3-alpha-Hydroxysteroid Dehydrogenase (B-Specific)

A 3-hydroxysteroid dehydrogenase which catalyzes the reversible reduction of the active androgen, DIHYDROTESTOSTERONE to 5 ALPHA-ANDROSTANE-3 ALPHA,17 BETA-DIOL. It also has activity towards other 3-alpha-hydroxysteroids and on 9-, 11- and 15- hydroxyprostaglandins. The enzyme is B-specific in reference to the orientation of reduced NAD or NADPH.

Also Known As:

3 alpha-Hydroxysteroid Dehydrogenase; 3 alpha-Hydroxysteroid Dehydrogenase (B-Specific); 3 alpha-Hydroxysteroid Oxidoreductase; 3alpha-Hydroxysteroid Dehydrogenase (B-specific); 5 alpha-3 alpha-Hydroxysteroid Dehydrogenase; 5 alpha-Dihydroprogesterone 3 alpha-Hydroxysteroid Oxidoreductase; 5-DP-3 alpha-HSO; NADPH-5 alpha-Dihydroprogesterone 3 alpha-Hydroxysteroid Oxidoreductase; 3 alpha Hydroxysteroid Dehydrogenase; 3 alpha Hydroxysteroid Oxidoreductase; 5 alpha Dihydroprogesterone 3 alpha Hydroxysteroid Oxidoreductase; Dehydrogenase, 3 alpha-Hydroxysteroid; NADPH 5 alpha Dihydroprogesterone 3 alpha Hydroxysteroid Oxidoreductase; Oxidoreductase, 3 alpha-Hydroxysteroid

Networked: 16 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Oxidoreductases: 13671
    - Alcohol Oxidoreductases: 56
      - Hydroxysteroid Dehydrogenases: 313
        3-Hydroxysteroid Dehydrogenases: 172
        3-alpha-Hydroxysteroid Dehydrogenase (B-Specific): 16
      - NAD (+) and NADP (+) Dependent Alcohol Oxidoreductases
        3-alpha-Hydroxysteroid Dehydrogenase (B-Specific): 16

Experts

1.	Beyenburg, Stefan: 1 article (04/2003)
2.	Bidlingmaier, Frank: 1 article (04/2003)
3.	Casarosa, Elena: 1 article (04/2003)
4.	Clusmann, Hans: 1 article (04/2003)
5.	Elger, Christian E: 1 article (04/2003)
6.	Ludwig, Michael: 1 article (04/2003)
7.	Luisi, Stefano: 1 article (04/2003)
8.	Steckelbroeck, Stephan: 1 article (04/2003)
9.	Stoffel-Wagner, Birgit: 1 article (04/2003)
10.	Watzka, Matthias: 1 article (04/2003)

Related Diseases

1.	Open-Angle Glaucoma (Glaucoma, Open Angle) 01/01/1996 - "The purpose of the present study was to determine whether peripheral blood lymphocytes (PBL) from primary open angle glaucoma (POAG) patients have reduced 3 alpha-hydroxysteroid dehydrogenase (3 alpha-HSD) activity as was previously found in POAG-derived cultured trabecular meshwork cells. " 01/01/1996 - "Decreased 3 alpha-hydroxysteroid dehydrogenase activity in peripheral blood lymphocytes from patients with primary open angle glaucoma."
2.	Neoplasms (Cancer) 05/01/1999 - "5 alpha-reductase activity was similar in all tumors, 3 alpha-hydroxysteroid dehydrogenase activity was the highest while that of 17 beta-hydroxysteroid dehydrogenase was the lowest. " 05/01/1978 - "The NADH-linked 3 alpha-hydroxysteroid dehydrogenase activity was detected only in the cytosol fraction of the normal mammary gland, but in the tumor studied, the activity of this enzyme was detected in all the subcellular fractions examined." 05/01/1978 - "The activities of 20 alpha-hydroxysteroid dehydrogenase and NADPH-linked 3 alpha-hydroxysteroid dehydrogenase were found mainly in the cytosol fractions of the tumor and the normal tissue. " 09/01/1983 - "In dimethylbenz(a)anthracene-induced tumor tissue, high 5 alpha-reductase and 20 alpha-hydroxysteroid dehydrogenase activities and somewhat lower 3 alpha-hydroxysteroid dehydrogenase and 6 alpha-hydroxylase activities were found. "
3.	Feminization 12/01/1979 - "With the exception of cytoplasmic 3 alpha-hydroxysteroid dehydrogenase, 5 microgram oestradiol/d for 8 days and less was sufficient to cause complete feminization. " 01/01/1979 - "The influence of oestradiol on these activities in gonadectomized rats was determined by the mode of sex hormone-dependent regulation of the individual activity: the most prominent effects were seen in the oestrogen-dependent activities (17 beta-hydroxysteroid dehydrogenase, 5 beta-reductase); no effect was seen in the completely androgen-dependent 3 alpha-hydroxysteroid dehydrogenase because gonadectomy alone was sufficient to cause complete feminization of the activity. "
4.	Carcinoma (Carcinomatosis) 03/01/1985 - "The following observations were made when comparing individual enzymatic activities between the 3 tissue groups: 1) mean 5 alpha-reductase activity was lower in carcinoma than in both normal prostate and BPH (p less than 0.05), 2) mean 3 alpha-hydroxysteroid oxidoreductase and 3 beta-hydroxysteroid oxidoreductase activities were greater in carcinoma than in BPH (p less than 0.05) and 3) mean acid phosphatase activity was higher in BPH than in both normal prostate and carcinoma (p less than 0.01). " 12/01/1995 - "Using high performance liquid chromatography and immobilized 3 alpha-hydroxysteroid dehydrogenase in column form, significant increases in the proportion of chenodeoxycholic acid and significant decreases in the proportion of deoxycholic acid and lithocholic acid were found in the bile of patients with colorectal adenoma or carcinoma compared with the control subjects. "
5.	Small Cell Lung Carcinoma (Small Cell Lung Cancer) 04/15/1989 - "The presence of 5 alpha-reductase activity, 17 beta-hydroxysteroid-dehydrogenase and 3 alpha-hydroxysteroid-dehydrogenase activities could be demonstrated, suggesting testosterone metabolism of small-cell lung cancer cell lines."

Related Drugs and Biologics

1.	Cholestenone 5 alpha-Reductase (5 alpha-Reductase)
2.	Hydroxysteroid Dehydrogenases
3.	20-alpha-Hydroxysteroid Dehydrogenase
4.	Testosterone (Sustanon)
5.	Oxidoreductases (Dehydrogenase)
6.	Lithocholic Acid
7.	Estradiol (Delestrogen)
8.	Enzymes
9.	Deoxycholic Acid (Sodium Deoxycholate)
10.	Chenodeoxycholic Acid (Chenix)

Related Therapies and Procedures

1.	Castration