Electron-Transferring Flavoproteins (Electron Transfer Flavoprotein)

Flavoproteins that serve as specific electron acceptors for a variety of DEHYDROGENASES. They participate in the transfer of electrons to a variety of redox acceptors that occur in the respiratory chain.

Also Known As:

Electron Transfer Flavoprotein; ET Flavoprotein; Electron-Transferring Flavoprotein; Electron Transferring Flavoprotein; Electron Transferring Flavoproteins; Flavoprotein, ET; Flavoprotein, Electron Transfer; Flavoprotein, Electron-Transferring; Flavoproteins, Electron-Transferring; Transfer Flavoprotein, Electron

Networked: 82 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Yamaguchi, Seiji: 5 articles (08/2019 - 05/2008)
2.	Wanders, Ronald J A: 3 articles (01/2021 - 12/2005)
3.	Fukuda, Seiji: 3 articles (08/2019 - 05/2008)
4.	Hasegawa, Yuki: 3 articles (08/2019 - 05/2008)
5.	Kobayashi, Hironori: 3 articles (08/2019 - 05/2008)
6.	Ali, Amanat: 2 articles (01/2021 - 01/2021)
7.	Almesmari, Fatmah Saeed Ali: 2 articles (01/2021 - 01/2021)
8.	Dercksen, Marli: 2 articles (01/2021 - 01/2018)
9.	Dhahouri, Nahid Al: 2 articles (01/2021 - 01/2021)
10.	Schoonen, Maryke: 2 articles (01/2021 - 01/2018)

Related Diseases

1.	Multiple Acyl Coenzyme A Dehydrogenase Deficiency 11/01/2010 - "Mutational hotspots in electron transfer flavoprotein underlie defective folding and function in multiple acyl-CoA dehydrogenase deficiency." 05/01/2002 - "A case of neonatal-onset glutaric acidemia type II with electron-transfer flavoprotein (ETF) deficiency is presented. " 03/01/1994 - "Mutations and polymorphisms of the gene encoding the beta-subunit of the electron transfer flavoprotein in three patients with glutaric acidemia type II." 01/01/1991 - "Newly identified forms of electron transfer flavoprotein (ETF) deficiency in two patients with glutaric aciduria type II (GA II) were described. " 01/01/1990 - "A new variant of glutaric aciduria type II: deficiency of beta-subunit of electron transfer flavoprotein."
2.	Metabolic Diseases (Metabolic Disease) 12/01/2022 - "Multiple acyl-CoA dehydrogenase deficiency (MADD) is an inherited metabolic disease caused by a defect in electron transfer flavoprotein alpha (ETFA), ETF beta (ETFB), or ETF dehydrogenase (ETFDH), and riboflavin metabolism disorders have recently been reported to present as mimicking MADD. " 06/01/2021 - "In infancy multiple acyl-CoA dehydrogenase deficiency (MADD) is commonly a severe inherited metabolic disease caused by genetic defects in electron transfer flavoprotein (ETF) or ETF ubiquinone oxidoreductase. " 10/17/1997 - "Defects in electron transfer flavoprotein (ETF) or its electron acceptor, electron transfer flavoprotein-ubiquinone oxidoreductase (ETF-QO), cause the human inherited metabolic disease glutaric acidemia type II. In this disease, electron transfer from nine primary flavoprotein dehydrogenases to the main respiratory chain is impaired. "
3.	Muscle Weakness 02/05/2019 - "All patients presented with muscle weakness or exercise intolerance associated with variants in the electron transfer flavoprotein dehydrogenase gene. " 01/01/2015 - "We report a novel mutation in the electron transfer flavoprotein dehydrogenase (EFTDH) gene in an adolescent Chinese patient with late-onset riboflavin-responsive multiple acyl-CoA dehydrogenase deficiency (MADD) characterized by muscle weakness as early symptom. "
4.	Neoplasms (Cancer) 01/01/2018 - "The most significant associated gene in the discovery cohort was ETFB (electron transfer flavoprotein beta subunit) involved in mitochondrial β-oxidation and ATP production (P = 4.16 × 10-4) and this association was replicated in an independent set of anthracycline-treated cancer patients (P = 2.81 × 10-3). " 01/01/2018 - "Instead the responses after early life stage + 1 year irradiation are consistently associated with tumorigenesis, cancer progression, or are otherwise damaging: upregulation of alpha-globin 1 (YSL + 1 year and first feeders + 1 year) and downregulation of histone H1, type II keratin, malate dehydrogenase 2-2, Na/K ATPase alpha subunit isoform 1b, nucleoside diphosphate kinase (48 h egg + 1 year), electron transfer flavoprotein subunit alpha (eyed egg + 1 year), 60 S ribosomal protein L30 (YSL + 1 year) and haemoglobin subunit beta-4 (first feeder + 1 year). "
5.	Muscular Diseases (Myopathy) 06/01/2013 - "Our previous data showed that in a group of Chinese patients, a mild type of MADD characterized by myopathy with clinically no other systemic involvement was caused by mutations in electron transfer flavoprotein dehydrogenase (ETFDH) gene, which encodes electron transfer flavoprotein: ubiquinone oxidoreductase (ETF:QO). " 11/01/2020 - "A family with riboflavin-reactive lipid deposition myopathy caused by a novel compound heterozygous mutation in the electron transfer flavoprotein dehydrogenase gene."

Related Drugs and Biologics

1.	Acyl-CoA Dehydrogenases
2.	Methionine (L-Methionine)
3.	Oxidoreductases (Dehydrogenase)
4.	Ubiquinone
5.	Fatty Acids (Saturated Fatty Acids)
6.	electron-transferring-flavoprotein dehydrogenase (ETF dehydrogenase)
7.	Riboflavin (Vitamin B2)
8.	Proteins (Proteins, Gene)
9.	Amino Acids
10.	acylcarnitine