Methenyltetrahydrofolate Cyclohydrolase

An aminohydrolase that catalyzes the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate. In most higher eucaryotic organisms this enzyme also includes METHYLENETETRAHYDROFOLATE DEHYDROGENASE (NADP) and FORMATE-TETRAHYDROFOLATE LIGASE activities.

Also Known As:

5,10-MTHF Cyclohydrolase; 5,10-Methenyltetrahydrofolate 5-Hydrolase (Decyclizing); 5,10-Methenyltetrahydrofolate Cyclohydrolase; 5,10 MTHF Cyclohydrolase; 5,10 Methenyltetrahydrofolate Cyclohydrolase; Cyclohydrolase, 5,10-MTHF; Cyclohydrolase, 5,10-Methenyltetrahydrofolate; Cyclohydrolase, Methenyltetrahydrofolate

Networked: 12 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Hydrolases: 2166
    - Aminohydrolases: 1
      - Methenyltetrahydrofolate Cyclohydrolase: 12
        Arabidopsis MTHFD1 protein
        mouse Mthfd1 protein

Experts

1.	Lianeri, Margarita: 2 articles (01/2010 - 06/2007)
2.	Brody, Lawrence C: 2 articles (04/2009 - 11/2002)
3.	Kirke, Peadar N: 2 articles (04/2009 - 11/2002)
4.	Mills, James L: 2 articles (04/2009 - 11/2002)
5.	Molloy, Anne M: 2 articles (04/2009 - 11/2002)
6.	Parle-McDermott, Anne: 2 articles (04/2009 - 11/2002)
7.	Scott, John M: 2 articles (04/2009 - 11/2002)
8.	Hu, Hao: 1 article (05/2022)
9.	Liu, Xianhui: 1 article (05/2022)
10.	Wang, Qi: 1 article (05/2022)

Related Diseases

1.	Neural Tube Defects (Exencephaly) 02/01/1998 - "Molecular genetic analysis of the gene encoding the trifunctional enzyme MTHFD (methylenetetrahydrofolate-dehydrogenase, methenyltetrahydrofolate-cyclohydrolase, formyltetrahydrofolate synthetase) in patients with neural tube defects." 11/01/2002 - "A polymorphism, R653Q, in the trifunctional enzyme methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase/formyltetrahydrofolate synthetase is a maternal genetic risk factor for neural tube defects: report of the Birth Defects Research Group." 04/01/2009 - "Genetic variants in MTHFD1 (5,10-methylenetetrahydrofolate dehydrogenase/5,10-methenyltetrahydrofolate cyclohydrolase/ 10-formyltetrahydrofolate synthetase), an important folate metabolic enzyme, are associated with a number of common diseases, including neural tube defects (NTDs). "
2.	Neoplasms (Cancer) 05/17/2022 - "The bifunctional methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase (MTHFD2) has been reported to play an oncogenic role in various types of cancers. " 04/05/1988 - "The bifunctional NAD-dependent methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase from ascites tumor cells has very different kinetic properties from the larger NADP-dependent methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase-formyltetrahydrofolate synthetase present in all mammalian cells. "
3.	Atypical Hemolytic Uremic Syndrome 07/01/2012 - "Deficiency in the trifunctional enzyme containing methylenetetrahydrofolate dehydrogenase, methenyltetrahydrofolate cyclohydrolase and formyltetrahydrofolate synthetase activities, has been identified in a single patient with megaloblastic anemia, atypical hemolytic uremic syndrome and severe combined immune deficiency. "
4.	Severe Combined Immunodeficiency (Bare Lymphocyte Syndrome) 07/01/2012 - "Deficiency in the trifunctional enzyme containing methylenetetrahydrofolate dehydrogenase, methenyltetrahydrofolate cyclohydrolase and formyltetrahydrofolate synthetase activities, has been identified in a single patient with megaloblastic anemia, atypical hemolytic uremic syndrome and severe combined immune deficiency. "
5.	Whooping Cough (Pertussis) 01/01/2021 - "Comparative structural analysis of bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase from Bordetella pertussis and Bordetella parapertussis: a drug target against pertussis."

Related Drugs and Biologics

1.	Methylenetetrahydrofolate Dehydrogenase (NADP) (Dehydrogenase, Methylenetetrahydrofolate)
2.	Formate-Tetrahydrofolate Ligase
3.	Enzymes
4.	5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase (Methyltetrahydrofolate Homocysteine Methyltransferase)
5.	Oxidoreductases (Dehydrogenase)
6.	Ligases (Synthetase)
7.	Folic Acid (Vitamin M)
8.	5,10-methylenetetrahydrofolic acid
9.	10-formyltetrahydropteroylglutamic acid
10.	Methylenetetrahydrofolate Reductase (NADPH2) (Methylenetetrahydrofolate Reductase)