Pregnancy-Associated alpha 2-Macroglobulins (alpha 2 Macroglobulin)
Large (>160 kDa) glycoproteins with electrophoretic mobility of ALPHA-GLOBULINS, found in high concentration in the plasma of pregnant women but also in a number of species including mouse, rat, and others (ALPHA-MACROGLOBULINS). In humans, they are always present in the circulation and are nonspecific inhibitors of PROTEINASES, similar to COMPLEMENT PROTEINS (C3; C4; C5).
Also Known As:
alpha 2 Macroglobulin; PAAG; alpha2 Macroglobulin; alpha 2-Glucoprotein; alpha 2-Macroglobulin; alpha(2)-PAG; alpha2-Macroglobulin; alpha2-PAG; Pregnancy Associated alpha 2 Globulins; Pregnancy Associated alpha 2 Glycoproteins; Pregnancy Associated alpha 2 Macroglobulins; alpha 2 Glucoprotein; alpha 2 Glucoproteins; alpha 2-Globulins, Pregnancy-Associated; alpha 2-Glycoproteins, Pregnancy-Associated; alpha 2-Macroglobulins, Pregnancy-Associated; alpha2 PAG; Pregnancy-Associated alpha 2-Globulins; Pregnancy-Associated alpha 2-Glycoproteins; alpha 2-Glucoproteins
Networked: 992
relevant articles (22 outcomes,
91 trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Experts
1. | Birkenmeier, Gerd:
5 articles
(01/2017 - 12/2003)
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2. | Akahoshi, Tohru:
5 articles
(01/2012 - 01/2008)
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3. | Kanoh, Yuhsaku:
5 articles
(01/2012 - 01/2008)
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4. | Narayanaswamy, Vidya P:
4 articles
(01/2022 - 01/2017)
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5. | Townsend, Stacy M:
4 articles
(01/2022 - 01/2017)
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6. | Huse, Klaus:
4 articles
(01/2017 - 09/2004)
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7. | Cheng, Ning-Xin:
4 articles
(06/2011 - 09/2002)
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8. | Andersson, Morgan:
4 articles
(02/2010 - 10/2002)
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9. | Greiff, Lennart:
4 articles
(02/2010 - 10/2002)
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10. | Imbert-Bismut, Françoise:
4 articles
(10/2007 - 01/2003)
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Related Diseases
1. | Inflammation (Inflammations)
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2. | Neoplasms (Cancer)
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3. | Rheumatoid Arthritis
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4. | Proteinuria
01/01/1975
- " In 58 of the examined patients, proteinuria selectivity is determined simultaneously and by the JgG clearance and trasferrin-accoringing to the method of Cameron et al. (with immunodiffused plaques) and immunoelectrophoresis and by the clearance of alpha2-macroglobulin and transferrin. " 12/01/1998
- " In post-renal proteinuria, alpha2-macroglobulin proved to be a useful marker, when albumin excretion exceeds 100 mg/l urine. " 12/01/1998
- " Proteinuria selectivity index based upon alpha 2-macroglobulin or IgM is superior to the IgG based index in differentiating glomerular diseases. " 01/01/1977
- " Though the fetus was macroscopically normal, measurement of albumin, alpha-FP, IgG, and alpha2-macroglobulin in the fetal urine showed a selective proteinuria, and congenital nephrosis was diagnosed after examination of the fetal kidneys by electron microscopy. " 03/01/2004
- " By analyzing albumin, alpha1-microglobulin, immunoglobulin G and alpha2-macroglobulin, together with total protein in urine, it is possible to detect and differentiate causes of prerenal, renal (glomerular, tubular, glomerulo-tubular) and postrenal proteinuria. "
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5. | Infections
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