Microbubbles

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468 relevant articles (19 outcomes, 60 trials/studies) found for this Therapy

Description: Very small encapsulated gas bubbles (diameters of micrometers) that can be used as CONTRAST MEDIA, and in other diagnostic and therapeutic applications. Upon exposure to sufficiently intense ultrasound, microbubbles will cavitate, rupture, disappear, release gas content, etc. Such characteristics of the microbubbles can be used to enhance diagnostic tests, dissolve blood clots, and deliver drugs or genes for therapy.

Also Known As:

Colloidal Gas Aphrons; Aphron, Colloidal Gas; Aphrons, Colloidal Gas; Colloidal Gas Aphron; Gas Aphron, Colloidal; Gas Aphrons, Colloidal; Microbubble

Relationship Network

Therapy Context: Research Results

Equipment and Supplies

Microbubbles: 468

Experts

1.	Klibanov, Alexander L: 5 articles (05/2008 - 11/2002)
2.	Xie, Feng: 4 articles (08/2005 - 07/2003)
3.	Porter, Thomas R: 4 articles (08/2005 - 07/2003)
4.	Ley, K: 4 articles (10/2001 - 02/2000)
5.	Lindner, J R: 4 articles (10/2001 - 02/2000)
6.	Blomley, M J K: 3 articles (08/2006 - 08/2003)
7.	Eckersley, R J: 3 articles (01/2005 - 03/2000)
8.	Cosgrove, D O: 3 articles (01/2005 - 03/2000)
9.	Morishita, Ryuichi: 3 articles (04/2004 - 06/2003)
10.	Song, J: 3 articles (10/2001 - 08/2000)

Related Diseases

1.	Neoplasms (Cancer) 07/01/2003 - "CONCLUSION: Although the injection of a microbubble agent improved the sensitivity of the method detecting vascularization of tumors, a positive finding for vascularization by this method was not clinically useful in the differentiation of benign and malignant ovarian tumors." 02/01/2008 - "The purpose of this study was to determine and compare the blood volume of tumor tissue measured noninvasively by MRI and microbubble contrast ultrasound imaging" 12/01/2007 - "This study investigated whether a microbubble-containing ultrasound contrast agent had a role in the antivascular action of physiotherapy ultrasound on tumor neovasculature" 06/01/2007 - "OBJECTIVE: The purpose of this study was to evaluate the ability of dynamic microbubble contrast-enhanced sonography (MCES), in comparison with dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and fluorodeoxyglucose positron emission tomography (FDG-PET), to quantitatively characterize tumor perfusion in implanted murine tumors before and after treatment with a variety of regimens" 06/01/2007 - "This study firstly examined the antitumor effect of angiogenesis inhibitor combined with ultrasound (US) irradiation for human cancer in vivo and evaluated its vascularity using color Doppler US in real time with a microbubble US contrast agent" Get all the results and reference details, order at left...
2.	Inflammation 09/12/2006 - "In a murine cremaster inflammation model, a significant improvement of deformable microbubble targeting was observed by intravital microscopy" 04/01/2008 - "Angiogenesis, inflammation, and other endothelial dysfunctions are important targets that can be imaged and investigated with targeted microbubbles" 08/01/2005 - "It also appeared that microbubble-enhanced US exposure itself did not affect inflammation" 03/01/2005 - "In this review, we present new information suggesting that microbubble contrast-enhanced IVUS can measure activity and inflammation within atherosclerotic plaques by imaging vasa vasorum density" 05/01/2003 - "Recently it has been suggested this technique is capable of detecting microvascular injury and inflammation because sonicated albumin microbubbles adhere to activated neutrophils and, in the presence of denuded or inflamed endothelium, they persist within the microvasculature rather than passing unimpeded, which results in profound slowing of their transit rates" Get all the results and reference details, order at left...
3.	Fibrosis (Cirrhosis) 10/01/2007 - "In rats transfected with a Smad7 transgene using an ultrasound-microbubble-mediated system, peritoneal fibrosis was attenuated, peritoneal function was improved, and Smad2/3 activation was inhibited" 12/01/2007 - "OBJECTIVE: The purpose of this study was to assess the diagnostic value of hepatocellular nodule vascularity after microbubble injection for characterization of malignancy in patients with cirrhosis of the liver" 10/01/2005 - "Disturbance of microbubble accumulation was correlated with sinusoidal function rather than morphological changes such as fibrosis and parenchymatitis in the animal studies" 12/01/2007 - "Diagnostic value of hepatocellular nodule vascularity after microbubble injection for characterizing malignancy in patients with cirrhosis." 01/01/2007 - "HA-HVTT and the PSI difference of the microbubble perfusion in liver parenchyma and PV were considered to differentiate the degree of hepatic fibrosis between F4 and other early stages." Get all the results and reference details, order at left...
4.	Adhesions 09/12/2006 - "We hypothesized that targeted delivery could be improved further, by making the microbubbles deformable, leading to increased microbubble-endothelium adhesion contact area and stabilized adhesion" 05/01/2008 - "During in vitro studies, radiation force enhanced microbubble adhesion up to 60-fold" 10/06/2008 - "Adhesion and ultrasound-induced delivery from monodisperse microbubbles in a parallel plate flow cell." 02/01/2008 - "Here, we extend previous work on a stimulus-responsive microbubble construct, in which the ligand is normally buried by a polymeric overbrush and transiently revealed by ultrasound radiation force, to show reduced complement activation and focused adhesion to cells using a physiological peptide ligand" 11/01/2007 - "Atomic force microscopy (AFM) is a versatile mechanical nanosensor that can be used to quantify the mechanical properties of microbubbles (MBs) and the adhesion mechanisms of targeted MBs" Get all the results and reference details, order at left...
5.	Neoplasm Metastasis (Metastasis) 03/04/2000 - "Pulse-inversion mode imaging of liver specific microbubbles: improved detection of subcentimetre metastases." 12/01/2006 - "Microbubbles linger in the extensive sinusoidal space of normal liver for several minutes whereas they wash out rapidly from metastases, which have a low vascular volume and thus appear as filling defects" 06/01/1999 - "Radio-frequency ablation of hepatic metastases: postprocedural assessment with a US microbubble contrast agent--early experience." 08/01/2006 - "Microbubble ultrasound: how can it help detect melanoma metastasis?" 07/01/2004 - "Microbubbles also can be used as tracers to provide functional information that can detect occult metastases and cirrhosis noninvasively." Get all the results and reference details, order at left...
159 Diseases and 468 more articles analyzed in the Research Interface, order at left...

Related Drugs and Biologics

1.	Contrast Media
2.	Carbon Dioxide
3.	contrast agent BR1
4.	FS 069 (Optison)
5.	DNA (Deoxyribonucleic Acid)
6.	Transforming Growth Factor beta (TGF-beta)
7.	Doxycycline (Vibramycin)
8.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
9.	P-Selectin
10.	Fibrinolytic Agents (Antithrombotic Agents)
114 Drugs and Important Bio-Agents and 188 more articles analyzed in the Research Interface, order at left...

Related Therapies and Procedures

1.	Microbubbles
2.	Decompression
3.	Cardiopulmonary Bypass (Heart-Lung Bypass)
4.	Aftercare (After-Treatment)
5.	Liquid Ventilation
24 Therapies and Procedures and 40 more articles analyzed in the Research Interface, order at left...

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