A serotonin receptor subtype that is localized to the CAUDATE NUCLEUS; PUTAMEN; the NUCLEUS ACCUMBENS; the HIPPOCAMPUS, and the RAPHE NUCLEI. It plays a role as a terminal autoreceptor that regulates the rate of SEROTONIN release from nerve endings. This serotonin receptor subtype is closely related to and has similar drug binding properties as the 5-HT1B RECEPTOR, but is expressed at low levels. It is particularly sensitive to the agonist SUMATRIPTAN and may be involved in mediating the drug's antimigrane effect.
Also Known As:
Receptor, Serotonin, 5-HT1D; 5-HT(1D) Receptor; 5-HT(1Dalpha) Receptor; 5-HT1D Receptor; 5-HT1Dalpha Receptor; 5-Hydroxytryptamine1D Receptor; Receptor, Serotonin 1D; Receptor, Serotonin 1Dalpha; Serotonin 1D Alpha Receptor; Serotonin 1D Receptors; Serotonin 1Dalpha Receptor; Serotonin 1Dalpha Receptors; 5 HT1D Receptor; 5 Hydroxytryptamine1D Receptor; Receptor, 5-HT1D; Receptor, 5-Hydroxytryptamine1D; Receptors, Serotonin 1D; Serotonin 1D Receptor