Holliday Junction Resolvases

Enzymes that recognize CRUCIFORM DNA structures and introduce paired incisions that help to resolve the structure into two DNA helices.

Also Known As:

Cruciform Cutting Endonuclease; Cruciform DNA Resolving Endonuclease; Endonuclease, Cruciform Cutting; Resolvase, Holliday Junction; Holliday Junction Resolvase; Resolvases, Holliday Junction

Networked: 11 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Hydrolases: 2166
    - Esterases: 1574
      - Deoxyribonucleases: 1259
        Endodeoxyribonucleases
        Holliday Junction Resolvases: 11
        Arabidopsis SEND1 protein
        Arabidopsis TRICHOME BIREFRINGENCE-LIKE27 protein
        Arabidopsis XPG-like endonuclease 1
        E coli RusA protein
        human GEN1 protein
        mouse GEN1 protein
        S cerevisiae CCE1 protein
        S cerevisiae Yen1 protein
      - Endonucleases: 1227
        Endodeoxyribonucleases
        Holliday Junction Resolvases: 11
        Arabidopsis SEND1 protein
        Arabidopsis TRICHOME BIREFRINGENCE-LIKE27 protein
        Arabidopsis XPG-like endonuclease 1
        E coli RusA protein
        human GEN1 protein
        mouse GEN1 protein
        S cerevisiae CCE1 protein
        S cerevisiae Yen1 protein
  - Recombinases: 454
    - Holliday Junction Resolvases: 11

Experts

1.	Shen, Qian: 2 articles (03/2019 - 01/2018)
2.	Wang, Herui: 2 articles (03/2019 - 01/2018)
3.	Wang, Xiaowen: 2 articles (03/2019 - 01/2018)
4.	Wu, Xiaohui: 2 articles (03/2019 - 01/2018)
5.	Xu, Hong: 2 articles (03/2019 - 01/2018)
6.	Carvajal-Garcia, Juan: 1 article (01/2021)
7.	Crown, K Nicole: 1 article (01/2021)
8.	Ramsden, Dale A: 1 article (01/2021)
9.	Sekelsky, Jeff: 1 article (01/2021)
10.	Zhang, Xin: 1 article (03/2019)

Related Diseases

1.	Vesico-Ureteral Reflux (Vesicoureteral Reflux) 01/01/2018 - "In this study, we report that disruption of the Holliday Junction resolvase gene Gen1 leads to renal agenesis, duplex kidney, hydronephrosis, and vesicoureteral reflux (VUR) in mice. "
2.	Hydronephrosis 01/01/2018 - "In this study, we report that disruption of the Holliday Junction resolvase gene Gen1 leads to renal agenesis, duplex kidney, hydronephrosis, and vesicoureteral reflux (VUR) in mice. "
3.	Hereditary renal agenesis 01/01/2018 - "In this study, we report that disruption of the Holliday Junction resolvase gene Gen1 leads to renal agenesis, duplex kidney, hydronephrosis, and vesicoureteral reflux (VUR) in mice. "
4.	Genomic Instability 01/01/2021 - "Our work argues that Pol θ can thus compensate for the loss of the Holliday junction resolvases by using homologous recombination intermediates, suppressing mitotic crossing over and preserving the genomic stability of cells." 09/11/2014 - "Spatial control of the GEN1 Holliday junction resolvase ensures genome stability." 04/10/2014 - "The Cdk/cDc14 module controls activation of the Yen1 holliday junction resolvase to promote genome stability."
5.	Hypersensitivity (Allergy) 09/06/2002 - "Accordingly, we show that the hypersensitivity to agents that cause replication fork stalling of mus81, eme1, and rqh1 mutants is suppressed by a Holliday junction resolvase (RusA), as is the synthetic lethality of a mus81(-) rqh1(-) double mutant. " 09/01/2011 - "Here, we examine the basis of hypersensitivity to thymine deprivation (hyper-TLD) in mutants that lack the UvrD helicase, which opposes RecA action and participates in some DNA repair mechanisms, RecBCD exonuclease, which degrades double-stranded linear DNA and works with RecA in double-strand-break repair and SOS induction, and RuvABC Holliday-junction resolvase. "

Related Drugs and Biologics

1.	Thymine
2.	Proteins (Proteins, Gene)
3.	Exonucleases (3' 5' Exonuclease)
4.	DNA (Deoxyribonucleic Acid)
5.	Epitopes