A G-protein-coupled, proteinase-activated receptor that is expressed in a variety of tissues including ENDOTHELIUM; LEUKOCYTES; and the GASTROINTESTINAL TRACT. The receptor is activated by TRYPSIN, which cleaves off the N-terminal peptide from the receptor. The new N-terminal peptide is a cryptic ligand for the receptor. The uncleaved receptor can also be activated by the N-terminal peptide present on the activated THROMBIN RECEPTOR and by small synthetic peptides that contain the unmasked N-terminal sequence.
Also Known As:
Receptor, PAR-2; PAR2 Receptor; Protease-Activated Receptor 2; Receptor, Trypsin; Trypsin Receptor; Trypsin Receptors; PAR 2 Receptor; Protease Activated Receptor 2; Receptor 2, Protease-Activated; Receptor, PAR 2; Receptor, PAR2; Receptors, Trypsin; Proteinase Activated Receptor 2