Phospho-Specific Antibodies

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40 relevant articles (0 outcomes, 2 trials/studies) found for this Bio-Agent

Description: Antibodies directed against immunogen-coupled phosphorylated PEPTIDES corresponding to amino acids surrounding the PHOSPHORYLATION site. They are used to study proteins involved in SIGNAL TRANSDUCTION pathways. (From Methods Mol Biol 2000; 99:177-89)

Also Known As:

Antibodies, Phospho-Specific; Phosphospecific Antibody; Antibodies, Antiphosphopeptide Specific; Antibodies, Phospho Specific; Antibodies, Phosphopeptide Specific; Antibodies, Phosphorylation State-Specific; Antibody, Phosphospecific; Antiphosphopeptide-Specific Antibodies; Phospho Specific Antibodies; Phosphopeptide Specific Antibodies; Phosphorylation State Specific Antibodies; State-Specific Antibodies, Phosphorylation; Antibodies, Antiphosphopeptide-Specific; Antibodies, Phosphopeptide-Specific; Phosphopeptide-Specific Antibodies; Phosphorylation State-Specific Antibodies

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins

Proteins: 58433

Blood Proteins: 3862

Serum Globulins: 74

Immunoglobulins: 20136

Antibodies: 77322

Phospho-Specific Antibodies: 40

Immunoproteins: 30

Immunoglobulins: 20136

Antibodies: 77322

Phospho-Specific Antibodies: 40

Globulins: 305

Serum Globulins: 74

Immunoglobulins: 20136

Antibodies: 77322

Phospho-Specific Antibodies: 40

Experts

1.	Tribbick, Gordon: 1 article (01/2006)
2.	Khanna, Kum Kum: 1 article (01/2006)
3.	Gatei, Magtouf: 1 article (01/2006)

Related Diseases

1.	DNA Damage 01/01/2006 - "Phospho-specific antibodies as a tool to study in vivo regulation of BRCA1 after DNA damage." 01/20/2009 - "Furthermore, we demonstrate by mass spectrometry and phospho-specific antibodies that H2A.X-F is phosphorylated in the absence of exogenous DNA damage, in both actively dividing, unperturbed embryos and cell-free egg extract in the absence and presence of DNA damage and S-phase checkpoint conditions. " 04/01/2001 - "JNK phosphorylated p53 at T81 in response to DNA damage and stress-inducing agents, as determined by phospho-specific antibodies to T81. " 06/15/2007 - "We identified proteins cross-reacting to phospho-specific antibodies in response to DNA damage by mass spectrometry. " 12/01/2002 - "Through a combination of mutagenesis and phospho-specific antibodies, we have shown that serine at position 345 (S345) is phosphorylated in vivo in response to DNA damage, and that S345 phosphorylation is required for an intact checkpoint response. " Order ALL the reference details at left...
2.	Lymphoma (Lymphomas) 10/15/2005 - "In the present study, we found that IFN-alpha induced a sustained activation of c-Jun N-terminal kinase 1 (JNK1), but not extracellular kinases (ERKs), in Daudi B lymphoma cells, as assessed by Western blotting using phospho-specific antibodies. " Order ALL the reference details at left...
3.	Neoplasms (Cancer) 05/08/1999 - "Detection of ErbB2 oversignalling in a majority of breast cancers with phosphorylation-state-specific antibodies." 10/08/1998 - "These results refine the multi-step model for the role of Neu in mammary neoplasia and establish phosphorylation-state specific antibodies as a powerful tool for investigating tumor progression." 11/01/2003 - "We have used reverse-phase protein array technology coupled with laser capture microdissection and phospho-specific antibodies to examine the activation status of several key molecular "gates" involved in cell survival and proliferation signaling in human ovarian tumor tissue. " 08/01/2004 - "We previously showed, by immunohistochemistry with phospho-specific antibodies, increased phosphorylation (activation) of Akt (Ser(473)) [phosphorylated Akt (pAkt)] in high-Gleason grade prostate cancer (Malik SN, et al., Clin Cancer Res 2002;8:1168-71). " 08/01/2005 - "DESIGN: We evaluated 43 formalin-fixed, paraffin-embedded MCL tumors using immunohistochemistry and phospho-specific antibodies against STAT3 and JAK. " Order ALL the reference details at left...
4.	Infection 10/01/2003 - "An array of mammalian phospho-specific antibodies was used to screen for a host response upon mycobacterial infection, reflected as changes in host protein phosphorylation. " 11/01/2006 - "As assessed by Western blotting using phospho-specific antibodies, infection with rhesus rotavirus (RRV) or exposure to UV-psoralen-inactivated RRV (I-RRV) resulted in the activation of JNK in HT-29, Caco-2, and MA104 cells. " 12/01/2003 - "Using C-terminal point mutations and a novel phosphospecific antibody, Ser396 was characterized as the minimal phosphoacceptor site required in vivo for IRF-3 activation following Sendai virus (SeV) infection, expression of viral nucleocapsid, or double-stranded RNA (dsRNA) treatment. " 03/14/2003 - "Using SDS-PAGE and immunoblotting with a novel phosphospecific antibody, we show for the first time that, in vivo, IRF-3 is phosphorylated on Ser(396) following Sendai virus infection, expression of viral nucleocapsid, and double-stranded RNA treatment. " Order ALL the reference details at left...
5.	Ischemia 07/01/2000 - "These signaling pathways were studied by laser-scanning confocal microcopy and Western blot analysis using phospho-specific antibodies on rat brains that were subjected to 15 minutes transient forebrain ischemia followed by varied periods of reperfusion. " 05/01/1999 - "Western blot analysis with a phosphospecific antibody for characterization of MAPK (ERKs) activation revealed significantly increased phosphorylation of ERK1 and ERK2 in the particulate fraction, of ERK2 in the cytosolic fraction, during ischemia and of both enzymes in the particulate and cytosolic fractions after 10 min of reperfusion. " 07/01/2000 - "Translocation and phosphorylation of alpha BC was determined in cytosolic and cytoskeletal fractions by 1D SDS-PAGE and IEF, or using Ser 45 and Ser 59 phospho-specific antibodies in: (1) control rabbit cardiomyocytes; (2) cells preconditioned by 10 min in vitro ischemia; or after pre-treatment with specific inhibitors of (3) Ser/Thr protein phosphatase 1/2A (calyculin A); (4) p38 MAPK (SB203580); or (5) ERK 1/2 (PD98059); all prior to 180 min ischemia. " Order ALL the reference details at left...

Related Drugs and Biologics

1.	Phosphotransferases (Kinase)
2.	Mitogen-Activated Protein Kinase 8
3.	Focal Adhesion Protein-Tyrosine Kinases
4.	Double-Stranded RNA (RNA, Double Stranded)
5.	Proteins (Proteins, Gene)
6.	Protein Kinases (Protein Kinase)
7.	Insulin (Novolin)
8.	Protein Phosphatase 1
9.	Paxillin
10.	beta Catenin

Related Therapies and Procedures

1.	Lasers (Laser)
2.	Aftercare (After-Treatment)

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