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5-HT1D Serotonin Receptor

A serotonin receptor subtype that is localized to the CAUDATE NUCLEUS; PUTAMEN; the NUCLEUS ACCUMBENS; the HIPPOCAMPUS, and the RAPHE NUCLEI. It plays a role as a terminal autoreceptor that regulates the rate of SEROTONIN release from nerve endings. This serotonin receptor subtype is closely related to and has similar drug binding properties as the 5-HT1B RECEPTOR, but is expressed at low levels. It is particularly sensitive to the agonist SUMATRIPTAN and may be involved in mediating the drug's antimigrane effect.
Also Known As:
Receptor, Serotonin, 5-HT1D; 5-HT(1D) Receptor; 5-HT(1Dalpha) Receptor; 5-HT1D Receptor; 5-HT1Dalpha Receptor; 5-Hydroxytryptamine1D Receptor; Receptor, Serotonin 1D; Receptor, Serotonin 1Dalpha; Serotonin 1D Alpha Receptor; Serotonin 1D Receptors; Serotonin 1Dalpha Receptor; Serotonin 1Dalpha Receptors; 5 HT1D Receptor; 5 Hydroxytryptamine1D Receptor; Receptor, 5-HT1D; Receptor, 5-Hydroxytryptamine1D; Receptors, Serotonin 1D; Serotonin 1D Receptor
Networked: 61 relevant articles (6 outcomes, 9 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Ivanusic, Jason J: 2 articles (05/2011 - 03/2011)
2. Jennings, Ernest A: 2 articles (05/2011 - 03/2011)
3. Kwok, Matthew M K: 2 articles (05/2011 - 03/2011)
4. Ahn, Andrew H: 2 articles (03/2011 - 08/2006)
5. Gianotti, L: 2 articles (06/2003 - 05/2001)
6. Limone, P: 2 articles (06/2003 - 05/2001)
7. Del Rizzo, P: 2 articles (06/2003 - 05/2001)
8. Valfrè, W: 2 articles (06/2003 - 05/2001)
9. Arvat, E: 2 articles (06/2003 - 05/2001)
10. Rainero, I: 2 articles (06/2003 - 05/2001)

Related Diseases

1. Migraine Disorders (Migraine)
2. Cluster Headache (Cluster Headaches)
3. Ganglion Cysts (Ganglion)
4. Headache (Headaches)
5. Bipolar Disorder (Mania)

Related Drugs and Biologics

1. Sumatriptan (Imigran)
2. Serotonin (5 Hydroxytryptamine)
3. Tryptamines (Triptans)
4. Ligands
5. rizatriptan (Maxalt)
6. zolmitriptan (Zomig)
7. Serotonin Receptor Agonists (Serotonin Receptor Agonist)
8. Messenger RNA (mRNA)
9. BRL 15572
10. GR 127935