|1.||Maroteaux, Luc: 9 articles (11/2015 - 07/2003)|
|2.||Monassier, Laurent: 3 articles (11/2015 - 07/2003)|
|3.||Launay, Jean-Marie: 3 articles (01/2007 - 07/2003)|
|4.||Nebigil, Canan G: 3 articles (08/2004 - 07/2003)|
|5.||Jaffré, Fabrice: 3 articles (08/2004 - 07/2003)|
|6.||Doly, Stéphane: 2 articles (11/2015 - 06/2012)|
|7.||Lübbert, Hermann: 2 articles (03/2015 - 01/2015)|
|8.||Segelcke, Daniel: 2 articles (03/2015 - 01/2015)|
|9.||Launay, J-M: 2 articles (08/2008 - 10/2002)|
|10.||Callebert, J: 2 articles (08/2008 - 10/2002)|
|1.||Migraine Disorders (Migraine)
01/01/2015 - "This model has predictive value for antimigraine drugs but cannot explain the delayed onset of efficacy of 5-HT2B receptor antagonists when clinically used for migraine prophylaxis. "
01/01/2015 - "It seems striking, that chronic endogenous activation of 5-HT2B receptors is crucial for the sensitization since 5-HT2B receptor antagonists have strong, albeit delayed migraine prophylactic efficacy. "
01/01/1998 - "A role for 5-HT2B receptors has also been suggested the initiation of migraine, supporting use of selective 5-HT2B receptor antagonists in migraine. "
03/15/2015 - "Serotonin 5-HT2B receptor antagonists have been proposed as migraine prophylactic drugs, but previously available 5-HT2B receptor antagonists displayed multiple monoaminergic side effects and had to be withdrawn from the market. "
05/01/1999 - "1. Serotonin has been implicated as a mediator involved in migraine headache, an effect that may involve central 5-HT2B receptor activation. "
|2.||Heart Valve Diseases (Valvular Heart Disease)
07/01/2014 - "The 5-HT2B receptor, expressed on heart valves, acts as culprit receptor for drug-induced valvular heart disease (VHD). "
12/01/2004 - "Fibrotic valvular heart disease is not related to chemical class but to biological function: 5-HT2B receptor activation plays crucial role."
08/01/2009 - "Recent studies have suggested that both right-sided and left-sided drug-induced heart valve disease involves increased serotoninergic activity and in particular activation of the 5-HT receptors, including the 5-HT2B receptor subtype, which mediate many of the central and peripheral functions of serotonin. "
|3.||Parkinson Disease (Parkinson's Disease)
|4.||Pulmonary Hypertension (Ayerza Syndrome)
04/01/2013 - "Response to overexpression of 5-hydroxytryptamine 2B receptor gene in pulmonary hypertension: still a long way to understand its transcriptional regulation."
04/01/2013 - "Overexpression of 5-hydroxytryptamine 2B receptor gene in pulmonary hypertension: still a long way to understand its transcriptional regulation."
01/01/2007 - "A heterozygous mutation was identified in the 5-HT2B receptor gene of a patient who developed pulmonary hypertension after fenfluramines anorexigen treatment. "
01/01/2004 - "Furthermore, mice with pharmacological or genetic ablation of 5-HT2B receptor are totally resistant to hypoxia-induced pulmonary hypertension, indicating that this receptor is regulating the pathologic vascular proliferation leading to this disease. "
10/01/2002 - "Function of the serotonin 5-hydroxytryptamine 2B receptor in pulmonary hypertension."
|5.||Hypertension (High Blood Pressure)
01/01/2004 - "The 5-HT2B receptor is also implicated in systemic hypertension. "
07/01/2001 - "Also, the involvement of the 5-HT2B receptor in the vascular growth often observed in hypertension is likely. "
03/01/1999 - "We hypothesized that the 5-HT2B receptor may play a role in maintaining the high blood pressure of DOCA-salt-hypertensive rats, and herein we provide data connecting in vitro and in vivo findings. "
05/01/2007 - "With the knowledge that (+)-norfenfluramine also has affinity for 5-HT2B receptors and that arterial 5-HT2B receptor expression is up-regulated in deoxycorticosterone acetate (DOCA)-salt hypertension, we tested the hypothesis that (+)-norfenfluramine-induced vasoconstriction and pressor effects are potentiated in DOCA-salt hypertensive rats in a 5-HT2 receptor-dependent manner. "
|1.||Serotonin (5 Hydroxytryptamine)
|2.||1- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)
|4.||1- (5- (2- thenyloxy)- 1H- indol- 3- yl)propan- 2- amine
|7.||Serotonin 5-HT2 Receptor Antagonists
|8.||Interleukin-1beta (Interleukin 1 beta)
|9.||5-HT2C Serotonin Receptor
|10.||Peroxynitrous Acid (Peroxynitrite)