Fetal Therapies (Fetal Therapy)

Prenatal interventions to correct fetal anomalies or treat FETAL DISEASES in utero. Fetal therapies include several major areas, such as open surgery; FETOSCOPY; pharmacological therapy; INTRAUTERINE TRANSFUSION; STEM CELL TRANSPLANTATION; and GENETIC THERAPY.

Also Known As:

Networked: 207 relevant articles (9 outcomes, 13 trials/studies)

Relationship Network

Therapy Context: Research Results

Experts

1.	Deprest, Jan: 11 articles (09/2022 - 04/2006)
2.	Ryan, Greg: 9 articles (03/2022 - 10/2017)
3.	Johnson, Anthony: 8 articles (03/2022 - 02/2011)
4.	Van Mieghem, Tim: 8 articles (12/2020 - 12/2006)
5.	Oepkes, Dick: 7 articles (01/2019 - 07/2011)
6.	Ruano, Rodrigo: 6 articles (03/2022 - 01/2019)
7.	Kilby, Mark D: 6 articles (01/2021 - 06/2005)
8.	Lopriore, Enrico: 6 articles (01/2019 - 07/2011)
9.	Moon-Grady, Anita J: 5 articles (01/2022 - 05/2014)
10.	Szaflik, Krzysztof: 5 articles (01/2017 - 05/2013)

Related Diseases

1.	Hydrops Fetalis (Fetal Edema) 01/01/2018 - "Published literature was retrieved through searches of PubMed or MEDLINE, CINAHL, and The Cochrane Library in 2017 using key words (non-immune hydrops fetalis, fetal hydrops, fetal therapy, fetal metabolism). " 01/01/2018 - "DONNéES: La littérature publiée a été récupérée au moyen de recherches menées dans PubMed, MEDLINE, CINAHL, et la Bibliothèque Cochrane en 2017 à l'aide de mots-clés (« non-immune hydrops fetalis », « fetal hydrops », « fetal therapy », « fetal metabolism »). " 09/01/1999 - "This report suggests that direct fetal therapy by umbilical vein puncture and evacuation of effusions constitutes an effective treatment for supraventricular tachycardias with massive fetal hydrops which do not respond to transplacental treatment." 07/01/2011 - "In the small group of fetuses in which the prognosis is poor, almost exclusively those with concomitant fetal hydrops and cardiac failure, several options for fetal therapy exist, often with a more than 50% survival rate. " 07/01/2008 - "When fetal hydrops is present or impending, in utero fetal therapy is required to try to reverse that pathological course associated with fetal or neonatal death. "
2.	Fetofetal Transfusion (Twin Transfusion Syndrome) 12/01/2006 - "The outcome of a randomized clinical trial demonstrating that fetoscopic laser coagulation of chorionic plate vessels is the most effective treatment for twin-twin transfusion syndrome (TTTS) has revived interest in endoscopic fetal therapy. " 12/01/2023 - "Not only does the understanding of the monochorionic placenta lead to an understanding of the pathophysiology of the complications of monochorionic twins, but it also has led to the development of highly effective directed fetal therapy via fetoscopic laser coagulation used in twin-to-twin transfusion syndrome." 11/28/2023 - "In monochorionic diamniotic twin pregnancies requiring fetal therapy for twin-twin transfusion syndrome, routine use of cervical pessary did not reduce the rate of preterm delivery before 32 weeks." 01/01/2019 - "Eleven North American Fetal Therapy Network (NAFTNet) centers conducted a retrospective review of twin-twin transfusion syndrome patients who underwent laser photocoagulation. " 01/01/2019 - "North American Fetal Therapy Network: Timing of and indications for delivery following laser ablation for twin-twin transfusion syndrome."
3.	Congenital Diaphragmatic Hernias 03/01/1993 - "In addition to ECMO, pharmacologic therapy, fetal surgery, lobar transplant, and ventilatory management research show promising results for treatment of the infant with a congenital diaphragmatic hernia." 10/01/2005 - "But we found the main relevant articles in Pubmed database, mainly published in Journal Pediatric Surgery and with some clusters of investigation (Congenital Diaphragmatic Hernia Study Group in Texas University and Buffalo Institute of Fetal Therapy in New York University). " 01/01/2023 - "Mortality prediction of congenital diaphragmatic hernia (CDH) is essential for developing treatment strategies, including fetal therapy. " 03/01/2022 - "To evaluate inter-rater agreement for sonographic classification of stomach position (as a surrogate for liver herniation) in fetal left congenital diaphragmatic hernia (LCDH) among: (i) fetal medicine specialists from the North American Fetal Therapy Network (NAFTNet) centers within and without the fetal endoscopic tracheal occlusion (FETO) consortium and in comparison to an expert external reviewer (ER1); and (iii) among two expert ERs (ER1 and ER2). " 01/01/2022 - "Congenital Diaphragmatic Hernia: Fetal Therapies to Increase Survival Are Only the Beginning."
4.	Meningomyelocele (Myelomeningocele) 01/01/2017 - "The Management of Myelomeningocele Study (MOMS Trial) has inspired many fetal therapy centers (FTCs) to offer open fetal surgery for myelomeningocele (MMC). " 01/01/2017 - "Fetal Therapy Model of Myelomeningocele with Three-Dimensional Skin Using Amniotic Fluid Cell-Derived Induced Pluripotent Stem Cells." 01/01/2015 - "For the time being, conclusive scientific evidence of the efficacy of invasive fetal therapies is available only for the twin-to-twin transfusion syndrome and fetal meningomyelocele." 04/01/2004 - "Of utility to a much smaller number of patients, invasive fetal therapy for meningomyelocele repair, twin-to-twin transfusion syndrome and fetal cardiac malformations is being evaluated in a scientifically more rigorous manner."
5.	Renal Insufficiency (Renal Failure) 05/01/2021 - "Serial amnioinfusions have shown promise in cases of EPRA due to CoBRA or renal failure and this treatment modality forms the basis of the ongoing NIH funded RAFT (Renal Anhydramnios Fetal Therapy) trial. " 09/01/1984 - "Hydramnios and maternal renal failure: relief with fetal therapy."

Related Drugs and Biologics

1.	Amiodarone (Amiodarona)
2.	Thyroid Hormones
3.	Immunoglobulins (Immunoglobulin)
4.	boldenone undecylenate (Equipoise)
5.	Digoxin (Digitek)
6.	Picibanil
7.	Sirolimus (Rapamycin)
8.	Azithromycin (Zithromax)
9.	Intravenous Immunoglobulins (IVIG)
10.	Spiramycin

Related Therapies and Procedures

1.	Laser Coagulation
2.	Punctures
3.	Injections
4.	Decompression
5.	Therapeutics