Flavonolignans

01/01/2016 - "This summarization aims to provide valuable insights into further and rational development of flavonolignans for prostate cancer management by interpreting the data reported in the literature."
01/01/2016 - "Certain flavonolignans can synergize with well-established chemotherapeutic agents for prostate cancer. "
01/01/2016 - "Recently, the medicinal merit of flavonolignans has been extended to the prostate cancer management. "
01/01/2016 - "The Potential of Flavonolignans in Prostate Cancer Management."
05/15/2005 - "Milk thistle and prostate cancer: differential effects of pure flavonolignans from Silybum marianum on antiproliferative end points in human prostate carcinoma cells."

01/01/2020 - "The availability of novel formulations with improved bioavailability, and data from phase I clinical trials in cancer patients provide an encouraging basis for more extensive trials aimed at evaluating the benefits of Silybum flavonolignans in cancer management. "
05/01/2023 - "Silybum marianum seeds contain a family of flavonolignans which can regulate cancer cell proliferation and apoptosis. "
01/01/2021 - "These results would pave the way for further investigation on the derivatives of flavonolignans for the treatment of cancer."
01/01/2020 - "The review provides an outline of the various ways in which flavonolignans advance the combat against cancer. "
01/01/2020 - "Flavonolignans: One Step Further in the Broad-Spectrum Approach of Cancer."

09/01/2008 - "The aim of this study was to determine the pharmacokinetics of the major silymarin flavonolignans in liver disease patients. "
09/01/2008 - "Silymarin, used by 30 to 40% of liver disease patients, is composed of six major flavonolignans, each of which may contribute to silymarin's hepatoprotective properties. "
01/01/1998 - "Silymarin, a mixture of flavonolignans from medicinal plant Silybum marianum, is used in supportive treatment of liver diseases of different etiology due to its hepatoprotective activity, which is considered to involve antioxidative and the membrane stabilizing effects. "
12/01/2011 - "The single- and multiple-dose pharmacokinetics of silymarin flavonolignans were examined in patients with nonalcoholic fatty liver disease (NAFLD) or hepatitis C virus (HCV) to determine whether the disposition of silymarin and therefore its potential efficacy vary among liver disease populations. "
07/01/2019 - "Silymarin, an extract from Silybum marianum (milk thistle) containing a standardized mixture of flavonolignans that ameliorates some types of liver disease and, more recently, kidney damage, could be used for the ROS-scavenging effect of these antioxidants. "

11/05/2005 - "Silymarin, a standardized mixture of flavonolignans, or its major constituents could be effective for prevention and treatment of hepatic damage or skin cancer. "

03/01/2016 - "The primary purpose of this study was to examine the phototoxicity of silymarin and its flavonolignans, silybin, isosilybin, silychristin, silydianin and 2,3-dehydrosilybin by validated 3T3 NRU assay. "
03/01/2016 - "The results showed that silymarin and the flavonolignans silybin, isosilybin, silychristin and silydianin had no phototoxicity towards any of the cells used. "