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Flap Endonucleases

Endonucleases that remove 5' DNA sequences from a DNA structure called a DNA flap. The DNA flap structure occurs in double-stranded DNA containing a single-stranded break where the 5' portion of the downstream strand is too long and overlaps the 3' end of the upstream strand. Flap endonucleases cleave the downstream strand of the overlap flap structure precisely after the first base-paired nucleotide, creating a ligatable nick.
Also Known As:
FEN-1; Fen1 Protein; Flap Endonuclease-1; RAD2 Homolog-1 Nuclease; RTH-1 Nuclease; Endonuclease-1, Flap; Endonucleases, Flap; Flap Endonuclease 1; Nuclease, RTH-1; RAD2 Homolog 1 Nuclease; RTH 1 Nuclease
Networked: 43 relevant articles (0 outcomes, 4 trials/studies)

Bio-Agent Context: Research Results

Experts

1. Shen, Binghui: 7 articles (01/2015 - 01/2005)
2. Zheng, Li: 5 articles (01/2015 - 01/2005)
3. Madhusudan, Srinivasan: 3 articles (12/2014 - 06/2013)
4. Dai, Huifang: 3 articles (07/2011 - 07/2008)
5. Zhou, Mian: 3 articles (07/2011 - 01/2005)
6. Sommers, Joshua A: 3 articles (01/2005 - 10/2002)
7. Brosh, Robert M: 3 articles (01/2005 - 10/2002)
8. Dai, H: 2 articles (02/2015 - 03/2011)
9. Zheng, L: 2 articles (02/2015 - 03/2011)
10. Shen, B: 2 articles (02/2015 - 03/2011)

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5. Myotonic Dystrophy (Dystrophia Myotonica)

Related Drugs and Biologics

1. Proteins (Proteins, Gene)
2. Uracil-DNA Glycosidase
3. Exonucleases (3' 5' Exonuclease)
4. N-(chloroacetyl)glutamate
5. Flap Endonucleases
6. DNA (Deoxyribonucleic Acid)
7. Proliferating Cell Nuclear Antigen (PCNA)
8. Antigens
9. DNA-Activated Protein Kinase
10. A-Form DNA (A-DNA)