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Proprotein Convertase 1

A CALCIUM-dependent endopeptidase that has specificity for cleavage at ARGININE that is near paired basic residues. It cleaves a variety of prohormones including PRO-OPIOMELANOCORTIN; PRORENIN; proenkephalins; prodynorphin; prosomatostatin; and PROINSULIN.
Also Known As:
Neuroendocrine Convertase PC1; PC1 Endoprotease; PC3 Endoprotease; PC3 Prohormone Convertase; Prohormone Convertase 1; Prohormone Convertase 3; Prohormone Convertase, PC1; Proinsulin Convertase 1; Proprotein Convertase SPC3; Convertase 1, Proprotein; Convertase PC1, Neuroendocrine; Convertase SPC3, Proprotein; Convertase, PC1 Prohormone; Convertase, PC3 Prohormone; Endoprotease, PC1; Endoprotease, PC3; Prohormone Convertase, PC3; PC1 Prohormone Convertase
Networked: 47 relevant articles (0 outcomes, 5 trials/studies)

Bio-Agent Context: Research Results

Experts

1. Creemers, John W M: 4 articles (12/2014 - 11/2003)
2. Lindberg, Iris: 3 articles (07/2014 - 01/2013)
3. Farooqi, I Sadaf: 3 articles (09/2013 - 11/2003)
4. O'Rahilly, Stephen: 3 articles (09/2013 - 11/2003)
5. Stijnen, Pieter: 2 articles (12/2014 - 02/2012)
6. Gekakis, Nicholas: 2 articles (07/2014 - 06/2006)
7. Sokollik, Christiane: 2 articles (11/2013 - 07/2013)
8. Brubaker, Patricia L: 2 articles (11/2013 - 11/2003)
9. Avitzur, Yaron: 2 articles (11/2013 - 07/2013)
10. Van Hul, Wim: 2 articles (02/2012 - 01/2009)

Related Diseases

1. Neoplasms (Cancer)
2. Obesity
3. Type 2 Diabetes Mellitus (MODY)
4. Pituitary Neoplasms (Pituitary Adenoma)
5. Body Weight (Weight, Body)

Related Drugs and Biologics

1. Pro-Opiomelanocortin (Proopiomelanocortin)
2. Leptin
3. Messenger RNA (mRNA)
4. Proglucagon (Glucagon Precursors)
5. Incretins
6. Dipeptidyl Peptidase 4 (Dipeptidyl Peptidase IV)
7. Gastric Inhibitory Polypeptide (Glucose Dependent Insulinotropic Peptide)
8. Adrenocorticotropic Hormone (ACTH)
9. Leptin Receptors
10. Proprotein Convertase 2

Related Therapies and Procedures

1. Bariatric Surgery
2. Immunotherapy