|1.||Cheng, Bin: 3 articles (02/2010 - 06/2004)|
|2.||Osawa, Kayo: 3 articles (01/2010 - 01/2008)|
|3.||Miyaishi, Aiko: 3 articles (01/2010 - 01/2008)|
|4.||Takahashi, Juro: 3 articles (01/2010 - 01/2008)|
|5.||Tsutou, Akimitsu: 3 articles (01/2010 - 01/2008)|
|6.||Inoue, Natsuko: 3 articles (01/2010 - 01/2008)|
|7.||Osawa, Yasunori: 3 articles (01/2010 - 01/2008)|
|8.||Emanuele, Enzo: 2 articles (09/2015 - 03/2014)|
|9.||Moy, Ronald: 2 articles (03/2015 - 12/2010)|
|10.||Loeb, Lawrence A: 2 articles (08/2013 - 12/2003)|
11/15/2002 - "Identifying these genotypic alterations in DNA-repair enzymes and their association with cancer may help to elucidate the mechanisms of cancer etiology and to predict both disease risk and response to cancer therapy, since most antineoplastic treatments mediate their effects through DNA damage."
01/20/2015 - "Finally, the clock may affect the efficacy of cancer treatment (chronochemotherapy) by modulating the pharmacokinetics and pharmacodynamics of chemotherapeutic drugs as well as the activity of the DNA repair enzymes that repair the DNA damage caused by anticancer drugs. "
07/01/2005 - "tumor suppressor and oncogenes; lack of evidence that the oxidative lesions induce mutations in vivo; no cancer development in animals knocked-out for specific DNA repair enzymes in spite of high tissue levels of oxidative lesions; and unchanged cancer rates after antioxidant interventions in large clinical controlled and randomized trials. "
05/01/2015 - "Such resistance is partly due to the ability of cancer cells to use a variety of DNA repair enzymes to maintain cell viability. "
05/01/2014 - "Therefore, suppression of the activity of critical DNA repair enzymes in tumor cells is considered one of the promising directions to overcome this resistance. "
01/01/2012 - "Our results are the first to report that mtDNA damage is the proximal cause in palmitate-induced mitochondrial dysfunction and impaired insulin signaling and provide strong evidence that targeting DNA repair enzymes into mitochondria in skeletal muscles could be a potential therapeutic treatment for insulin resistance."
|3.||Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
08/15/2007 - "The aim of this study was to determine the relationship between expression status of DNA repair enzymes and chemosensitivity in patients with non-small cell lung cancer (NSCLC). "
02/01/2011 - "To study the expression of heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) in non-small cell lung cancer (NSCLC), and the interaction between hnRNP A2/B1 protein and mRNA of DNA repair enzymes O(6)-methylguanine DNA-methyltransferase (MGMT), 8-oxoguanine DNA glycosylase (OGG1), redox factor 1(Ref-1), DNA-dependent protein kinase (including DNA-PKcs and ku). "
|4.||Lung Neoplasms (Lung Cancer)
01/01/2009 - "Genetic polymorphisms of DNA repair enzymes in the base excision repair (BER) pathway, may lead to genetic instability and lung cancer carcinogenesis. "
12/01/2007 - "We hypothesized that genetic variants in DNA repair and cell cycle control pathways will influence the predisposition to lung cancer, and studied 27 variants in 17 DNA repair enzymes and 10 variants in eight cell cycle control genes in 1,604 lung cancer patients and 2,053 controls. "
05/01/2005 - "These data also suggest that individuals with impaired DNA repair enzymes might be more susceptible to lung cancer induced by 1-NP."
09/01/2004 - "Impact of genetic polymorphisms in DNA repair enzymes on drug resistance in lung cancer."
05/01/2006 - "Case-control studies of genetic polymorphisms in DNA repair enzymes suggest that the common variant Ser326Cys in OGG1 may be a risk factor for lung cancer, whereas a rare variant in OGG1 and germ line mutations in the corresponding mismatch repair gene MYH are risk factors for hereditary colon cancer. "
|5.||Hepatocellular Carcinoma (Hepatoma)
04/01/2009 - "To observe the alteration in the expression of DNA repair enzymes hOGG1 and hMYHalpha and the change in 8-OHdG levels in the HBx gene-transfected cells HepG2/HBx and to explore the mechanisms of the HBV-associated hepatocellular carcinoma, the gene-transfected cells HepG2/HBx which stably expressed HBx was established, and the effect of HBx on the cell cycle and proliferation of HepG2 was examined. "
06/01/2004 - "The aim of this study was to evaluate the extent of oxidative damage and its dependence on the cellular antioxidative capacity and the expression of specific DNA repair enzymes in tumor (tu) and corresponding adjacent nontumor (ntu) liver tissue of 23 patients with histologically confirmed hepatocellular carcinoma. "
02/01/2005 - "Hepatocellular carcinoma and polymorphisms in carcinogen-metabolizing and DNA repair enzymes in a population with aflatoxin exposure and hepatitis B virus endemicity."
|2.||Poly Adenosine Diphosphate Ribose
|4.||Mitochondrial DNA (mtDNA)
|6.||Sunscreening Agents (Sunscreens)
|7.||Messenger RNA (mRNA)
|8.||DNA (Deoxyribonucleic Acid)
|10.||Intercellular Signaling Peptides and Proteins (Growth Factors)
|1.||Drug Therapy (Chemotherapy)