GTP-Binding Protein alpha Subunits

The GTPase-containing subunits of heterotrimeric GTP-binding proteins. When dissociated from the heterotrimeric complex these subunits interact with a variety of second messenger systems. Hydrolysis of GTP by the inherent GTPase activity of the subunit causes it to revert to its inactive (heterotrimeric) form. The GTP-Binding protein alpha subunits are grouped into families according to the type of action they have on second messenger systems.

Also Known As:

Networked: 54 relevant articles (0 outcomes, 3 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Birnbaumer, Lutz: 3 articles (01/2021 - 06/2007)
2.	Bastepe, Murat: 3 articles (01/2018 - 10/2003)
3.	Kilic, E: 2 articles (07/2013 - 09/2009)
4.	Vaarwater, J: 2 articles (07/2013 - 09/2009)
5.	de Klein, A: 2 articles (07/2013 - 09/2009)
6.	Edwards, Robert A: 2 articles (07/2008 - 06/2007)
7.	Weinstein, Lee S: 2 articles (03/2007 - 09/2003)
8.	Hendy, Geoffrey N: 2 articles (05/2006 - 10/2003)
9.	Jüppner, Harald: 2 articles (05/2006 - 10/2003)
10.	Blakely, Randy D: 1 article (01/2021)

Related Diseases

1.	Adenoma (Adenomas) 07/01/2018 - "Activating somatic mutations of the GNAS gene (known as gsp oncogene) which encodes the stimulatory G protein alpha-subunit (Gsα) have been found in a small number of adrenocortical secreting adenomas and rarely in PMAH. " 03/01/2008 - "Some studies have found better responses to somatostatin analogues in G-protein alpha subunit (Gsalpha) mutation (gsp oncogene)-positive adenomas. " 02/15/1993 - "Stimulation of human thyroid growth via the inhibitory guanine nucleotide binding (G) protein Gi: constitutive expression of the G-protein alpha subunit Gi alpha-1 in autonomous adenoma."
2.	Cardiomyopathies (Cardiomyopathy) 01/01/1997 - "The goal of this study was to determine whether chronic endogenous sympathetic stimulation resulting from the overexpression of cardiac stimulatory G protein alpha subunit (Gs alpha) in transgenic mice (15.3 +/- 0.1 mo old) resulted in a clinical picture of cardiomyopathy. "
3.	Malaria 12/01/2008 - "Functional studies have demonstrated an interaction between the stimulatory G protein alpha subunit (G-alpha-s) and the malaria parasite at a cellular level. "
4.	Pseudohypoparathyroidism 01/01/2011 - "PHP Ia is caused by heterozygous inactivating mutations in GNAS, which encodes the stimulatory G-protein alpha subunit (Gsa). " 12/01/2006 - "Moreover, alteration in genes encoding for second messengers may cause forms of resistance other than those due to receptor mutations, the most important one being that of an inactivating mutation in the G-protein alpha-subunit leading to TSH resistance in the setting of pseudohypoparathyroidism type 1a. " 05/01/2006 - "Most loss of function mutations of GNAS identified in different forms of pseudohypoparathyroidism disrupt not only the stimulatory G protein alpha-subunit (Gsalpha), but also its paternally expressed variant, XLalphas. " 10/01/2003 - "PHP-Ib is thus distinct from PHP-Ia, which is caused by mutations in the GNAS exons encoding the G protein alpha subunit. " 09/01/2003 - "The stimulatory G protein alpha-subunit Gs alpha is imprinted in human thyroid glands: implications for thyroid function in pseudohypoparathyroidism types 1A and 1B."
5.	Neoplasms (Cancer) 08/04/2022 - "About 40% of these tumors have somatic mutations in the stimulatory G protein alpha-subunit 1 gene. " 01/01/2020 - "G-protein alpha-subunit (GNAS)-activating mutations have recently been reported to form a rare subgroup of inflammatory liver tumors. " 01/01/2018 - "GNAS mutations leading to constitutively active stimulatory G protein alpha-subunit (Gsα) cause different tumors, fibrous dysplasia of bone, and McCune-Albright syndrome, which are typically not associated with short stature. " 11/01/1989 - "ADP ribosylation of a G-protein alpha subunit by PT decreased both the migration of tumor cells through Matrigel (Collaborative Research, Bedford, MA) and the fibronectin-, laminin-, and collagen type IV-mediated motility of a high metastatic clone. " 06/01/2008 - "Furthermore, TP-beta mediated multiple biological effects by signaling through either G-protein alpha subunit 12 or beta-arrestin 2. Treatment of mice with the TP receptor antagonist GR32191, alone or in combination with cisplatin, significantly delayed tumor onset and prolonged survival of mice transplanted with TCC-SUP bladder cancer cells compared with vehicle or cisplatin alone. "

Related Drugs and Biologics

1.	Somatostatin (Somatotropin Release-Inhibiting Factor)
2.	GTP-Binding Proteins (G-Protein)
3.	Messenger RNA (mRNA)
4.	Adenylyl Cyclases (Adenylyl Cyclase)
5.	Protein Isoforms (Isoforms)
6.	Human Growth Hormone (Saizen)
7.	Proteins (Proteins, Gene)
8.	Guanine Nucleotides
9.	Rho Guanine Nucleotide Exchange Factors
10.	Ghrelin Receptors