beta-Transducin Repeat-Containing Proteins

A family of F-box domain proteins that contain sequences that are homologous to the beta subunit of transducin (BETA-TRANSDUCIN). They play an important role in the protein degradation pathway by becoming components of SKP CULLIN F-BOX PROTEIN LIGASES, which selectively act on a subset of proteins including beta-catenin and IkappaBbeta.

Also Known As:

Networked: 54 relevant articles (0 outcomes, 3 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Fuchs, Serge Y: 7 articles (04/2009 - 03/2004)
2.	Hsu, Han-Shui: 3 articles (02/2010 - 09/2009)
3.	Wang, Yi-Ching: 3 articles (02/2010 - 09/2009)
4.	Chen, Ching-Shih: 3 articles (07/2009 - 09/2007)
5.	Wei, Shuo: 3 articles (07/2009 - 09/2007)
6.	Li, Ying: 3 articles (03/2008 - 03/2005)
7.	Benarous, Richard: 3 articles (02/2007 - 01/2006)
8.	Pietsch, Torsten: 3 articles (06/2005 - 08/2002)
9.	Ben-Neriah, Yinon: 2 articles (01/2019 - 02/2010)
10.	Tzao, Ching: 2 articles (01/2010 - 09/2009)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2010 - "HCC tumor tissues with homozygous for 9N ins/ins has the highest level of betaTrCP, which are 3.99 and 7.04-fold higher than heterozygous 9N ins/del and homozygous 9N del/del, respectively. " 01/01/2009 - "These results suggest that F-PBF(beta-TrCP) could be used for cancer treatment by targeted degradation of PTTG1." 03/20/2008 - "Furthermore, we find that beta-TRCP overexpression, which is common in human epithelial cancers, causes oncogenic transformation of human mammary epithelial cells and that this pathogenic function requires REST degradation. " 06/01/2007 - "Our results indicate that the turnover of Mcl-1 by beta-TrCP is an essential mechanism for GSK-3beta-induced apoptosis and contributes to GSK-3beta-mediated tumor suppression and chemosensitization." 06/01/2006 - "Binding of betaTrCP to Gli3 N- and C-terminal domains lacking DSGX2-4S-related motifs was also observed, which could reflect indirect interaction via other components of Hedgehog signaling, such as the tumor suppressor Sufu. "
2.	Adenomatous Polyposis Coli (Familial Adenomatous Polyposis) 10/30/1999 - "In the absence of an activating signal, phosphorylation of beta-catenin by glycogen synthase kinase 3 (GSK3) acting in conjunction with adenomatous polyposis coli and axin/conductin causes beta-catenin to interact with the beta-transducin repeat-containing protein which results in its ubiquitination and degradation. " 05/18/2007 - "This assay revealed that WTX, a protein encoded by a gene mutated in Wilms tumors, forms a complex with beta-catenin, AXIN1, beta-TrCP2 (beta-transducin repeat-containing protein 2), and APC (adenomatous polyposis coli). " 08/10/2002 - "We investigated 37 malignant melanomas (15 primary tumors and 22 metastases) for alterations of 4 genes encoding members of this pathway, i.e., CTNNB1 (beta-catenin gene, 3p22.1), APC (adenomatous polyposis coli gene, 5q22.2), BTRC (beta-transducin repeat-containing protein gene, 10q24.3) and ICAT (inhibitor of beta-catenin and Tcf-4, 1p36.2). " 12/05/2008 - "Here we show that the SCF(beta-TrCP) binding site created by phosphorylation of beta-catenin is highly vulnerable to protein phosphatase 2A (PP2A) and must be protected by the adenomatous polyposis coli (APC) tumor suppressor protein. " 02/23/2004 - "In several tumour types, TCF/beta-catenin activation is caused by mutations in either adenomatous polyposis coli (APC), beta-catenin exon 3, AXIN1, AXIN2 or beta-transducin repeat-containing protein (beta-TrCP). "
3.	Lung Neoplasms (Lung Cancer) 01/01/2005 - "Here, we provide evidence to support that beta-TRCP negatively regulates cell growth and motility of lung cancer cells. " 01/01/2005 - "Regulation of lung cancer cell growth and invasiveness by beta-TRCP." 01/15/2010 - "Importantly, SLIT2, betaTrCP, and beta-catenin expression levels predicted postoperative recurrence of lung cancer in patients. " 07/24/2008 - "In addition, a high level of p53 downregulates the beta-catenin expression, but this effect is attenuated by non-functional AXIN2 or betaTrCP in lung cancer." 07/24/2008 - "Ectopic expression and knockdown of p53, AXIN2 and betaTrCP genes in A549 (p53 wild-type) and H1299 (p53 null) lung cancer cell lines showed cooperation between p53 and AXIN2/betaTrCP in the reduction of beta-catenin expression. "
4.	Squamous Cell Carcinoma (Epidermoid Carcinoma) 09/01/2009 - "Our study investigates the significance of the expression of Wnt pathway proteins including beta-catenin, Axin, beta-transducin-repeat-containing protein (beta-TrCP), and adenomatous polyposis coli (APC) in squamous cell carcinoma of the esophagus (ESCC). "
5.	Carcinogenesis 02/05/2010 - "beta-TrCP is an E3 ligase that targets various substrates essential for many aspects of tumorigenesis. " 07/24/2008 - "Epigenetic silencing of AXIN2/betaTrCP and deregulation of p53-mediated control lead to wild-type beta-catenin nuclear accumulation in lung tumorigenesis." 06/01/2005 - "The involvement of GSK-3beta and beta-Trcp in the regulation of Snail is particular interesting, because these two molecules are also known to involve in the regulation of Wnt and hedgehog pathways that are known to control cell fate and morphogenesis during development and tumorigenesis. " 07/24/2008 - "Our clinical and cell model findings provide new evidence that epigenetic silencing of AXIN2/betaTrCP in the degradation complex and deregulation of p53-mediated control lead to wild-type beta-catenin nuclear accumulation in non-small cell lung cancer tumorigenesis. " 01/01/2012 - "The Fbw7 and betaTRCP E3 ubiquitin ligases and their roles in tumorigenesis."

Related Drugs and Biologics

1.	beta-Transducin Repeat-Containing Proteins
2.	beta Catenin
3.	Proteins (Proteins, Gene)
4.	Glycogen Synthase Kinases
5.	Glycogen Synthase Kinase 3 beta
6.	Lysine (L-Lysine)
7.	Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)
8.	Ligases (Synthetase)
9.	Ubiquitin
10.	Proteasome Endopeptidase Complex (Proteasome)

Related Therapies and Procedures

1.	Therapeutics