|1.||Reynolds, Gavin P: 14 articles (08/2012 - 06/2002)|
|2.||Higgins, Guy A: 7 articles (02/2016 - 11/2003)|
|3.||Fletcher, Paul J: 7 articles (02/2016 - 11/2003)|
|4.||Langhans, Wolfgang: 5 articles (01/2010 - 01/2003)|
|5.||Heisler, Lora K: 4 articles (06/2014 - 11/2007)|
|6.||Nakai, Kunihiro: 4 articles (01/2013 - 02/2008)|
|7.||Nakae, Aya: 4 articles (01/2013 - 02/2008)|
|8.||Nonogaki, Katsunori: 4 articles (01/2012 - 07/2002)|
|9.||Tecott, Laurence H: 4 articles (01/2010 - 07/2002)|
|10.||Thomsen, William J: 4 articles (05/2008 - 03/2005)|
10/01/2000 - "The 5-HT2C receptor may prove to be a useful target in the development of clinically effective drugs for the treatment of obesity."
01/01/2012 - "5-HT2C receptor antagonists are thought to contribute toward increased appetite and obesity. "
01/01/2012 - "This suggests that a dynamic regulation exists of the appetite-suppressing effects of the 5-HT(2C) receptor in both the hypothalamus and the hippocampus in the ob/ob mice model of obesity. "
01/01/2012 - "Dynamic 5-HT2C receptor editing in a mouse model of obesity."
01/01/2012 - "Agonists of the 5-HT(2C) receptor have attracted much attention as therapeutic agents for the treatment of obesity. "
|2.||Weight Loss (Weight Reduction)
09/01/2015 - "Weight Loss After RYGB Is Independent of and Complementary to Serotonin 2C Receptor Signaling in Male Mice."
06/01/2002 - "Association between a polymorphism of the 5-HT2C receptor and weight loss in teenage girls."
04/01/2004 - "A 5-HT2C receptor promoter polymorphism (HTR2C - 759C/T) is associated with obesity in women, and with resistance to weight loss in heterozygotes."
07/01/2000 - "In light of the sustained drug effect on body weight, the data suggest that weight loss by 5-HT(2C) receptor stimulation may be only partly dependent on changes in food consumption and that 5-HT(2C) receptor agonists may have effects on thermogenesis. "
01/01/2003 - "Indirect evidence stems from recent observations that the clinically effective anorectic agent d-fenfluramine exerts its hypophagic and weight-loss effects via 5-HT(2C) receptor activation. "
|3.||Body Weight (Weight, Body)
07/01/2013 - "Small molecule activation of the 5-HT2C receptor has been shown to affect food intake and regulate body weight gain in rodent models and more recently in human clinical trials. "
01/01/2003 - "Furthermore, recent studies have also shown that 5-HT(2C) receptor agonists not only reduce feeding when acutely administered to rats or mice, they can also reduce body weight without inducing tolerance when administered chronically to obese animals. "
02/01/2010 - "Agonists of the 5-HT(2C) receptor have been shown to suppress appetite and reduce body weight in animal models as well as in humans. "
07/01/2003 - "To test this, we examined the effect of two intensities of repeated stress on food intake and body weight in 5-HT(2C) receptor KO and wild-type (WT) mice. "
05/01/2003 - "To assess whether chronic administration of the preferential 5-HT(2C) receptor agonist, mCPP, reduces rat body weight gain and to determine if this effect is wholly or partially attributable to the effect of the drug on daily food intake. "
|4.||Schizophrenia (Dementia Praecox)
02/01/2011 - "The objective of this study was to determine the association of 5-HT2C (serotonin 2C receptor) and MDR1 (multidrug resistant protein) genetic polymorphisms and antipsychotic-induced metabolic abnormalities among female patients with DSM IV schizophrenia spectrum disorders. "
03/01/2005 - "Pharmacogenetics of treatment in first-episode schizophrenia: D3 and 5-HT2C receptor polymorphisms separately associate with positive and negative symptom response."
12/01/2003 - "RNA editing and alternative splicing of human serotonin 2C receptor in schizophrenia."
07/01/2001 - "RNA editing of the 5-HT(2C) receptor is reduced in schizophrenia."
01/01/1997 - "Genetically determined variation in the 5-HT2C receptor may influence the clinical course and phenotypic expression of schizophrenia."
|5.||Migraine Disorders (Migraine)
06/01/2004 - "The goal of this study is to clarify the association between migraine and Serotonin 2C receptor Cys23Ser polymorphism in Japanese population. "
02/01/2003 - "An investigation of the 5-HT2C receptor gene as a migraine candidate gene."
01/01/1997 - "In humans, a bolus dose of mCPP can cause alcohol craving (in abstinent alcoholics) and migraine (in susceptible persons), suggesting that there is a 5-HT2C receptor hyperresponsiveness in these conditions also. "
05/01/1996 - "Correlation of the receptor affinities with the potencies used in migraine prophylaxis showed significant correlations, which were better for the 5-HT2B (P = 0.001) than for the 5-HT2C receptor (P = 0.005). "
04/01/1996 - "The coding region of the 5-HT2A and 5-HT2C receptor genes was also analyzed in migraine patients and unaffected controls using polmerase chain reaction and direct sequencing. "
|1.||S 20098 (agomelatine)
|2.||Serotonin (5 Hydroxytryptamine)
|3.||8- chloro- 2,3,4,5- tetrahydro- 1- methyl- 1H- 3- benzazepine
|5.||MT2 Melatonin Receptor
|3.||Drug Therapy (Chemotherapy)