botulinum Toxin)IBA
2. Type A Botulinum Toxins (Botulinum A Toxin)FDA Link
3. Adrenal Cortex Hormones (Corticosteroids)IBA
01/01/2010 - "There was, also, a significant reduction in motor synkinesis during follow-up in those receiving corticosteroids (RR 0.6, 95% CI 0.44 to 0.81). "
09/02/2009 - "Meta-analysis using a random-effects model showed corticosteroids alone were associated with a reduced risk of unsatisfactory recovery (relative risk [RR], 0.69 [95% CI, 0.55-0.87]; P = .001) (number needed to treat to benefit 1 person, 11 [95% CI, 8-25]), a reduced risk of synkinesis and autonomic dysfunction (RR, 0.48 [95% CI, 0.36-0.65]; P < .001) (number needed to treat to benefit 1 person, 7 [95% CI, 6-10]), and no increase in adverse effects. "
01/01/2015 - "Motor synkinesis or crocodile tearsIn two trials comparing antivirals and corticosteroids with corticosteroids and placebo that assessed this outcome, we found a significant difference in long-term sequelae in favour of antivirals plus corticosteroids (RR 0.56, 95% CI 0.36 to 0.87, n = 469). "
01/01/2015 - "Motor synkinesis or crocodile tearsIn three trials comparing antivirals and corticosteroids with corticosteroids and placebo that assessed this outcome, we found a significant difference in long-term sequelae in favour of antivirals plus corticosteroids (RR 0.73, 95% CI 0.54 to 0.99, n = 869). "
01/01/2015 - "Motor synkinesis or crocodile tearsIn three trials comparing antivirals and corticosteroids with corticosteroids and placebo that assessed this outcome, we found a significant difference in long-term sequelae in favour or antivirals plus corticosteroids (RR 0.73, 95% CI 0.54 to 0.99, n = 869). "
4. MagnesiumIBA
5. ElectrolytesIBA
6. Antiviral Agents (Antivirals)IBA
01/01/2015 - "Motor synkinesis or crocodile tearsIn two trials comparing antivirals and corticosteroids with corticosteroids and placebo that assessed this outcome, we found a significant difference in long-term sequelae in favour of antivirals plus corticosteroids (RR 0.56, 95% CI 0.36 to 0.87, n = 469). "
01/01/2015 - "Motor synkinesis or crocodile tearsIn three trials comparing antivirals and corticosteroids with corticosteroids and placebo that assessed this outcome, we found a significant difference in long-term sequelae in favour of antivirals plus corticosteroids (RR 0.73, 95% CI 0.54 to 0.99, n = 869). "
01/01/2015 - "Motor synkinesis or crocodile tearsIn three trials comparing antivirals and corticosteroids with corticosteroids and placebo that assessed this outcome, we found a significant difference in long-term sequelae in favour or antivirals plus corticosteroids (RR 0.73, 95% CI 0.54 to 0.99, n = 869). "
09/02/2009 - "Eligible studies were randomized controlled trials comparing treatment with either corticosteroids or antiviral agents with a control and measuring at least 1 of the following outcomes: unsatisfactory facial recovery (> or = 4 months), unsatisfactory short-term recovery (6 weeks to < 4 months), synkinesis and autonomic dysfunction, or adverse effects. "
01/01/2009 - "In meta-analyses with some unexplained heterogeneity, the outcome with antivirals was significantly worse than with corticosteroids (n = 768, RR 2.82, 95% CI 1.09 to 7.32) and the outcome with antivirals plus corticosteroids was significantly better than with placebo (n = 658, RR 0.56, 95% CI 0.41 to 0.76).Motor synkinesis or crocodile tears at one year. "
7. onabotulinumtoxinA (Botox)FDA Link
8. Nerve Growth Factors (Neurotrophins)IBA
9. Marcus Gunn phenomenonIBA
10. Carbon MonoxideIBA

Therapies and Procedures

1. Psychology Biofeedback (Biofeedback)
2. Injections
3. Nerve Transfer
4. Exercise Therapy (Therapy, Exercise)
5. Denervation