|1.||Creemers, John W M: 4 articles (12/2014 - 11/2003)|
|2.||Lindberg, Iris: 3 articles (07/2014 - 01/2013)|
|3.||Farooqi, I Sadaf: 3 articles (09/2013 - 11/2003)|
|4.||O'Rahilly, Stephen: 3 articles (09/2013 - 11/2003)|
|5.||Stijnen, Pieter: 2 articles (12/2014 - 02/2012)|
|6.||Gekakis, Nicholas: 2 articles (07/2014 - 06/2006)|
|7.||Sokollik, Christiane: 2 articles (11/2013 - 07/2013)|
|8.||Brubaker, Patricia L: 2 articles (11/2013 - 11/2003)|
|9.||Avitzur, Yaron: 2 articles (11/2013 - 07/2013)|
|10.||Van Hul, Wim: 2 articles (02/2012 - 01/2009)|
11/01/2015 - "Molecular Consequences of Proprotein Convertase 1/3 (PC1/3) Inhibition in Macrophages for Application to Cancer Immunotherapy: A Proteomic Study."
12/01/2005 - "Immunohistochemical study revealed that immunoreactivity of proopiomelanocortin (POMC) was positive within the tumor cells, whereas those of ACTH and prohormone convertase 1/3 were negative. "
04/01/1999 - "Immunohistochemically the tumors showed expression of chromogranin A (all cases), chromogranin B (three cases), pancreastatin and chromostatin (four cases, respectively), prohormone convertase PC3 (three cases), carcinoembryonic antigen (CEA) and CA19-9 (two cases), cytokeratin 56 kDa (three cases), 160 kDa neurofilament (two cases) and neuron-specific enolase (two cases). "
07/01/2014 - "The genetics of obesity meets basic cell biology through prohormone convertase 1/3."
07/01/2014 - "Mutations in the PCSK1 gene encoding prohormone convertase 1/3 (PC1/3) are strongly associated with obesity in humans. "
09/01/2013 - "Non-synonymous mutations affecting both alleles of PCSK1 (proprotein convertase 1/3) are associated with obesity and impaired prohormone processing. "
08/01/2013 - "Until now, in prohormone convertase 1 deficient patients, low serum nesfatin-1 levels have not been mentioned to be a possible cause of obesity, we suggest that in these patients low levels of anorexigenic peptid nesfatin-1 might be another facilitating factor for development of obesity. "
08/01/2013 - "Low serum nesfatin-1 levels may be a contributing factor for monogenic obesity due to prohormone convertase 1 deficiency."
|3.||Type 2 Diabetes Mellitus (MODY)
07/01/1996 - "Human prohormone convertase 3 gene: exon-intron organization and molecular scanning for mutations in Japanese subjects with NIDDM."
02/01/1998 - "Prohormone convertase 1 in obesity, gestational diabetes mellitus, and NIDDM: no evidence for a major susceptibility role."
12/01/2014 - "The aim of this study was to investigate the messenger RNA (mRNA) gene expression of proglucagon, glucose-dependent insulinotropic peptide (GIP), prohormone convertase 1/3 (PC1/3), and dipeptidyl peptidase-IV (DPP-IV) in jejunum cells of the morbidly obese (OB) non type 2 diabetes mellitus (NDM2) and type 2 diabetes mellitus (T2DM), to determine the molecular basis of incretin secretion after bariatric surgery. "
|4.||Pituitary Neoplasms (Pituitary Adenoma)
|5.||Body Weight (Weight, Body)
09/01/2012 - "Prohormone convertase 1/3 was elevated at days 3 and 7. In hyperglycaemic rats, fasting blood glucose was lower at days 1, 3 and 7 but not thereafter, and body weight was maintained to day 28. "
03/01/2004 - "Taken together, these results are consistent with a role for proSAAS-derived peptides as neuropeptides that influence body weight independently of their function as inhibitors of prohormone convertase 1."
11/01/2007 - "Energy balance (body weight, energy intake and energy expenditure); sensitivity to central leptin and central alpha-melanin stimulating hormone (alpha-MSH) administration and expression levels of hypothalamic ObRb, signal transducers and activators of transcription factor (STAT)-3 phosphorylation, suppressor of cytokine signalling-3 (SOCS-3), proopiomelanocortin (POMC) processing hormones (prohormone convertase-1 and prohormone convertase-2) and neuropeptide Y (NPY) were measured. "
|3.||Messenger RNA (mRNA)
|4.||Proglucagon (Glucagon Precursors)
|6.||Dipeptidyl Peptidase 4 (Dipeptidyl Peptidase IV)
|7.||Gastric Inhibitory Polypeptide (Glucose Dependent Insulinotropic Peptide)
|8.||Adrenocorticotropic Hormone (ACTH)
|10.||Proprotein Convertase 2