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CADASIL

A familial, cerebral arteriopathy mapped to chromosome 19q12, and characterized by the presence of granular deposits in small CEREBRAL ARTERIES producing ischemic STROKE; PSEUDOBULBAR PALSY; and multiple subcortical infarcts (CEREBRAL INFARCTION). CADASIL is an acronym for Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy. CADASIL differs from BINSWANGER DISEASE by the presence of MIGRAINE WITH AURA and usually by the lack of history of arterial HYPERTENSION. (From Bradley et al, Neurology in Clinical Practice, 2000, p1146)
Also Known As:
CADASILM; Cerebral Arteriopathy with Subcortical Infarcts and Leukoencephalopathy; Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy; Dementia, Hereditary Multi-Infarct Type; Dementia, Hereditary Multi Infarct Type
Networked: 354 relevant articles (8 outcomes, 36 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. CADASIL
2. Migraine Disorders (Migraine)
3. Stroke (Strokes)
4. Dementia (Dementias)
5. Alzheimer Disease (Alzheimer's Disease)

Experts

1. Dichgans, Martin: 38 articles (08/2015 - 01/2002)
2. Chabriat, Hugues: 28 articles (08/2015 - 12/2002)
3. Jouvent, Eric: 19 articles (01/2015 - 08/2008)
4. Duering, Marco: 17 articles (06/2015 - 06/2009)
5. Dotti, Maria Teresa: 17 articles (10/2014 - 04/2004)
6. Federico, Antonio: 17 articles (10/2014 - 04/2004)
7. Kalimo, Hannu: 15 articles (09/2014 - 05/2004)
8. Opherk, Christian: 14 articles (03/2015 - 07/2004)
9. Joutel, Anne: 13 articles (02/2015 - 02/2004)
10. Viitanen, Matti: 13 articles (09/2014 - 05/2004)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to CADASIL:
1. glucuronyl glucosamine glycan sulfate (Vessel)IBA
2. CEREIBA
3. Acetazolamide (Diamox)FDA LinkGeneric
4. KB 2796 (lomerizine)IBA
5. Fibrinolytic Agents (Antithrombotic Agents)IBA
6. Adenosine Triphosphate (ATP)IBA
7. atorvastatin (Lipitor)FDA Link
8. technetium Tc 99m bicisate (Neurolite)FDA Link
9. Retinaldehyde (Retinal)IBA
10. Epidermal Growth Factor (EGF)IBA

Therapies and Procedures

1. Activities of Daily Living (ADL)
03/01/2014 - "After 21 months of follow-up, deterioration in her cognition and ability to perform instrumental activities of daily living were significant with a follow-up AD8 score of 7. Ascertain Dementia 8 questionnaire is an easy and valid screening tool for early cognitive impairment in patients with CADASIL syndrome."
01/01/2014 - "After adjustment for age, more CADASIL patients were disabled (impaired on ≥ 2 items of the Instrumental Activities of Daily Living scale) in comparison with ARL patients, and CADASIL patients had worse functional performances evaluated with the Disability Assessment for Dementia (DAD) scale. "
01/01/2015 - "Current evidence shows that the efficacy on cognitive function and activities of daily living of cholinesterase inhibitors in people with HD, CADASIL, MS, PSP or FTD is unclear, although cholinesterase inhibitors are associated with more gastrointestinal side effects compared with placebo."
01/01/2015 - "However, the treatment effect on other aspects of cognitive change were unclear, measured by the Selective Reminding Test (3 studies, WMD 1.47, 95% CI -0.39 to 3.32, P = 0.12; high quality evidence), patient's self-reported impression of memory change (2 studies, OR 1.67, 95% CI 0.93 to 3.00, P = 0.08; high quality evidence) and cognitive change (1 study, OR 0.95, 95% CI 0.45 to 1.98, P = 0.89; high quality evidence), clinician's impression of memory change (1 study, OR 1.50, 95% CI 0.59 to 3.84, P = 0.39; moderate quality evidence), other psychometric tests, and activities of daily living - patient reported impact of multiple sclerosis activities (1 study, WMD -1.18, 95% CI -3.02 to 0.66, P = 0.21; low quality evidence).One study on patients with CADASIL found a beneficial effect of cholinesterase inhibitors on the Executive interview, and Trail Making Test parts A and B. "
2. Flowmeters
3. Lasers (Laser)
4. Intravenous Injections
5. Anesthesia