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Furin

A proprotein convertase with specificity for the proproteins of PROALBUMIN; COMPLEMENT 3C; and VON WILLEBRAND FACTOR. It has specificity for cleavage near paired ARGININE residues that are separated by two amino acids.

Also Known As:

Furin Protein; Paired Basic Amino Acid Cleaving Enzyme; SPC1 Proteinase; Processing Enzyme, Dibasic; Dibasic Processing Enzyme

Networked: 182 relevant articles (4 outcomes, 13 trials/studies) for this Bio-Agent, Comments

Relationship Network

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 24985
  - Hydrolases: 543
    - Peptide Hydrolases: 5704

Experts

1.	Seidah, Nabil G: 12 articles (01/2009 - 04/2003)
2.	Strongin, Alex Y: 7 articles (10/2009 - 03/2002)
3.	Bassi, Daniel E: 7 articles (08/2007 - 06/2002)
4.	Day, Robert: 5 articles (02/2010 - 03/2003)
5.	Khatib, Abdel-Majid: 5 articles (01/2009 - 04/2003)
6.	Basak, Ajoy: 5 articles (01/2009 - 06/2003)
7.	Chrétien, Michel: 5 articles (08/2008 - 04/2003)
8.	Stawowy, Philipp: 4 articles (03/2010 - 04/2005)
9.	Fleck, Eckart: 4 articles (03/2010 - 04/2005)
10.	Lindberg, Iris: 4 articles (02/2010 - 07/2003)

Related Diseases

1.	Infection 11/15/2007 - "Thus, furin inhibitors are unlikely to be effective in the treatment of filoviral infections." 03/01/2003 - "Studies of unprocessed virus produced in FD11 cells (wt/p62) demonstrated that the p62 protein was efficiently cleaved by purified furin in vitro, without requiring prior exposure to low pH. wt/p62 virus particles were also processed during their endocytic uptake in furin-containing cells, resulting in more efficient virus infection. " 01/01/2010 - "In cells deficient in S1P, the furin-dependent LCMV variant established persistent infection, whereas wild-type LCMV underwent extinction without the emergence of S1P-independent escape variants. " 09/01/2009 - "Here we demonstrate that healthy Han Chinese from southern China (an endemic area of HBV infection) harbor a common single nucleotide polymorphism (SNP; -229 C/T) in a 1268-bp region of the P1 promoter of the furin gene [FES upstream region (Fur)]. " 09/01/2009 - "Influence of a single nucleotide polymorphism in the P1 promoter of the furin gene on transcription activity and hepatitis B virus infection." Order ALL the reference details at left...
2.	Anthrax 04/01/2009 - "The results provide good prospect of using the proposed QSAR models for the rational design of novel therapeutic furin inhibitors toward anthrax and furin-dependent diseases." 01/01/2005 - "In addition, our study supports a unique role of furin in the activation of PA, thereby suggesting that furin inhibitors are the likely specific drugs for short-term therapy of anthrax infection." 05/01/2007 - "We used this system to monitor the Golgi-associated protease furin, a pluripotent enzyme with a key role in tumorigenesis, viral propagation of avian influenza, ebola, and HIV as well as in activation of anthrax, pseudomonas, and diphtheria toxins. " 01/01/2004 - "Recently, the involvement of furin in diseases ranging from Alzheimer's disease and cancer to anthrax and Ebola fever has created additional focus on proprotein processing. " 07/01/2003 - "Furin, the best-characterized member of the mammalian PC family, has essential functions in embryogenesis and homeostasis but is also implicated in various pathologies such as tumor metastasis, neurodegeneration and various bacterial and viral diseases caused by such pathogens as anthrax and pathogenic Ebola virus strains. " Order ALL the reference details at left...
3.	Human Influenza (Influenza) 07/15/2009 - "Interestingly, two amino acid substitutions on the prime side of the peptide derived from H5N1 influenza hemagglutinin furin processing site highly improved its hydrolysis. " 07/01/2008 - "The H5N1 influenza variant Fujian-like hemagglutinin selected following vaccination exhibits a compromised furin cleavage : neurological Consequences of highly pathogenic Fujian H5N1 strains." 09/29/1995 - "Also, the envelope proteins of viruses, such as influenza and HIV viruses, need to be processed by furin for infectivity. " 03/01/1999 - "In contrast to HIV envelope glycoproteins, the influenza hemagglutinin precursor (HA0), that is thought to be matured by the furin-like enzymes as well, is found to be retained within the cell and is not able to reach the cell surface. " 02/01/2001 - "Fluorogenic peptides encompassing the processing sites of envelope glycoproteins of the infectious influenza A Hong Kong virus (HKV), Ebola virus (EBOV) and respiratory syncytial virus (RSV) were tested for cleavage by soluble recombinants of the proprotein convertases furin, PC5 and PC7. " Order ALL the reference details at left...
4.	Poisoning 07/01/2009 - "To examine the implications of endosomal translocation in the intoxication process, we investigated whether the toxin required furin-mediated processing in order to kill cells. " 05/05/1995 - "To investigate the role of this cleavage for intoxication of cells, we studied the ability of unnicked and furin-nicked toxin to inhibit protein synthesis in LoVo/fur and LoVo/neo cells. " 05/25/2007 - "Cleavage of this site by furin is essential for rapid intoxication of cells by Shiga toxin. " 01/01/2001 - "During the process of intoxication, PA binds to the cell surface receptor and is cleaved at the sequence RKKR (167) by cell surface proteases such as furin generating a cell-bound, C-terminal 63 kDa protein (PA63). " 05/05/1995 - "The results suggest that cleavage of Shiga toxin is important for intoxication of cells, and they indicate that furin can cleave and thereby activate Shiga toxin in cells." Order ALL the reference details at left...
5.	AIDS-Related Complex (ARC) 06/01/1995 - "We also observed a significant reduction in ARC furin mRNA levels in old mice compared to either young or middle-aged mice. " 06/01/1995 - "By Northern blot analysis, a significant increase (P < 0.05) in ARC PC2 mRNA levels was detected in middle-aged compared to young mice, but ARC PC1 and furin mRNA levels were unaltered. " 06/01/1995 - "We compared ARC messenger RNA (mRNA) levels of PC1, PC2, and furin by Northern blot and in situ hybridization analyses in young, middle-aged, and old mice. " Order ALL the reference details at left...

Related Drugs and Biologics

1.	Hemagglutinins (Hemagglutinin)
2.	Proteins (Proteins, Gene)
3.	Messenger RNA (mRNA)
4.	inter-alpha-inhibitor
5.	Transforming Growth Factor beta (TGF-beta)
6.	tetrapeptide carbamate
7.	Enzymes
8.	Gelsolin
9.	Peptides
10.	Insulin (Novolin)

Related Therapies and Procedures

1.	Heterologous Transplantation (Xenotransplantation)
2.	Therapeutics

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